{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:48:21Z","timestamp":1792500501992,"version":"4.5.0"},"reference-count":27,"publisher":"Akademiai Kiado Zrt.","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["EUJMI"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Capnocytophaga canimorsus<\/jats:italic>\n                    is a fastidious Gram-negative rod transmitted from dog saliva and typically associated with immunocompromised hosts. We report meningitis in a 66-year-old immunocompetent dog owner with prior cerebral amyloid angiopathy who presented with acute global aphasia, fever and inflammatory cerebrospinal fluid (CSF) consistent with bacterial meningitis, but without meningism or history of any dog bite. Fusiform Gram-negative rods in CSF prompted extended culture in thioglycolate broth, enabling growth and subsequent species identification by MALDI-TOF MS as\n                    <jats:italic>C.\u00a0canimorsus<\/jats:italic>\n                    within five days. Antimicrobial susceptibility testing was performed according to EUCAST guidance for situations without species-specific breakpoints and supported continuation of ceftriaxone-based therapy for a total of 15 days, resulting in complete clinical remission and normalization of CSF parameters. This case underlines that\n                    <jats:italic>C. canimorsus<\/jats:italic>\n                    meningitis can occur in apparently immunocompetent elderly patients, illustrates the diagnostic value of targeted culture strategies, and emphasizes the feasibility of EUCAST-guided susceptibility testing for this rare pathogen.\n                  <\/jats:p>","DOI":"10.1556\/1886.2026.00054","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:11:07Z","timestamp":1792498267000},"update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Meningitis of a 66-year-old dog owner caused by Capnocytophaga canimorsus"],"prefix":"10.1556","author":[{"given":"Markus","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Microbiology & Vaccination Center, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"},{"name":"Department of Neurology, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Uibel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"M\u00e4urer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Pauly","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Microbiology & Vaccination Center, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-013X","authenticated-orcid":true,"given":"Andreas E.","family":"Zautner","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Microbiology & Vaccination Center, Klinikum W\u00fcrzburg Mitte gGmbH, W\u00fcrzburg, Germany"},{"name":"Institute of Medical Microbiology and Hospital Hygiene, Faculty of Medicine, Otto-von-Guericke-University, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Sci Rep","article-title":"Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus","volume":"6","author":"Renzi F","year":"2016 Dec 15","unstructured":"Renzi F, Ittig SJ, Sadovskaya I, Hess E, Lauber F, Dol M, et\u00a0al. Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus. Sci Rep. 2016 Dec 15;6:38914."},{"issue":"1","key":"B2","series-title":"Case Rep Neurol","first-page":"269","article-title":"A rare case of Capnocytophaga canimorsus Meningitis in an immunocompetent patient: a successful outcome with a short course of antibiotics","volume":"16","author":"van der Hoeven AE","year":"2024","unstructured":"van der Hoeven AE, Kerremans JJ, Lagrand TJ. A rare case of Capnocytophaga canimorsus Meningitis in an immunocompetent patient: a successful outcome with a short course of antibiotics. Case Rep Neurol. 2024;16(1):269\u201373."},{"issue":"6","key":"B3","series-title":"J\u00a0Clin Microbiol","first-page":"1902","article-title":"Identification of virulent Capnocytophaga canimorsus isolates by capsular typing","volume":"55","author":"Hess E","year":"2017 June","unstructured":"Hess E, Renzi F, Koudad D, Dol M, Cornelis GR. Identification of virulent Capnocytophaga canimorsus isolates by capsular typing. J\u00a0Clin Microbiol. 2017 June;55(6):1902\u201314."},{"issue":"4","key":"B4","series-title":"Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol","first-page":"657","article-title":"Genomic analysis reveals the presence of a class D beta-lactamase with broad substrate specificity in animal bite associated Capnocytophaga species","volume":"36","author":"Zangenah S","year":"2017 Apr","unstructured":"Zangenah S, Andersson AF, \u00d6zenci V, Bergman P. Genomic analysis reveals the presence of a class D beta-lactamase with broad substrate specificity in animal bite associated Capnocytophaga species. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2017 Apr;36(4):657\u201362."