{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:02:30Z","timestamp":1704326550097},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[1900,1,1]],"date-time":"1900-01-01T00:00:00Z","timestamp":-2208988800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Interventional Medicine and Applied Science"],"published-print":{"date-parts":[[1900,1,1]]},"abstract":"<jats:sec sec-type=\"introduction\">\n          <jats:title>Introduction<\/jats:title>\n          <jats:p>This study reports a novel strategy for investigating the key factors responsible for the protective effect of remote ischemic preconditioning (RIPC) against renal ischemia-reperfusion (IR) injury, which remains the leading cause of the acute kidney injury that increase the morbidity and mortality in patients with renal impairment.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"methods\">\n          <jats:title>Methods<\/jats:title>\n          <jats:p>The renal blood flow of the right kidneys in kidney remote ischemic preconditioning (KRIPC) group was occluded for 20\u00a0min. After 48\u00a0h, the renal blood flow of the left kidneys of both KRIPC and IPC groups was occluded for 30\u00a0min, and mice were dissected after 7 days of the last surgery. Blood samples were analyzed by an animal blood counter. The levels of creatinine, urea nitrogen, lipid peroxidation, nitric oxide (NO), and high-density lipoproteins (HDLs) were estimated in the plasma of mice. Kidney slices were stained with 2% triphenyltetrazolium chloride (TTC) to estimate the renal infarction.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"results\">\n          <jats:title>Results<\/jats:title>\n          <jats:p>Unlike KRIPC group, data from IPC group revealed a massive reduction in neutrophils count, a significant increase in creatinine, urea nitrogen, and HDLs levels, and an increase in the renal infarction compared with control group.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"conclusions\">\n          <jats:title>Conclusion<\/jats:title>\n          <jats:p>This is the first study demonstrating KRIPC as a novel and applicable model with the goal of defining the accurate protective mechanisms underlying RIPC against IR injury.<\/jats:p>\n        <\/jats:sec>","DOI":"10.1556\/1646.9.2017.1.12","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T07:18:27Z","timestamp":1490599107000},"page":"20-26","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Kidney remote ischemic preconditioning as a novel strategy to explore the accurate protective mechanisms underlying remote ischemic preconditioning"],"prefix":"10.1556","volume":"9","author":[{"given":"Muobarak J.","family":"Tuorkey","sequence":"first","affiliation":[{"name":"Zoology Department, Division of Physiology, Faculty of Science, Damanhour University, Damanhour, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Physiol Res","doi-asserted-by":"publisher","first-page":"55","DOI":"10.33549\/physiolres.933392","article-title":"Remote preconditioning as a novel \u201cconditioning\u201d approach to repair the broken heart: Potential mechanisms and clinical applications","volume":"65","author":"Ravingerova\n              T","year":"2016","unstructured":"Ravingerova\n              T\n            \n            , \n            \n              Farkasova\n              V\n            \n            , \n            \n              Griecsova\n              L\n            \n            , \n            \n              Carnicka\n              S\n            \n            , \n            \n              Murarikova\n              M\n            \n            , \n            \n              Barlaka\n              E\n            \n            , \n            \n              Kolar\n              F\n            \n            , \n            \n              Bartekova\n              M\n            \n            , \n            \n              Lonek\n              L\n            \n            , \n            \n              Slezak\n              J\n            \n            , \n            \n              Lazou\n              A\n            \n          : Remote preconditioning as a novel \u201cconditioning\u201d approach to repair the broken heart: Potential mechanisms and clinical applications. 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