{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:35:04Z","timestamp":1770291304869,"version":"3.49.0"},"reference-count":35,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["JBA"],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.<\/jats:p>","DOI":"10.1556\/2006.2023.00075","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:06:03Z","timestamp":1705313163000},"page":"16-20","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":5,"title":["Genetics of gambling disorder and related phenotypes: The potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes"],"prefix":"10.1556","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-8571","authenticated-orcid":true,"given":"Varun","family":"Warrier","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-8121","authenticated-orcid":true,"given":"Samuel R","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Southampton, Southern Health NHS Foundation Trust, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-6022","authenticated-orcid":true,"given":"Shane A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Vice Chancellor's Office and Institute of Health and Wellbeing, Federation University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-3697","authenticated-orcid":true,"given":"Henrietta","family":"Bowden-Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"},{"name":"National Problem Gambling Clinic & National Centre for Gaming Disorders, London, UK"},{"name":"Department of Brain Sciences, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association (2013). 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