{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:07:22Z","timestamp":1790258842771,"version":"4.1.0"},"reference-count":76,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["EUJMI"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sepsis is a multi-system physiological syndrome defined as a dysregulated host response to infection. Despite recent advances clinicians continue to depend on clinically or physiologically defined syndromes as poor classifiers and therefore fail to accurately predict outcome or responses to treatment. Recent studies suggest that advances in screening, diagnosis, prognosis, and treatment of sepsis can be used to tailor immunomodulatory therapies. In the present narrative review, we critically analyze important academic literature published between January 2025 and June 2026 with a focus on epidemiology, screening, diagnosis, prognosis and personalized management. We believe that sepsis care will soon be defined by the convergence of rapid diagnostics, multi-omics profiling, and artificial intelligence, enabling a shift from generalized treatment approaches toward truly personalized, dynamic patient management. While the scientific and technological foundation for this transformation is emerging rapidly, clinical validation using innovative (adaptive) clinical trial design is required. Successful\u00a0implementation within routine care will require multidisciplinary collaboration, robust infrastructure, clinician and patient engagement, and healthcare systems capable of integrating innovation into practice. The coming years may see a paradigm shift in sepsis management comparable to advances observed in personalized management of malignancies.<\/jats:p>","DOI":"10.1556\/1886.2026.00039","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:56:56Z","timestamp":1785412616000},"page":"155-172","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Recent advances in screening, diagnosis, prognosis and personalized treatment of sepsis"],"prefix":"10.1556","volume":"16","author":[{"given":"Natalie N.","family":"Whitfield Jones","sequence":"first","affiliation":[{"name":"Medical and Scientific Affairs, Deepull, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Clements","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailee","family":"Rasania","sequence":"additional","affiliation":[{"name":"Lumanity, Morristown, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Brenner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr An\u00e4sthesiologie und Intensivmedizin, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-5509","authenticated-orcid":true,"given":"Oliver","family":"Liesenfeld","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Mikrobiologie und Infektionsimmunologie, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"10535","key":"B1","series-title":"The Lancet","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(25)02422-5","article-title":"Sepsis","volume":"407","author":"Singer M","year":"2026 Mar","unstructured":"Singer M, Angus DC, Annane D, Bauer M, Kalil AC, Klompas M, et\u00a0al. 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Die Anaesthesiologie. 2026 May 19;75(5):333\u201343. 10.1007\/s00101-026-01663-5https:\/\/doi.org\/10.1007\/s00101-026-01663-5"},{"issue":"12","key":"B3","series-title":"Lancet Glob Health","doi-asserted-by":"publisher","first-page":"e2013","DOI":"10.1016\/S2214-109X(25)00356-0","article-title":"Global, regional, and national sepsis incidence\u00a0and mortality, 1990\u20132021: a systematic analysis","volume":"13","author":"Gray AP","year":"2025 Dec","unstructured":"Gray AP, Chung E, Hsu RL, Araki DT, Gershberg Hayoon A, Davis Weaver N, et\u00a0al. Global, regional, and national sepsis incidence\u00a0and mortality, 1990\u20132021: a systematic analysis. 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