{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:02:29Z","timestamp":1782316949807,"version":"3.54.5"},"reference-count":41,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Doxycycline-based prevention of bacterial sexually transmitted infections (STIs) has been assessed in various studies and has been recommended by the European AIDS Clinical Society to be proposed to persons with repeated STIs on a case-by-case basis. However, while good preventive effects could be shown for <jats:italic>Chlamydia trachomatis<\/jats:italic> and <jats:italic>Treponema pallidum<\/jats:italic> in Europe, no reliable prevention against doxycycline resistance-affected bacterial causes of STIs like <jats:italic>Neisseria gonorrhoeae<\/jats:italic> and <jats:italic>Mycoplasma genitalium<\/jats:italic> was confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a modelling-approach, we assessed potential beneficial effects even against the latter microorganisms in case of optimized adherence with doxycycline prevention. These effects were modelled for Germany in comparison to traditional prevention schemes like condom-based STI-prevention and testing-as-prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With estimated risk reduction in the ranges of 86% for <jats:italic>N. gonorrhoeae<\/jats:italic> and of 82% for <jats:italic>Mycoplasma genitalium<\/jats:italic>, expectable preventive efficacy similar to alternative preventive approaches could be calculated in case of optimized adherence with doxycycline prevention. In case of repeated risk exposure, the preventive potential of condom-based prevention was decreased compared to both optimized doxycycline prevention and testing-as-prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As suggested by the applied modelling, the preventive effect of optimized doxycycline prevention against bacterial STIs is in a similar range, like other common prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1556\/1886.2023.00059","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T12:40:31Z","timestamp":1706618431000},"page":"50-58","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention"],"prefix":"10.1556","volume":"14","author":[{"given":"Andreas","family":"Hahn","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-9528","authenticated-orcid":true,"given":"Hagen","family":"Frickmann","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany"},{"name":"Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Loderst\u00e4dt","sequence":"additional","affiliation":[{"name":"Institute for Infection Control and Infectious Diseases, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"N Engl J Med","first-page":"2237","article-title":"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection","volume":"373","author":"Molina JM","year":"2015","unstructured":"Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et\u00a0al. 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Management of asymptomatic sexually transmitted infections in Europe: towards a differentiated, evidence-based approach. Lancet Reg Health Eur. 2023;34:100743."},{"key":"B35","series-title":"Hum Vaccin Immunother","first-page":"1058","article-title":"Impact of meningococcal group B OMV vaccines, beyond their brief","volume":"14","author":"Petousis-Harris H","year":"2018","unstructured":"Petousis-Harris H. Impact of meningococcal group B OMV vaccines, beyond their brief. Hum Vaccin Immunother 2018;14:1058\u201363."},{"key":"B36","series-title":"Front Microbiol","article-title":"Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP","volume":"14","author":"Kenyon C","year":"2023","unstructured":"Kenyon C, Gestels Z, Vanbaelen T, Abdellati S, Van Den Bossche D, De Baetselier I, et al. Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP. Front Microbiol. 2023;14:1208014."},{"key":"B37","series-title":"Int J STD AIDS","first-page":"962","article-title":"Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: an in silico analysis","volume":"34","author":"Gestels Z","year":"2023","unstructured":"Gestels Z, Manoharan-Basil SS, Kenyon C. Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: an in silico analysis. Int J STD AIDS. 2023;34:962\u20138."},{"key":"B38","series-title":"Clin Infect Dis","first-page":"837","article-title":"Antimicrobials increase travelers' risk of colonization by extended-spectrum betalactamase-producing Enterobacteriaceae","volume":"60","author":"Kantele A","year":"2015","unstructured":"Kantele A, L\u00e4\u00e4veri T, Mero S, Vilkman K, Pakkanen SH, Ollgren J, et al. 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