{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:17:46Z","timestamp":1777439866203,"version":"3.51.4"},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The octapeptide NAP is well known for its neuroprotective properties. We here investigated whether NAP treatment could alleviate pro-inflammatory immune responses during experimental subacute ileitis. To address this, mice with a human gut microbiota were perorally infected with one cyst of <jats:italic>Toxoplasma gondii<\/jats:italic> (day 0) and subjected to intraperitoneal synthetic NAP treatment from day 1 until day 8 postinfection (p.i.). Whereas placebo (PLC) control animals displayed subacute ileitis at day 9 p.i., NAP-treated mice exhibited less pronounced pro-inflammatory immune responses as indicated by lower numbers of intestinal mucosal T and B lymphocytes and lower interferon (IFN)-\u03b3 concentrations in mesenteric lymph nodes. The NAP-induced anti-inflammatory effects were not restricted to the intestinal tract but could also be observed in extra-intestinal including systemic compartments, given that pro-inflammatory cytokines were lower in liver, kidney, and lung following NAP as compared to PLC application, whereas at day 9 p.i., colonic and serum interleukin (IL)-10 concentrations were higher in the former as compared to the latter. Remarkably, probiotic commensal bifidobacterial loads were higher in the ileal lumen of NAP as compared to PLC-treated mice with ileitis. Our findings thus further support that NAP might be regarded as future treatment option directed against intestinal inflammation.<\/jats:p>","DOI":"10.1556\/1886.2018.00006","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T16:50:41Z","timestamp":1527007841000},"page":"34-40","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":15,"title":["Anti-inflammatory effects of the octapeptide NAP in human microbiota-associated mice suffering from subacute ileitis"],"prefix":"10.1556","volume":"8","author":[{"given":"Ulrike","family":"Escher","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Institute of Microbiology and Infection Immunology, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliezer","family":"Giladi","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f2 R.","family":"Dunay","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Institute of Microbiology and Infection Immunology, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Illana","family":"Gozes","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Institute of Microbiology and Infection Immunology, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref1","series-title":"J Neurochem","first-page":"1283","article-title":"Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide","volume":"8","author":"Bassan, M","year":"1999","unstructured":"Bassan, M\n            \n              Zamostiano, R\n            \n              Davidson, A\n            \n              Pinhasov, A\n            \n              Giladi, E\n            \n              Perl, O, \n          Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. 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Gut Pathog. 2017;9:4.10.1186\/s13099-017-0154-4"},{"key":"ref16","series-title":"Eur J Microbiol Immunol","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1556\/1886.2017.00002","article-title":"Comprehensive survey of intestinal microbiota changes in offspring of human microbiota-associated mice","volume":"7","author":"von Klitzing, E","year":"2017","unstructured":"von Klitzing, E\n            \n              Oz, F\n            \n              Ekmekciu, I\n            \n              Escher, U\n            \n              Bereswill, S\n            \n              Heimesaat, MM\n          . Comprehensive survey of intestinal microbiota changes in offspring of human microbiota-associated mice. 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