{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:21:32Z","timestamp":1792513292867,"version":"4.5.0"},"reference-count":136,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Staphylococcus aureus<\/jats:italic> infections have already presented a substantial public health challenge, encompassing different clinical manifestations, ranging from bacteremia to sepsis and multi-organ failures. Among these infections, methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) is particularly alarming due to its well-documented resistance to multiple classes of antibiotics, contributing significantly to global mortality rates. Consequently, the urgent need for effective treatment options has prompted a growing interest in exploring phage therapy as a potential non-antibiotic treatment against MRSA infections. Phages represent a class of highly specific bacterial viruses known for their ability to infect certain bacterial strains. This review paper explores the clinical potential of phages as a treatment for MRSA infections due to their low toxicity and auto-dosing capabilities. The paper also discusses the synergistic effect of phage-antibiotic combination (PAC) and the promising results from in vitro and animal model studies, which could lead to extensive human clinical trials. However, clinicians need to establish and adhere to\u00a0standard protocols governing phage administration and implementation. Prominent clinical trials are\u00a0needed to develop and advance phage therapy as a non-antibiotic therapy intervention, meeting regulatory guidelines, logistical requirements, and ethical considerations, potentially revolutionizing the treatment of MRSA infections.<\/jats:p>","DOI":"10.1556\/1886.2023.00064","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T08:12:46Z","timestamp":1706861566000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review"],"prefix":"10.1556","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-3580","authenticated-orcid":true,"given":"Jamil Allen G.","family":"Fortaleza","sequence":"first","affiliation":[{"name":"Senior High School Department, NU Fairview Incorporated, Quezon City, 1118, Philippines"},{"name":"National University, Philippines, Sampaloc, Manila, 1008, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0096-9773","authenticated-orcid":true,"given":"Christian Joseph N.","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, De La Salle University, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-4000","authenticated-orcid":true,"given":"Rener","family":"De Jesus","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United\u00a0Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"s2","key":"B1","series-title":"Intern Med J","first-page":"S97","article-title":"Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue","volume":"35","author":"Roberts S","year":"2005","unstructured":"Roberts S, Chambers S. 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