{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:09:06Z","timestamp":1747199346823,"version":"3.40.5"},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Borrelia burgdorferi<\/jats:italic>, the causative agent of Lyme disease, has recently been demonstrated to infect and\u00a0enhance the invasive properties of breast cancer cells, while also influencing the expression of inflammatory chemokines (CXCL8 and CXCL10). This study investigates the presence of <jats:italic>B. burgdorferi<\/jats:italic> in invasive breast cancer tissues using commercially available, FDA-approved breast cancer tissue microarrays consisting of 350 ductal, 32 lobular, and 22 intraductal invasive breast carcinomas, alongside 29 normal breast tissues. Employing fluorescent immunohistochemical staining and high-resolution imaging, the findings revealed that approximately 20% of invasive lobular and ductal carcinomas, followed by 14% of intraductal carcinomas, tested positive for <jats:italic>B. burgdorferi<\/jats:italic>, while all normal breast tissues tested negative. PCR analysis further confirmed the presence of <jats:italic>B. burgdorferi<\/jats:italic> DNA in breast cancer tissues. Moreover, 25% of <jats:italic>B. burgdorferi<\/jats:italic>-positive tissues exhibited expression of both chemokines, CXCL8 and CXCL10, which was not observed in <jats:italic>B. burgdorferi<\/jats:italic>-negative tissues. Analysis of\u00a0available patient data, including age, indicated a correlation between older patients and <jats:italic>B. burgdorferi<\/jats:italic>-positive tissues. This study validates the presence of <jats:italic>B. burgdorferi<\/jats:italic> in invasive breast cancer tissues and\u00a0highlights the involvement of key CXCL family members associated with inflammatory processes.<\/jats:p>","DOI":"10.1556\/1886.2024.00021","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T09:44:01Z","timestamp":1709804641000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Evidence for the presence of Borrelia burgdorferi in invasive breast cancer tissues"],"prefix":"10.1556","volume":"14","author":[{"given":"Niraj Jatin","family":"Patel","sequence":"first","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahaja","family":"Thippani","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Jathan","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Gaur","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janhavi Y.","family":"Sawant","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"Pandya","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-1455","authenticated-orcid":true,"given":"Eva","family":"Sapi","sequence":"additional","affiliation":[{"name":"Lyme Disease Research Group, Department of Biology and Environmental Science, University of New Haven, 300 Boston Post Road, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"article-title":"Cancer facts & figures","author":"American Cancer Society","key":"B1","unstructured":"American Cancer Society. 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Helicobacter pylori associated factors in the development of gastric cancer with special reference to the early-onset subtype. Oncotarget. 2018;9(57):31146\u201331162. https:\/\/doi.org\/10.18632\/oncotarget.25757."},{"key":"B4","series-title":"Clin Exp Gastroenterol","first-page":"151","article-title":"The bacterial microbiota of gastrointestinal cancers: role in cancer pathogenesis and therapeutic perspectives","volume":"13","author":"Elsalem L","year":"2020","unstructured":"Elsalem L, Jum\u2019ah AA, Alfaqih MA, Aloudat O. The bacterial microbiota of gastrointestinal cancers: role in cancer pathogenesis and therapeutic perspectives. Clin Exp Gastroenterol. 2020;13:151\u2013185. https:\/\/doi.org\/10.2147\/CEG.S243337."},{"issue":"1","key":"B5","series-title":"Infect Agent Cancer","first-page":"11","article-title":"Bacteria and tumours: causative agents or\u00a0opportunistic inhabitants?","volume":"8","author":"Cummins J","year":"2013","unstructured":"Cummins J, Tangney M. Bacteria and tumours: causative agents or\u00a0opportunistic inhabitants? Infect Agent Cancer. 2013;8(1):11. https:\/\/doi.org\/10.1186\/1750-9378-8-11."},{"issue":"4","key":"B6","series-title":"Int J Mol Sci","article-title":"Bacterial infections and cancer: exploring this association and its implications for cancer patients","volume":"24","author":"Yusuf K","year":"2023","unstructured":"Yusuf K, Sampath V, Umar S. Bacterial infections and cancer: exploring this association and its implications for cancer patients Int J Mol Sci. 2023;24(4):3110\u20133110. https:\/\/doi.org\/10.3390\/ijms24043110."},{"issue":"3","key":"B7","series-title":"Appl Environ Microbiol","first-page":"146","article-title":"The microbiota of breast tissue and its association with breast cancer","volume":"6","author":"Urbaniak C","year":"2016","unstructured":"Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G. The microbiota of breast tissue and its association with breast cancer. 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Cytokines and the pathogenesis of neuroborreliosis: Borrelia burgdorferi induces glioma cells to secrete interleukin-6. J Infect Dis. 1991;164(3):568\u2013574. https:\/\/doi.org\/10.1093\/infdis\/164.3.568."},{"issue":"7","key":"B40","series-title":"PLoS One","article-title":"Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional cerebrospinal fluid neuroinflammatory biomarkers","volume":"14","author":"Liba Z","year":"2019","unstructured":"Liba Z, Nohejlova H, Capek V, Krsek P, Sediva A, Kayserova J. Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional cerebrospinal fluid neuroinflammatory biomarkers. 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CXCL10 alters the tumour immune microenvironment and disease progression in a syngeneic murine model of high-grade serous ovarian cancer. 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