{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:21Z","timestamp":1789556841419,"version":"build-2803163510"},"reference-count":23,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Actinomycetoma, a neglected tropical disease affecting the skin and soft tissues, is primarily caused by filamentous bacteria including <jats:italic>Nocardia<\/jats:italic> species. Here, we report a healthy 56-year-old man who has a one-year history of nodular lesions with seropurulent discharge on his right knee. Despite negative initial tissue culture, the sulfur granules that were partially acid-fast and Gram-positive branching filamentous rods were revealed in the tissue section. Repeated investigation identified the rare pathogen <jats:italic>Nocardia wallacei,<\/jats:italic> using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S ribosomal ribonucleic acid (rRNA) gene sequencing. The patient was successfully treated with a six-month course of trimethoprim-sulfamethoxazole.<\/jats:p><jats:p>This report describes a rare case of actinomycetoma due to <jats:italic>N. wallacei,<\/jats:italic> highlighting the challenges in diagnosis and the importance of accurate pathogen identification for the successful management of infection. The current literature regarding the causative agent will also be discussed.<\/jats:p>","DOI":"10.1556\/1886.2024.00110","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:05:37Z","timestamp":1732021537000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Nocardia wallacei: A rare cause of\u00a0actinomycetoma in an immunocompetent\u00a0patient"],"prefix":"10.1556","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-9685","authenticated-orcid":true,"given":"Panjit","family":"Chieosilapatham","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-1688","authenticated-orcid":true,"given":"Kwanjit","family":"Duangsonk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-0148","authenticated-orcid":true,"given":"Issara","family":"Kaweewan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-675X","authenticated-orcid":true,"given":"Siripong","family":"Tongjai","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-1903","authenticated-orcid":true,"given":"Thanat","family":"Kanthawang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"10","key":"B1","series-title":"J Eur Acad Dermatol Venereol","first-page":"1873","article-title":"Eumycetoma and actinomycetoma-an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy","volume":"29","author":"Nenoff P","year":"2015","unstructured":"Nenoff P, van de Sande WW, Fahal AH, Reinel D, Schofer H. 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