{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T08:40:06Z","timestamp":1751272806400,"version":"3.41.0"},"reference-count":71,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ESTHER Alliance for Global Health Partnerships"},{"name":"German Federal Ministry of Education and Research","award":["01KA1102"],"award-info":[{"award-number":["01KA1102"]}]},{"name":"German Ministry of Defense","award":["36K2-S-45 1922"],"award-info":[{"award-number":["36K2-S-45 1922"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["EuJMI"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interactions of helminth infections and human immunodeficiency virus (HIV) remain incompletely understood. This study aimed to assess the clinical, epidemiological, and immunological characteristics of co-infections involving HIV and selected nematode, trematode and cestode species commonly detected in stool samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was conducted among people-living-with-HIV (PLWH) with and without anti-retroviral therapy and HIV-negative controls at a tertiary hospital in Kumasi, Ghana. Stool samples were analyzed by real-time PCR for the presence of <jats:italic>Strongyloides stercoralis<\/jats:italic>, <jats:italic>Schistosoma<\/jats:italic> spp. as well as <jats:italic>Taenia<\/jats:italic> spp. Diagnostic findings were compared with clinical, demographic, socioeconomic and immunological data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low prevalences of helminth infections were observed across the study population, ranging from 1.9% for <jats:italic>S. stercoralis<\/jats:italic> to 2.8% for <jats:italic>Schistosoma<\/jats:italic> spp. Only weak and infrequent associations were found between helminth infections and HIV status or immunosuppression. Identified risk factors included male sex, younger age, shorter duration since HIV diagnosis, and poor food hygiene in the case of taeniasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this Ghanaian population, co-infections of HIV and helminths were infrequent and showed limited immunological associations. These findings suggest that helminth detection in PLWH is more likely to reflect local endemicity than HIV-related immunosuppression.<\/jats:p><\/jats:sec>","DOI":"10.1556\/1886.2025.00031","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T14:53:24Z","timestamp":1750863204000},"page":"113-124","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological, clinical and immunological features of Schistosoma spp., Stronglyoides stercoralis and Taenia spp. infections in Ghanaian HIV patients"],"prefix":"10.1556","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-9528","authenticated-orcid":true,"given":"Hagen","family":"Frickmann","sequence":"first","affiliation":[{"name":"Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany"},{"name":"Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred Stephen","family":"Sarfo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana"},{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty Roberta","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana"},{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Dompreh","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Kofi","family":"Agyei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana"},{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadrack Osei","family":"Asibey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Boateng","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Osei","family":"Kuffour","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, The Rockefeller University, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Di Cristanziano","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Loderst\u00e4dt","sequence":"additional","affiliation":[{"name":"Department of Hospital Hygiene & Infectious Diseases, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tafese Beyene","family":"Tufa","sequence":"additional","affiliation":[{"name":"Asella Referral and Teaching Hospital, College of Health Sciences, Arsi University, Asella, Ethiopia"},{"name":"Hirsch Institute of Tropical Medicine (HITM), Heinrich-Heine University, Asella, Ethiopia"},{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Feldt","sequence":"additional","affiliation":[{"name":"Hirsch Institute of Tropical Medicine (HITM), Heinrich-Heine University, Asella, Ethiopia"},{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten Alexandra","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany"},{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Plos Pathog","article-title":"Immune regulation during helminth infections","volume":"9","author":"Girgis NM","year":"2013","unstructured":"Girgis NM, Gundra UM, Loke P. Immune regulation during helminth infections. Plos Pathog. 2013;9:e1003250."},{"key":"B2","series-title":"Sci Rep","article-title":"Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis","volume":"13","author":"Akanksha K","year":"2023","unstructured":"Akanksha K, Kumari A, Dutta O, Prasanth A, Deeba F, Salam N. Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis. 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