{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:33:43Z","timestamp":1754487223172},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["IMAS"],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"\n Background<\/jats:title>\n Chronic alcohol ingestion-induced kidney structure and function alterations are very well known, but the precise underlying molecular mediators involved in ethanol-induced kidney abnormalities remain elusive. The aim of this study was to investigate the effect of chronic ethanol exposure on matrix metalloproteinase 2, 9 (MMP), glomerular filtration barrier proteins (nephrin and podocin), as well as vascular endothelial growth factor receptor 1, 2 (VEGFRs) isoforms gene expression in the kidney of rats.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Sixteen male Wistar rats with an initial body weight of 220\u2009\u00b1\u200910\u00a0g were divided into the following two groups: (1) control and (2) ethanol (4.5\u00a0g\/kg BW).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After 6 weeks of treatment, the results revealed a significant increase in isoforms VEGFR1 and VEGFR2 of VEGFR gene expression, significant increases of MMP2 and MMP9 activities, as well as significant decrease of nephrin and podocin gene expressions in the ethanol group, compared with that in the control group.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings indicate that ethanol-induced kidney abnormalities may be in part associated with alteration in expressions of VEGFRs, nephrin, and podocin and in increasing activities of MMP2 and MMP9 as key molecular mediators in the kidney function.<\/jats:p>\n <\/jats:sec>","DOI":"10.1556\/1646.10.2018.23","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:01:06Z","timestamp":1529996466000},"page":"171-177","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Chronic ethanol ingestion induces glomerular filtration barrier proteins genes expression alteration and increases matrix metalloproteinases activity in the kidney of rats"],"prefix":"10.1556","volume":"10","author":[{"given":"Mahrokh","family":"Samadi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physiology, Urmia University of Medical Sciences, Urmia, Iran"},{"name":"Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Shirpoor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology, Urmia University of Medical Sciences, Urmia, Iran"},{"name":"Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Taghizadeh","family":"Afshari","sequence":"additional","affiliation":[{"name":"Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Rasmi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sadeghzadeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Biomed Pharmacother","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.biopha.2016.09.097","article-title":"Ginger extract protects rat\u2019s kidneys against oxidative damage after chronic ethanol administration","volume":"84","author":"Shirpoor\n A","year":"2016","unstructured":"Shirpoor\n A\n \n , \n \n Rezaei\n F\n \n , \n \n Fard\n AA\n \n , \n \n Afshari\n AT\n \n , \n \n Gharalari\n FH\n \n , \n \n Rasmi\n Y\n \n : Ginger extract protects rat\u2019s kidneys against oxidative damage after chronic ethanol administration. 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