},{"issue":"5","key":"B5","series-title":"Cureus","article-title":"Unique presentation of a ubiquitous organism: Capnocytophaga canimorsus Meningitis with pneumocephalus","volume":"16","author":"Grewal N","year":"2024 May","unstructured":"Grewal N, Hager K, Pinelo AC, Duddukunta Y, Tolla GG, Gasmelseed H. Unique presentation of a ubiquitous organism: Capnocytophaga canimorsus Meningitis with pneumocephalus. Cureus. 2024 May;16(5):e59529."},{"issue":"5","key":"B6","series-title":"Plos Pathog","article-title":"The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding","volume":"8","author":"Ittig S","year":"2012","unstructured":"Ittig S, Lindner B, Stenta M, Manfredi P, Zdorovenko E, Knirel YA, et\u00a0al. The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding. Plos Pathog. 2012;8(5):e1002667."},{"issue":"7","key":"B7","series-title":"Open Forum Infect Dis","article-title":"The characteristics of Capnocytophaga infection: 10\u00a0years of experience","volume":"8","author":"Chesdachai S","year":"2021 July","unstructured":"Chesdachai S, Tai DBG, Yetmar ZA, Misra A, Ough N, Abu Saleh O. The characteristics of Capnocytophaga infection: 10\u00a0years of experience. Open Forum Infect Dis. 2021 July;8(7):ofab175."},{"issue":"1","key":"B8","series-title":"BMC Infect Dis","first-page":"696","article-title":"Lethal Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an asplenic patient","volume":"22","author":"Schuler F","year":"2022 Aug 17","unstructured":"Schuler F, Padberg JS, Hullermann C, K\u00fcmpers P, Lepper J, Schulte M, et\u00a0al. Lethal Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an asplenic patient. BMC Infect Dis. 2022 Aug 17;22(1):696."},{"issue":"12","key":"B9","series-title":"Emerg Infect Dis","first-page":"2195","article-title":"Capnocytophaga canimorsus capsular serovar and disease severity, Helsinki hospital district, Finland, 2000-2017","volume":"24","author":"Hess E","year":"2018 Dec","unstructured":"Hess E, Renzi F, Karhunen P, Dol M, Lef\u00e8vre A, Antikainen J, et\u00a0al. Capnocytophaga canimorsus capsular serovar and disease severity, Helsinki hospital district, Finland, 2000-2017. Emerg Infect Dis. 2018 Dec;24(12):2195\u2013201."},{"issue":"5","key":"B10","series-title":"BMJ Case Rep","article-title":"Rare case of Capnocytophaga canimorsus meningitis in a man without risk factors","volume":"14","author":"Malik F","year":"2021 May 28","unstructured":"Malik F, Orchard W, Jacob G. Rare case of Capnocytophaga canimorsus meningitis in a man without risk factors. BMJ Case Rep. 2021 May 28;14(5):e241686."},{"issue":"1","key":"B11","series-title":"BMC Infect Dis","first-page":"100","article-title":"A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic - case report and review of the literature","volume":"20","author":"Prasil P","year":"2020 Feb 3","unstructured":"Prasil P, Ryskova L, Plisek S, Bostik P. A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic - case report and review of the literature. BMC Infect Dis. 2020 Feb 3;20(1):100."},{"issue":"1","key":"B12","series-title":"Infect Dis Ther","first-page":"119","article-title":"Capnocytophaga canimorsus Meningitis: diagnosis using polymerase chain reaction testing and systematic review of the literature","volume":"8","author":"Hansen M","year":"2019 Mar","unstructured":"Hansen M, Crum-Cianflone NF. Capnocytophaga canimorsus Meningitis: diagnosis using polymerase chain reaction testing and systematic review of the literature. Infect Dis Ther. 2019 Mar;8(1):119\u201336."},{"key":"B13","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"e33","article-title":"Meningitis caused by Capnocytophaga canimorsus in a COVID-19 patient: a rare complication of dog bites","volume":"64","author":"Farias LABG","year":"2022","unstructured":"Farias LABG, Stolp \u00c2MV, Bandeira SP, Mesquita RF, Bessa PP de N, et\u00a0al. Meningitis caused by Capnocytophaga canimorsus in a COVID-19 patient: a rare complication of dog bites. Rev Inst Med Trop Sao Paulo. 2022;64:e33."},{"issue":"7","key":"B14","series-title":"Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol","first-page":"1271","article-title":"Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites","volume":"34","author":"Butler T","year":"2015 July","unstructured":"Butler T. Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2015 July;34(7):1271\u201380."},{"issue":"2","key":"B15","series-title":"Przegl Epidemiol","first-page":"289","article-title":"Capnocytophaga\u00a0canimorsus \u2013 an underestimated danger after dog or cat bite \u2013 review of literature","volume":"70","author":"Zajkowska J","year":"2016","unstructured":"Zajkowska J, Kr\u00f3l M, Falkowski D, Syed N, Kamie\u0144ska A. 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