{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:06:22Z","timestamp":1790258782270,"version":"4.1.0"},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["EUJMI"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ulcerative colitis is an inflammatory bowel disease of multi-factorial etiology and responsible for considerable health and socioeconomic burdens given high global prevalence rates. Since current therapy options are associated with various side effects, alternative or adjunct therapy options are utmost wanted. Ferulic acid (FA) is a phenolic compound found in various plants and has attracted scientific interests due to its anti-oxidant properties and recently been hyped as a longevity compound. This systematic review summarizes current evidence for anti-colitogenic effects of FA. Results of the included studies revealed that FA, its derivatives, and synthesized FA-containing nanoparticles i.) alleviated experimental colitis; ii.)\u00a0dampened pro-inflammatory immune responses; iii.) tightened the gut epithelial barrier; and iv.)\u00a0reshaped the gut microbiota composition from a dysbiotic to a well-balanced \u201chealthy\u201d state characterized by high species diversity and dominance of probiotic bacterial taxa. Remarkably, in some studies, the observed anti-colitogenic effects of FA were even more pronounced compared to those exerted by treatment with established medications. In conclusion, FA constitutes a promising alternative or adjunct option in the treatment of ulcerative colitis.<\/jats:p>","DOI":"10.1556\/1886.2026.00034","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:48:35Z","timestamp":1790257715000},"page":"206-216","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Ferulic acid \u2013 A promising candidate molecule for the treatment of colitis"],"prefix":"10.1556","volume":"16","author":[{"given":"Marthe J.","family":"Mende","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":true,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"J Inflamm Res","first-page":"113","article-title":"Inflammatory bowel disease: clinical aspects and treatments","volume":"7","author":"Fakhoury M","year":"2014","unstructured":"Fakhoury M, Negrulj R, Mooranian A, Al-Salami H. Inflammatory bowel disease: clinical aspects and treatments. J Inflamm Res. 2014;7:113\u201320."},{"issue":"10114","key":"B2","series-title":"Lancet","first-page":"2769","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng SC","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et\u00a0al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769\u201378."},{"issue":"5","key":"B3","series-title":"Lancet Gastroenterol Hepatol","first-page":"458","article-title":"The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission","volume":"8","author":"Burisch J","year":"2023","unstructured":"Burisch J, Zhao M, Odes S, De Cruz P, Vermeire S, Bernstein CN, et\u00a0al. The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2023;8(5):458\u201392."},{"issue":"3","key":"B4","series-title":"Gastroenterology","first-page":"647","article-title":"Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses","volume":"157","author":"Piovani D","year":"2019","unstructured":"Piovani D, Danese S, Peyrin-Biroulet L, Nikolopoulos GK, Lytras T, Bonovas S. Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses. Gastroenterology. 2019;157(3):647\u201359 e4."},{"issue":"7422","key":"B5","series-title":"Nature","first-page":"119","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins L","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et\u00a0al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491(7422):119\u201324."},{"issue":"10401","key":"B6","series-title":"Lancet","first-page":"571","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre C","year":"2023","unstructured":"Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis. Lancet. 2023;402(10401):571\u201384."