{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:11Z","timestamp":1789948871156,"version":"4.0.1"},"reference-count":31,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Interventional Medicine &amp; Applied Science"],"published-print":{"date-parts":[[2016,9,30]]},"abstract":"<jats:sec sec-type=\"background\">\n          <jats:title>Background<\/jats:title>\n          <jats:p>Endothelial cell activation in pre-eclampsia is associated with elevated soluble vascular cell adhesion molecule-1 (sVCAM-1) levels. The objective of the study was to determine whether sVCAM-1 levels in Indonesian women with pre-eclampsia were similar to other ethnic studies and to determine the effects of magnesium sulfate with nifedipine on blood pressure.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"methods\">\n          <jats:title>Methods<\/jats:title>\n          <jats:p>A total of 61 pregnant women were admitted, who had normal pregnancy (<jats:italic>n<\/jats:italic>\u2009=\u200925) and severe pre-eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200936). Blood sampling was performed at admission to the study, 1\u00a0h after placental separation, and 24\u00a0h postpartum. sVCAM-1 and blood pressure levels were determined.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"results\">\n          <jats:title>Results<\/jats:title>\n          <jats:p>The mean ages in normal pregnancy (<jats:italic>n<\/jats:italic>\u2009=\u200925) and in severe pre-eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200936) are 30.0\u2009\u00b1\u20093.4 years and 27.1\u2009\u00b1\u20096.1 years, respectively. Significantly elevated sVCAM-1 was seen in pre-eclampsia. No significant variation in sVCAM-1 levels during the study periods was seen in both groups of cohorts. Magnesium sulfate infusion and nifedipine significantly lowered the blood pressure level.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"conclusion\">\n          <jats:title>Conclusion<\/jats:title>\n          <jats:p>Elevated sVCAM-1 levels were also seen in Indonesian women with severe pre-eclampsia. The placenta may not be the only source of elevated sVCAM-1 and that endothelial dysfunction persists beyond the postpartum period. Magnesium sulfate together with nifedipine significantly lowered blood pressure. The determination of elevated sVCAM-1 in pregnancy as a risk marker for endothelial dysfunction is therefore suggested.<\/jats:p>\n        <\/jats:sec>","DOI":"10.1556\/1646.8.2016.3.4","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T08:35:16Z","timestamp":1475483716000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["Soluble vascular cell adhesion molecule-1 and magnesium sulfate with nifedipine treatment in Indonesian women with severe pre-eclampsia"],"prefix":"10.1556","volume":"8","author":[{"given":"Hotma Partogi","family":"Pasaribu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Hariman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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