{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:25:56Z","timestamp":1790792756274,"version":"4.1.0"},"reference-count":75,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NWO-ZonMw grant VIDI","award":["91713354"],"award-info":[{"award-number":["91713354"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["JBA"],"published-print":{"date-parts":[[2023,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Dysfunction of the striatum, a brain region part of the mesolimbic reward system, is a key characteristic of addictive disorders, but neuroimaging studies have reported conflicting findings. An integrative model of addiction points to the presence or absence of addiction-related cues as an explanation for hyper- or hypoactivation, respectively, of the striatum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To test this model directly, we investigated striatal activation during monetary reward anticipation in the presence versus absence of addiction-related cues using functional MRI. Across two studies, we compared 46 alcohol use disorder (AUD) patients with 30 matched healthy controls; and 24 gambling disorder (GD) patients with 22 matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During monetary reward anticipation, hypoactivation of the reward system was seen in AUD individuals compared to HCs. Additionally, a behavioral interaction was seen where gambling cues made participants, across groups, respond faster for bigger, but slower for smaller rewards. However, no striatal differences were seen in response to addiction-related cues between AUD or GD patients and their matched controls. Finally, despite substantial individual differences in neural activity to cue-reactivity and reward anticipation, these measures did not correlate, suggesting that they contribute independently to addiction aetiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Our findings replicate previous findings of blunted striatal activity during monetary reward anticipation in alcohol use disorder but do not support the idea that addiction-related cues explain striatal dysfunction as suggested by the model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/2006.2023.00015","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T13:27:35Z","timestamp":1683034055000},"page":"571-583","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":5,"title":["Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder"],"prefix":"10.1556","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-8269","authenticated-orcid":true,"given":"Tim","family":"van Timmeren","sequence":"first","affiliation":[{"name":"Department of Social Health and Organizational Psychology, Utrecht University, The Netherlands"},{"name":"ABC Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, 1001 NK, The Netherlands"},{"name":"Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-9355","authenticated-orcid":true,"given":"Ruth J.","family":"van Holst","sequence":"additional","affiliation":[{"name":"ABC Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, 1001 NK, The Netherlands"},{"name":"Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-9384","authenticated-orcid":true,"given":"Anna E.","family":"Goudriaan","sequence":"additional","affiliation":[{"name":"ABC Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, 1001 NK, The Netherlands"},{"name":"Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands"},{"name":"Arkin Mental Health, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"5","key":"B1","series-title":"Biological Psychiatry","first-page":"434","article-title":"Anticipatory reward processing in addicted populations: A focus on the monetary incentive delay task","volume":"77","author":"Balodis, I. 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