},{"issue":"4","key":"B7","series-title":"Inflamm Bowel Dis","first-page":"639","article-title":"Excessive apoptosis in ulcerative colitis: crosstalk between apoptosis, ROS, ER stress, and intestinal homeostasis","volume":"28","author":"Wan Y","year":"2022","unstructured":"Wan Y, Yang L, Jiang S, Qian D, Duan J. Excessive apoptosis in ulcerative colitis: crosstalk between apoptosis, ROS, ER stress, and intestinal homeostasis. 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Available from: https:\/\/www.nice.org.uk\/guidance\/ng130."},{"key":"B10","series-title":"Deutsche Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)","article-title":"Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 7.0) AWMF online","author":"Blumenstein I","year":"2025","unstructured":"Blumenstein I, Schnoy E, Atreya R, Bettenworth D, de Laffolie J, Kaltz B, et\u00a0al. Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 7.0) AWMF online: Deutsche Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). 2025. Available from: https:\/\/register.awmf.org\/assets\/guidelines\/021-009l_S3_Colitis-ulcerosa_2025-11.pdf."},{"key":"B11","series-title":"ARS Medici Dossier","first-page":"32","article-title":"M. Patienten unter IBD-Therapie - diese Nebenwirkungen sollten Sie kennen","volume":"112","author":"Vavricka SH","year":"2022","unstructured":"Vavricka SH, M. Patienten unter IBD-Therapie - diese Nebenwirkungen sollten Sie kennen. ARS Medici Dossier. 2022;112:32\u20134."},{"issue":"6","key":"B12","series-title":"J Ind Microbiol","first-page":"457","article-title":"Review: biocatalytic transformations of ferulic acid: an abundant aromatic natural product","volume":"15","author":"Rosazza JP","year":"1995","unstructured":"Rosazza JP, Huang Z, Dostal L, Volm T, Rousseau B. Review: biocatalytic transformations of ferulic acid: an abundant aromatic natural product. J Ind Microbiol. 1995;15(6):457\u201371."},{"key":"B13","series-title":"Life Sci","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li D","year":"2021","unstructured":"Li D, Rui YX, Guo SD, Luan F, Liu R, Zeng N. Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives. Life Sci. 2021;284:119921."},{"issue":"4","key":"B14","series-title":"Food Chem","first-page":"691","article-title":"Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review","volume":"109","author":"Zhao Z","year":"2008","unstructured":"Zhao Z, Moghadasian MH. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chem. 2008;109(4):691\u2013702."},{"issue":"6","key":"B15","series-title":"Pharmaceuticals (Basel)","first-page":"912","article-title":"Ferulic acid as an anti-inflammatory agent: insights into molecular mechanisms, pharmacokinetics and applications","volume":"18","author":"Liu J","year":"2025","unstructured":"Liu J, Guan Y, Yang L, Fang H, Sun H, Sun Y, et\u00a0al. Ferulic acid as an anti-inflammatory agent: insights into molecular mechanisms, pharmacokinetics and applications. Pharmaceuticals (Basel). 2025;18(6):912."},{"issue":"6","key":"B16","series-title":"Skin Pharmacol Physiol","first-page":"332","article-title":"Antioxidant properties of ferulic acid and its possible application","volume":"31","author":"Zdunska K","year":"2018","unstructured":"Zdunska K, Dana A, Kolodziejczak A, Rotsztejn H. Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol. 2018;31(6):332\u20136."},{"issue":"11","key":"B17","series-title":"J Nutr","first-page":"3083","article-title":"Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver","volume":"134","author":"Zhao Z","year":"2004","unstructured":"Zhao Z, Egashira Y, Sanada H. Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver. J Nutr. 2004;134(11):3083\u20138."},{"key":"B18","series-title":"Biotechnol Rep (Amst)","first-page":"86","article-title":"Potential applications of ferulic acid from natural sources","volume":"4","author":"Kumar N","year":"2014","unstructured":"Kumar N, Pruthi V. Potential applications of ferulic acid from natural sources. Biotechnol Rep (Amst). 2014;4:86\u201393."},{"issue":"2","key":"B19","series-title":"Pharmaceutics","first-page":"145","article-title":"Phenolic compounds impact on rheumatoid arthritis, inflammatory bowel disease and microbiota modulation","volume":"13","author":"Direito R","year":"2021","unstructured":"Direito R, Rocha J, Sepodes B, Eduardo-Figueira M. Phenolic compounds impact on rheumatoid arthritis, inflammatory bowel disease and microbiota modulation. 