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However, differentially expressed genetic profiling involved in this process is still largely unknown. A rodent version of the gambling task (rGT) has been developed to measure decision-making by adopting the same principle of Iowa Gambling Task in humans. In the present study, we examined using next-generation sequencing (NGS) technique whether there are differences in gene expression profiles in the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAc) when rats make different choices toward risk in rGT.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>Rats were trained in a touch screen chamber to learn the relationships between 4 different light signals on the window of the screen and accompanied reward outcomes or punishments set up with different magnitudes and probabilities. Once they showed a stabilized pattern of preference upon free choice, rats were classified into risk-averse or risk-seeking groups. After performing the rGT, rats were decapitated, the mPFC and the NAc was dissected out, and NGS was performed with the total RNA extracted.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>We found that 477 and 36 genes were differentially expressed (approximately 75 and 83% out of them were downregulated) in the mPFC and the NAc, respectively, in risk-seeking compared to risk-averse rats. Among those, we suggested a few top ranked genes that may contribute to promoting risky choices.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Discussion and conclusions<\/jats:title>\n               <jats:p>Our findings provide insights into transcriptional components underlying risky choices in rats.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1556\/2006.2022.00068","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T15:00:59Z","timestamp":1662994859000},"page":"845-857","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Differential transcriptome profile underlying risky choice in a rat gambling task"],"prefix":"10.1556","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-9936","authenticated-orcid":true,"given":"Myung Ji","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-7012","authenticated-orcid":true,"given":"Wha Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yonsei University College of Medicine, Seoul 03722, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-892X","authenticated-orcid":true,"given":"Seung-Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cancer Evolution Research Center, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"},{"name":"Department of Biomedicine & Health Sciences, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"},{"name":"Precision Medicine Research Center, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-5948","authenticated-orcid":true,"given":"Yeun-Jun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Health Sciences, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"},{"name":"Precision Medicine Research Center, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"},{"name":"Department of Microbiology, IRCGP, The Catholic University of Korea College of Medicine, Seoul 06591, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-3729","authenticated-orcid":true,"given":"Jeong-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, South Korea"},{"name":"Department of Physiology, Yonsei University College of Medicine, Seoul 03722, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Bioinformatics","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders, S.","year":"2015","unstructured":"Anders, S.\n                  , \n                     Pyl, P. 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Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. \n                  Nature Communications\n               , 10, 1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6.3094431310.1038\/s41467-019-09234-6"}],"container-title":["Journal of Behavioral Addictions"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/2006\/11\/3\/article-p845.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/2006\/11\/3\/article-p845.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/2006\/11\/3\/article-p845.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T11:12:49Z","timestamp":1664881969000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/2006\/11\/3\/article-p845.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":61,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/2006.2022.00068","relation":{},"ISSN":["2062-5871","2063-5303"],"issn-type":[{"value":"2062-5871","type":"print"},{"value":"2063-5303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]}}}