{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:27:50Z","timestamp":1792103270440,"version":"4.4.0"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["IMAS"],"published-print":{"date-parts":[[2018,10,26]]},"abstract":"<jats:p>The objective was to develop a stable and non-compliance coated solid\u2013lipid nanoparticles (coated SLN) using polymer (Eudragit L100) and lipoid (glycerol monostearate: soya lecithin) for partial dose reduction of isradipine [ISR; 2.5\u00a0mg by combination of bioenhancing agent (rutin; Ru) in equivalent ratio]. The physicochemical characterizations were performed by FT-IR and DSC of elected model drug (ISR), drug mixer with Ru\/polymer and coated SLN with Ru (ONbp); the resulted distinctive peaks demonstrated that no chemical interaction and incompatibility found between them. The plasma samples of formulation (ONbp) were analyzed by liquid chromatography (HPLC) using UV-spectrometer. Data were integrated and analyzed with the help of a computer-designed program \u201c<jats:italic>Kinetica Software<\/jats:italic>\u201d (Thermo Scientific Kinetica, PK\/PD Analysis, version 5.0, Philadelphia, PA). The pharmacokinetic study showed 3.2- to 4.7-folds enhancement in oral bioavailability of coated SLN of ISR with Ru (ONbp) when compared to a coated formulation of ISR without Ru (ONps) and conventional drug suspension. <jats:italic>In vivo<\/jats:italic> studies were revealed significantly at greater extent in (drug stability and solubility) oral absorption, which has shown potential entrapment efficiency (97.85%\u2009\u00b1\u20091.02%) to improve biological activity against hypertension. Hence, nano-system of ISR against hypertension is achieved with consequent dose reduction with enhanced systemic bioavailability.<\/jats:p>","DOI":"10.1556\/1646.10.2018.45","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T09:12:42Z","timestamp":1540890762000},"page":"236-246","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":16,"title":["Development and evaluation of isradipine via rutin-loaded coated solid\u2013lipid nanoparticles"],"prefix":"10.1556","volume":"10","author":[{"given":"Vikash","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of RIC, I. K. Gujral Punjab Technical University, Kapurthala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"PDM College of Pharmacy, Bahadurgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjoo","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Chandigarh College of Pharmacy, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Adv Drug Deliv Rev","first-page":"S127","article-title":"In-vitro assessment of oral lipid based formulation","volume":"50","author":"Porter\n              CJ","year":"2001","unstructured":"Porter\n              CJ\n            \n            , \n            \n              Charman\n              WN\n            \n          : In-vitro assessment of oral lipid based formulation. 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