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BMJ. 2021;372:n71."},{"issue":"18","key":"B22","series-title":"Animals (Basel)","first-page":"2698","article-title":"Ferulic acid alleviates intestinal inflammatory damage in mice, associated with ameliorating intestinal barrier damage and Gut Microbiota","volume":"15","author":"Huang H","year":"2025","unstructured":"Huang H, Li J, Zuo J, Qiu Y, Li B, Hu R, et\u00a0al. Ferulic acid alleviates intestinal inflammatory damage in mice, associated with ameliorating intestinal barrier damage and Gut Microbiota. Animals (Basel). 2025;15(18):2698."},{"issue":"2","key":"B23","series-title":"J Biochem Mol Toxicol","article-title":"Evaluation of anti-inflammatory and antioxidant effects of ferulic acid and quinic acid on acetic acid-induced ulcerative colitis in rats","volume":"39","author":"Ekhtiar M","year":"2025","unstructured":"Ekhtiar M, Ghasemi-Dehnoo M, Azadegan-Dehkordi F, Bagheri N. Evaluation of anti-inflammatory and antioxidant effects of ferulic acid and quinic acid on acetic acid-induced ulcerative colitis in rats. J Biochem Mol Toxicol. 2025;39(2):e70169."},{"issue":"5","key":"B24","series-title":"Inflammopharmacology","first-page":"2587","article-title":"Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-\u03baB and NF-\u03baB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue","volume":"31","author":"Ghasemi-Dehnoo M","year":"2023","unstructured":"Ghasemi-Dehnoo M, Amini-Khoei H, Lorigooini Z, AnjomShoa M, Rafieian-Kopaei M. Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-\u03baB and NF-\u03baB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue. Inflammopharmacology. 2023;31(5):2587\u201397."},{"issue":"10","key":"B25","series-title":"Cell Death Dis","first-page":"656","article-title":"Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation","volume":"14","author":"Han D","year":"2023","unstructured":"Han D, Wu Y, Lu D, Pang J, Hu J, Zhang X, et\u00a0al. Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation. Cell Death Dis. 2023;14(10):656."},{"issue":"4","key":"B26","series-title":"Molecules (Basel, Switzerland)","first-page":"1720","article-title":"Effects of dietary ferulic acid on intestinal health and ileal microbiota of tianfu broilers challenged with lipopolysaccharide","volume":"28","author":"Tang Z","year":"2023","unstructured":"Tang Z, Shu G, Du H, Zheng Y, Fu H, Zhang W, et\u00a0al. Effects of dietary ferulic acid on intestinal health and ileal microbiota of tianfu broilers challenged with lipopolysaccharide. Molecules (Basel, Switzerland). 2023;28(4):1720."},{"issue":"2","key":"B27","series-title":"Cell Biol Int","first-page":"417","article-title":"Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP\/NLRP3 pathway in rats","volume":"47","author":"Yu S","year":"2023","unstructured":"Yu S, Qian H, Zhang D, Jiang Z. Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP\/NLRP3 pathway in rats. Cell Biol Int. 2023;47(2):417\u201327."},{"issue":"12","key":"B28","series-title":"Antioxidants (Basel)","first-page":"2406","article-title":"The alleviation of Dextran Sulfate Sodium (DSS)-Induced colitis correlate with the logP values of food-derived Electrophilic compounds","volume":"11","author":"Cheng XR","year":"2022","unstructured":"Cheng XR, Yu BT, Song J, Ma JH, Chen YY, Zhang CX, et\u00a0al. The alleviation of Dextran Sulfate Sodium (DSS)-Induced colitis correlate with the logP values of food-derived Electrophilic compounds. Antioxidants (Basel). 2022;11(12):2406."},{"issue":"8","key":"B29","series-title":"Antioxidants (Basel)","first-page":"1448","article-title":"Ferulic acid as a protective antioxidant of human intestinal epithelial cells","volume":"11","author":"Hwang HJ","year":"2022","unstructured":"Hwang HJ, Lee SR, Yoon JG, Moon HR, Zhang J, Park E, et\u00a0al. Ferulic acid as a protective antioxidant of human intestinal epithelial cells. Antioxidants (Basel). 2022;11(8):1448."