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Here, we used differential effects\u00a0of distinct antibiotics on gut microbiota composition to identify microbial groups associated with CR against <jats:italic>C. jejuni<\/jats:italic>. Therefore, specific pathogen-free (SPF) mice were subjected to ampicillin plus sulbactam (A\/S), ciprofloxacin (CIP), or vancomycin (VAN) via the drinking water for 28 days or left untreated before peroral <jats:italic>C. jejuni<\/jats:italic> challenge. Cultural analyses revealed that CR displayed by untreated mice was abrogated by A\/S treatment, but only reduced in mice treated with CIP or VAN. Notably, differential analysis of antibiotic-induced microbiota changes and <jats:italic>C. jejuni<\/jats:italic> colonization dynamics identified lactobacilli and <jats:italic>Clostridium leptum<\/jats:italic> as key microbial groups that were associated with CR. Notably, the complete eradication of intestinal bacteria in A\/S treated mice supported high intestinal <jats:italic>C.\u00a0jejuni<\/jats:italic> colonization levels which triggered apoptosis and inflammatory responses accompanied by enhanced expression of matrix-degrading gelatinases in the colon. In conclusion, A\/S treated mice represent a valuable infection model for the study of campylobacteriosis and the treatment of mice with\u00a0specific antibiotics support the investigation of molecular mechanisms involved in CR against enteropathogens.<\/jats:p>","DOI":"10.1556\/1886.2024.00140","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T12:55:08Z","timestamp":1739192108000},"page":"42-56","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Differential antibiosis predisposes mice to Campylobacter jejuni infection: Deeper insights into the impact of the gut microbiota composition in colonization resistance"],"prefix":"10.1556","volume":"15","author":[{"given":"Nizar W.","family":"Shayya","sequence":"first","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Stingl","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Campylobacter, Department of Biological Safety, German Federal Institute for Risk Assessment (BfR), 12277 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":true,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"issue":"12","key":"B1","series-title":"Microbes Infect","first-page":"1023","article-title":"Pathophysiology of Campylobacter jejuni infections of humans","volume":"1","author":"Wassenaar TM","year":"1999","unstructured":"Wassenaar TM, Blaser MJ. 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