{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:03:18Z","timestamp":1704326598644},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Absztrakt: <\/jats:title>\n \n Bevezet\u00e9s:<\/jats:italic> A nem okkluz\u00edv mesenterialis ischaemia (NOMI)\n anat\u00f3miai okok n\u00e9lk\u00fcl alakul ki, korai diagnosztiz\u00e1l\u00e1sa neh\u00e9z, ter\u00e1pi\u00e1ja sem\n megoldott. Modellk\u00eds\u00e9rleteinkben a komplement C5a g\u00e1tl\u00e1s\u00e1n kereszt\u00fcl a\n komplementaktiv\u00e1ci\u00f3 szerep\u00e9t vizsg\u00e1ltuk a k\u00f3rfolyamatban.\n Anyagok<\/jats:italic>\u00e9s m\u00f3dszerek:<\/jats:italic> A NOMI r\u00f6vid \u00e9s hossz\u00fa t\u00e1v\u00fa hemodinamikai \u00e9s\n gyullad\u00e1sos k\u00f6vetkezm\u00e9nyeinek jellemz\u00e9s\u00e9hez Sprague\u2013Dawley patk\u00e1nyokban\n (n<\/jats:italic> = 28) 60 perces parci\u00e1lis aortaokkl\u00fazi\u00f3t (PAO; hasi\n aorta, truncus coeliacust\u00f3l proxim\u00e1lisan; arteria femoralis k\u00f6z\u00e9pnyom\u00e1sa: 30\u201340\n Hgmm), m\u00edg vietnami t\u00f6rpesert\u00e9sekben (n<\/jats:italic> = 19) 60 perces\n pericardialis tampon\u00e1dot (art\u00e9ri\u00e1s k\u00f6z\u00e9pnyom\u00e1s: 40\u201350 Hgmm) hoztunk l\u00e9tre. A\n PAO, valamint a tampon\u00e1d 45. perc\u00e9ben komplement C5a-g\u00e1tl\u00f3 kezel\u00e9st alkalmaztunk\n (acetil-peptid-A; 4 mg\/kg iv.<\/jats:italic>). Az \u00e1llatokban monitoroztuk a\n makro- \u00e9s mikrokering\u00e9st, m\u00e9rt\u00fck a leukocytainfiltr\u00e1ci\u00f3t, a gyullad\u00e1sos\n medi\u00e1torok (endothelin, HMGB-1) plazmaszintj\u00e9t. Eredm\u00e9nyek:<\/jats:italic>\n Patk\u00e1nyokban a PAO megsz\u00fcntet\u00e9se ut\u00e1n 24 \u00f3r\u00e1val a C5a g\u00e1tl\u00e1sa cs\u00f6kkentette a\n sziszt\u00e9m\u00e1s gyullad\u00e1sos v\u00e1lasz r\u00e9szek\u00e9nt megemelkedett perct\u00e9rfogatot (203,1 \u00b1 5\n vs. 269,6 \u00b1 8,1 ml\/\u200cmin\/\u200ckg) \u00e9s arteria mesenterica superior (AMS)\n \u00e1raml\u00e1s\u00e1t, fokozta az ileum mucosa mikrokering\u00e9s\u00e9t (833,5 \u00b1 33,8 vs. 441,9 \u00b1\n 22,4 \u03bcm\/s). Az acetil-peptid-A sert\u00e9sekben \u00e1tmenetileg n\u00f6velte az AMS \u00e1raml\u00e1s\u00e1t\n \u00e9s tart\u00f3san az ileummucosa-kapill\u00e1ris\u00e1raml\u00e1st (648,1 \u00b1 45,4 vs. 329,8 \u00b1 12,6\n \u03bcm\/s). A kezelt \u00e1llatokn\u00e1l alacsonyabb gyullad\u00e1sos medi\u00e1torszintet \u00e9s sz\u00f6veti\n leukocytainfiltr\u00e1ci\u00f3t m\u00e9rt\u00fcnk mindk\u00e9t NOMI-modellben.\n K\u00f6vetkeztet\u00e9sek:<\/jats:italic> A komplementaktiv\u00e1ci\u00f3 jelent\u0151s szerepet\n j\u00e1tszik a NOMI alatt bek\u00f6vetkez\u0151 makro- \u00e9s mikrokering\u00e9si zavar kialakul\u00e1s\u00e1ban,\n a C5a g\u00e1tl\u00e1sa a gyullad\u00e1sos folyamat m\u00e9rs\u00e9kl\u00e9se mellett befoly\u00e1solja a NOMI\n hemodinamikai k\u00f6vetkezm\u00e9nyeit is.<\/jats:p>","DOI":"10.1556\/1046.70.2017.3.2","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T15:18:05Z","timestamp":1504711085000},"page":"221-231","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Komplement C5a-antagonista-ter\u00e1pia hat\u00e1sa nem okkl\u00faz\u00edv mesenterialis ischaemia \u00e1llatmodelljeiben"],"prefix":"10.1556","volume":"70","author":[{"given":"Mikl\u00f3s","family":"N\u00f3gr\u00e1dy","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."},{"name":"2 Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetemSzeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Varga","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szil\u00e1rd","family":"Sz\u0171cs","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Kaszaki","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Boros","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"\u00c9rces","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."},{"name":"1 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem6720 Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 6."},{"name":"2 Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetemSzeged"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Magyar Seb\u00e9szet (Hungarian Journal of Surgery)"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/70\/3\/article-p221.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/1046\/70\/3\/article-p221.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/1046\/70\/3\/article-p221.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T16:47:12Z","timestamp":1704300432000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/70\/3\/article-p221.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/1046.70.2017.3.2","relation":{},"ISSN":["0025-0295","1789-4301"],"issn-type":[{"value":"0025-0295","type":"print"},{"value":"1789-4301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}