},{"key":"B30","series-title":"EXCLI J","first-page":"482","article-title":"Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats","volume":"15","author":"Sadar SS","year":"2016","unstructured":"Sadar SS, Vyawahare NS, Bodhankar SL. Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats. EXCLI J. 2016;15:482\u201399."},{"key":"B31","series-title":"Front Microbiol","article-title":"Ferulic acid and N-Feruloylserotonin ameliorate LPS-induced intestinal inflammation via modulation of gut microbiota, metabolome, and transcriptome","volume":"16","author":"Hu X","year":"2025","unstructured":"Hu X, Han X, Liu G, Guan G, Xia C. Ferulic acid and N-Feruloylserotonin ameliorate LPS-induced intestinal inflammation via modulation of gut microbiota, metabolome, and transcriptome. Front Microbiol. 2025;16:1597774."},{"issue":"4","key":"B32","series-title":"Toxics","first-page":"268","article-title":"Ferulic acid derivatives ameliorate intestine barrier destruction by alleviating inflammatory responses in Dextran Sulfate sodium-induced inflammatory bowel disease","volume":"12","author":"Kim YY","year":"2024","unstructured":"Kim YY, Hur G, Jang HJ, Jeong S, Lee SW, Lee SJ, et\u00a0al. Ferulic acid derivatives ameliorate intestine barrier destruction by alleviating inflammatory responses in Dextran Sulfate sodium-induced inflammatory bowel disease. Toxics. 2024;12(4):268."},{"issue":"49","key":"B33","series-title":"J Agric Food Chem","first-page":"10730","article-title":"Rutinosylated ferulic acid attenuates food allergic response and colitis by upregulating regulatory T cells in mouse models","volume":"65","author":"Katayama S","year":"2017","unstructured":"Katayama S, Ohno F, Mitani T, Akiyama H, Nakamura S. Rutinosylated ferulic acid attenuates food allergic response and colitis by upregulating regulatory T cells in mouse models. J Agric Food Chem. 2017;65(49):10730\u20137."},{"issue":"4","key":"B34","series-title":"Br J Pharmacol","first-page":"812","article-title":"Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice","volume":"154","author":"Islam MS","year":"2008","unstructured":"Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, et\u00a0al. Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. Br J Pharmacol. 2008;154(4):812\u201324."},{"issue":"11","key":"B35","series-title":"World J Gastroenterol","first-page":"2533","article-title":"Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats","volume":"9","author":"Dong WG","year":"2003","unstructured":"Dong WG, Liu SP, Yu BP, Wu DF, Luo HS, Yu JP. Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats. World J Gastroenterol. 2003;9(11):2533\u20138."},{"issue":"1","key":"B36","series-title":"ACS Nano","first-page":"811","article-title":"Synthetic lignin-derived therapeutic nano reagent as intestinal pH-Sensitive drug carriers capable of bypassing the gastric acid environment for colitis treatment","volume":"17","author":"Zhao C","year":"2023","unstructured":"Zhao C, Yang J, Chen M, Chen W, Yang X, Ye H, et\u00a0al. Synthetic lignin-derived therapeutic nano reagent as intestinal pH-Sensitive drug carriers capable of bypassing the gastric acid environment for colitis treatment. ACS Nano. 2023;17(1):811\u201324."},{"issue":"10","key":"B37","series-title":"Pharmaceutics","first-page":"1263","article-title":"Folate-functionalized ROS-scavenging covalent organic framework for oral targeted delivery of ferulic acid in ulcerative colitis","volume":"17","author":"Xue J","year":"2025","unstructured":"Xue J, Qiao Z, Huang S, Bello MG, Chen L. Folate-functionalized ROS-scavenging covalent organic framework for oral targeted delivery of ferulic acid in ulcerative colitis. Pharmaceutics. 2025;17(10):1263."},{"issue":"Pt 1","key":"B38","series-title":"Int J Biol Macromol","article-title":"Chitosan-tripolyphosphate\/Eudragit(R) S100 nanoparticles containing quinic acid and ferulic acid ameliorate ulcerative colitis in rats via modulating Th17 cells and pro-inflammatory cytokines","volume":"330","author":"Badihi M","year":"2025","unstructured":"Badihi M, Mirzaei Y, Azadegan-Dehkordi F, Taheri F, Khosravian-Dehkordi P, Bagheri N. Chitosan-tripolyphosphate\/Eudragit(R) S100 nanoparticles containing quinic acid and ferulic acid ameliorate ulcerative colitis in rats via modulating Th17 cells and pro-inflammatory cytokines. Int J Biol Macromol. 