{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:50:36Z","timestamp":1782391836860,"version":"3.54.5"},"reference-count":298,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["JBA"],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"Abstract<\/jats:title>\n \n Background and aims<\/jats:title>\n Dysregulation in instrumental control systems is implicated in compulsivity, a transdiagnostic construct proposed to underlie diverse maladaptive behaviors. While habit formation in reward-based learning is well-characterized, its role in avoidance learning remains less understood. Habitual avoidance may contribute to compulsive symptoms by impairing emotion regulation, a well-established correlate of compulsivity. To define these mechanisms, this study examined negative emotionality as a pathway linking habitual avoidance to compulsive behaviors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Five hundred adults completed the Avoidance Dynamics Task (ADT), a novel online-administered aversive devaluation paradigm assessing avoidance learning and habit strength, alongside validated self-report measures of compulsive behaviors (alcohol use, binge eating, binge watching, gambling, obsessive-compulsive symptoms) and internalizing symptoms (depression, anxiety). Mediation analysis tested whether internalizing symptoms accounted for associations between habitual avoidance and compulsive behavior severity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Habitual avoidance, indexed by perseverative responses to devalued threat versus control cues (\n t<\/jats:italic>\n = 3.5,\n p<\/jats:italic>\n = .002), showed small-to-moderate positive associations with avoidance urges (\n \u03c1<\/jats:italic>\n = .28,\n p<\/jats:italic>\n < .001), regulatory control deficits (\n \u03c1<\/jats:italic>\n = .17,\n p<\/jats:italic>\n < .001), and internalizing symptoms (\n b<\/jats:italic>\n \u00a0= .15,\n p<\/jats:italic>\n = .004). Internalizing symptoms fully mediated associations with all compulsive behaviors (\n b<\/jats:italic>\n 's = .05\u2013.16, all\n p<\/jats:italic>\n \u2264 .01). Impaired avoidance learning was modestly associated with greater alcohol use (\n b<\/jats:italic>\n = \u2212.12,\n p<\/jats:italic>\n = .03) and gambling (\n b<\/jats:italic>\n = \u2212.15,\n p<\/jats:italic>\n = .02) severity. Exploratory analyses showed distinct avoidance patterns mapped onto cognitive (preoccupation, urges) versus behavioral (control, frequency) components of alcohol-related compulsivity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Habitual avoidance may represent a transdiagnostic behavioral marker of compulsivity. These findings underscore distinct vulnerability pathways across compulsive domains and support the use of remote tasks to phenotype maladaptive avoidance and related emotional dysregulation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1556\/2006.2025.00089","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:17:14Z","timestamp":1763551034000},"page":"1517-1532","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Mapping affective pathways to compulsion: Insights from an aversive devaluation approach"],"prefix":"10.1556","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-3995","authenticated-orcid":true,"given":"Samantha N.","family":"Sallie","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-3093","authenticated-orcid":true,"given":"Violeta","family":"Casero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-0579","authenticated-orcid":true,"given":"Saurabh","family":"Sonkusare","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-1776","authenticated-orcid":true,"given":"Valerie","family":"Voon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"},{"name":"Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"2","key":"B1","series-title":"The Quarterly Journal of Experimental Psychology Section B","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/14640748108400816","article-title":"Instrumental responding following reinforcer devaluation","volume":"33","author":"Adams, C. 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