{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:08:51Z","timestamp":1747199331547,"version":"3.40.5"},"reference-count":92,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The physiological colonization resistance exerted by the murine gut microbiota prevents conventional mice from <jats:italic>Campylobacter jejuni<\/jats:italic> infection. In the present study we addressed whether this also held true for <jats:italic>Campylobacter coli<\/jats:italic>. Following peroral application, <jats:italic>C. coli<\/jats:italic> as opposed to <jats:italic>C. jejuni<\/jats:italic> could stably establish within the gastrointestinal tract of conventionally colonized mice until 3 weeks post-challenge. Neither before nor after either <jats:italic>Campylobacter<\/jats:italic> application any changes in the gut microbiota composition could be observed. <jats:italic>C. coli<\/jats:italic>, but not <jats:italic>C. jejuni<\/jats:italic> challenge was associated with pronounced regenerative, but not apoptotic responses in colonic epithelia. At day 21 following <jats:italic>C. coli<\/jats:italic> versus <jats:italic>C. jejuni<\/jats:italic> application mice exhibited higher numbers of adaptive immune cells including T-lymphocytes and regulatory T-cells in the colonic mucosa and lamina propria that were accompanied by higher large intestinal interferon-\u03b3 (IFN-\u03b3) concentrations in the former versus the latter but comparable to naive levels. <jats:italic>Campylobacter<\/jats:italic> application resulted in decreased splenic IFN-\u03b3, tumor necrosis factor-\u03b1 (TNF-\u03b1), and IL-6 concentrations, whereas IL-12p70 secretion was increased in the spleens at day 21 following <jats:italic>C. coli<\/jats:italic> application only. In either <jats:italic>Campylobacter<\/jats:italic> cohort decreased IL-10 concentrations could be measured in splenic and serum samples. In conclusion, the commensal gut microbiota prevents mice from <jats:italic>C. jejuni<\/jats:italic>, but not <jats:italic>C. coli<\/jats:italic> infection.<\/jats:p>","DOI":"10.1556\/1886.2020.00004","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T07:49:12Z","timestamp":1588578552000},"page":"80-90","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":7,"title":["The conundrum of colonization resistance against Campylobacter reloaded: The gut microbota composition in conventional mice does not prevent from Campylobacter coli infection"],"prefix":"10.1556","volume":"10","author":[{"given":"Claudia","family":"Genger","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9 \u2013 University Medicine Berlin, corporate member of Freie Universit\u00e4t Berlin, 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