2025;330(Pt 1):147872."},{"key":"B39","series-title":"Toxicol Appl Pharmacol","article-title":"Pectin-loaded ferulic acid nanoparticles: a potential therapeutic strategy for ulcerative colitis via modulation of the cGAS-STING pathway","volume":"499","author":"Xiao J","year":"2025","unstructured":"Xiao J, Zhou S, Fei F, Long L, Guo C. Pectin-loaded ferulic acid nanoparticles: a potential therapeutic strategy for ulcerative colitis via modulation of the cGAS-STING pathway. Toxicol Appl Pharmacol. 2025;499:117317."},{"issue":"13","key":"B40","series-title":"Foods","first-page":"2345","article-title":"Protective effects of Zein\/Ferulic acid (FA)-Pectin (PEC)\/Chitosan (CS) nanocomplexes on DSS-Induced ulcerative colitis in mice","volume":"14","author":"Guo Y","year":"2025","unstructured":"Guo Y, Yu X, He R, Pei J, Chen H, Chen W. Protective effects of Zein\/Ferulic acid (FA)-Pectin (PEC)\/Chitosan (CS) nanocomplexes on DSS-Induced ulcerative colitis in mice. Foods. 2025;14(13):2345."},{"key":"B41","series-title":"Carbohydr Polym","article-title":"Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H(2)S\/ROS in managing inflammatory bowel disease","volume":"361","author":"Zou J","year":"2025","unstructured":"Zou J, Ding W, Chen Y, Pan X, Fu X, Zheng S, et\u00a0al. Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H(2)S\/ROS in managing inflammatory bowel disease. Carbohydr Polym. 2025;361:123501."},{"key":"B42","series-title":"Carbohydr Polym","article-title":"Versatile inulin\/trans-ferulic acid\/silk sericin nanoparticles-nourished probiotic complex with prolonged intestinal retention for synergistic therapy of inflammatory bowel disease","volume":"350","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Zhang X, Lv L, Gao S, Li X, Wang R, et\u00a0al. Versatile inulin\/trans-ferulic acid\/silk sericin nanoparticles-nourished probiotic complex with prolonged intestinal retention for synergistic therapy of inflammatory bowel disease. Carbohydr Polym. 2025;350:123063."},{"issue":"5","key":"B43","series-title":"Phytother Res","first-page":"2291","article-title":"Ferulic acid alleviates Traumatic brain injury and gastrointestinal disorders by promoting ghrelin to regulate the microbiota-brain-gut axis inflammation and pyroptosis","volume":"39","author":"Cai Y","year":"2025","unstructured":"Cai Y, Zhang X, Zhang Q, Zhou L, Huang Y, Qian H, et\u00a0al. Ferulic acid alleviates Traumatic brain injury and gastrointestinal disorders by promoting ghrelin to regulate the microbiota-brain-gut axis inflammation and pyroptosis. Phytother Res. 2025;39(5):2291\u2013311."},{"issue":"7","key":"B44","series-title":"Eur J Nutr","first-page":"3767","article-title":"Ferulic acid improves intestinal barrier function through altering gut microbiota composition in high-fat diet-induced mice","volume":"61","author":"Tian B","year":"2022","unstructured":"Tian B, Geng Y, Wang P, Cai M, Neng J, Hu J, et\u00a0al. Ferulic acid improves intestinal barrier function through altering gut microbiota composition in high-fat diet-induced mice. Eur J Nutr. 2022;61(7):3767\u201383."},{"issue":"2","key":"B45","series-title":"Tohoku J Exp Med","first-page":"149","article-title":"Ferulic acid alleviates hepatic lipid accumulation and inflammation by improving proximal and distal intestinal barriers in NAFLD mice","volume":"260","author":"Fu J","year":"2023","unstructured":"Fu J, Yang J, He L, Yang C, He J, Hua Y, et\u00a0al. Ferulic acid alleviates hepatic lipid accumulation and inflammation by improving proximal and distal intestinal barriers in NAFLD mice. Tohoku J Exp Med. 2023;260(2):149\u201363."},{"issue":"9","key":"B46","series-title":"Nutrients","first-page":"3152","article-title":"Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells","volume":"13","author":"Serreli G","year":"2021","unstructured":"Serreli G, Naitza MR, Zodio S, Leoni VP, Spada M, Melis MP, et\u00a0al. Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells. 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