{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:35:33Z","timestamp":1777599333339,"version":"3.51.4"},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["J Behav Addict"],"published-print":{"date-parts":[[2018,9,21]]},"abstract":"\n Introduction<\/jats:title>\n Gambling disorder (GD) is a major public health concern with currently no validated and efficacious treatments approved. In this single case study, we report the short- and long-term effect of bilateral transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) on craving and impulse control in a subject with GD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The patient is a 26-year-old Caucasian male with an 8-year history of GD as well as alcohol and cocaine misuse. Treatment consisted of twice-a-day stimulation for 10 days. According to the literature, both the left (to control craving) and the right (to control emotional impulses) DLPFC were stimulated. Patients subsequently received tDCS once a week for 3 months and then once every 2 weeks for another 3 months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After 10 days of treatment, the subject reported improved psychiatric symptoms (depression, anxiety, and impulsivity), as well as reduced gambling craving symptom severity. After 3 and 6 months of treatment, the clinical picture further improved.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This is the first report of tDCS effectiveness in a single case study of GD. Therapeutic effects, both on the addictive behavior and on psychiatric comorbid symptomatology, were lasting and continued over 6 months of tDCS maintenance treatment. Future case\u2013control studies are required to test the efficacy of this tool in patients with GD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1556\/2006.7.2018.85","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T12:22:02Z","timestamp":1538742122000},"page":"834-837","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":17,"title":["Gambling disorder and bilateral transcranial direct current stimulation: A case report"],"prefix":"10.1556","volume":"7","author":[{"given":"Giovanni","family":"Martinotti","sequence":"first","affiliation":[{"name":"1 Department of Neuroscience, Imaging and Clinical Sciences, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy"},{"name":"2 Department of Pharmacy, Pharmacology, Clinical Science, University of Hertfordshire, Herts, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Chillemi","sequence":"additional","affiliation":[{"name":"3 SRP \u201cVilla Maria Pia\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Lupi","sequence":"additional","affiliation":[{"name":"1 Department of Neuroscience, Imaging and Clinical Sciences, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa De","family":"Risio","sequence":"additional","affiliation":[{"name":"4 Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Pettorruso","sequence":"additional","affiliation":[{"name":"1 Department of Neuroscience, Imaging and Clinical Sciences, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo Di","family":"Giannantonio","sequence":"additional","affiliation":[{"name":"1 Department of Neuroscience, Imaging and Clinical Sciences, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref241","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5498\/wjp.v5.i1.88","article-title":"Transcranial direct current stimulation in psychiatric disorders","volume":"5","author":"Tortella","year":"2015","journal-title":"World Journal of Psychiatry,"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.biopsych.2012.01.006","article-title":"Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling","volume":"71","author":"Balodis","year":"2012","journal-title":"Biological 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