{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T17:58:00Z","timestamp":1715191080049},"reference-count":64,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2016,12,22]]},"abstract":"<jats:sec sec-type=\"background\">\n          <jats:title>Background<\/jats:title>\n          <jats:p>Type 2 diabetes mellitus (T2DM)-induced neuropathy and ischemia-reperfusion post-surgery prolong carpal tunnel syndrome (CTS) pathology, but the effect of T2DM on the prognostic outcome of carpal tunnel (CT) release surgery needs to be investigated.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"materials and methods\">\n          <jats:title>Materials and methods<\/jats:title>\n          <jats:p> A total of 64 individuals with CTS underwent CT release surgery. HbA1c levels identified their diabetic status. The individual prognostic outcomes were measured by nerve conduction velocity (NCV), amplitude, and latency. Measurement of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub> and reactive oxygen species (ROS) from isolated endothelial cells (ECs) revealed the oxidative burden of the normal and diabetic CTS phenotypes.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"results\">\n          <jats:title>Results<\/jats:title>\n          <jats:p>CTS individuals with HbA1c\u2009&gt;\u20097 showed decreased NCV (\u224822\u00a0m\/s) and amplitude (\u22484.2\u00a0mV) with increased latency (\u22486\u00a0ms), compared to groups with HbA1c\u2009\u2264\u20097. Further to CT release surgery, the reversal of the nerve conduction to normalcy was greatly influenced by the diabetic profile of the individuals. Our results showed elevated basal [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub> and corresponding high cytosolic ROS in the ECs isolated from individuals with HbA1c\u2009&gt;\u20097 compared to the diabetic and healthy control groups.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"conclusion\">\n          <jats:title>Conclusion<\/jats:title>\n          <jats:p>The individuals with diabetic index showed suboptimal neuronal performance pre- and post-CT release surgery. Oxidative stress mediated by high [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub> and ROS of ECs dissipates to adjoining cells worsening the pathology of the untreated CTS.<\/jats:p>\n        <\/jats:sec>","DOI":"10.1556\/2060.103.2016.4.1","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T07:56:22Z","timestamp":1482911782000},"page":"469-480","source":"Crossref","is-referenced-by-count":2,"title":["Elevated basal cytosolic calcium of endothelial cells influences the post-surgical outcome in diabetic CTS"],"prefix":"10.1556","volume":"103","author":[{"given":"IM","family":"Bin-Jaliah","sequence":"first","affiliation":[{"name":"1 Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEA","family":"Shariff","sequence":"additional","affiliation":[{"name":"1 Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia"},{"name":"2 Department of Orthopedics, Jubilee Mission Medical College, Thrissur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PS","family":"Nayar","sequence":"additional","affiliation":[{"name":"2 Department of Orthopedics, Jubilee Mission Medical College, Thrissur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HC","family":"Chandramoorthy","sequence":"additional","affiliation":[{"name":"3 Department of Microbiology and Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref111","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1212\/WNL.58.11.1589","article-title":"Electrodiagnostic studies in carpal tunnel syndrome","volume":"58,","author":"Jablecki","year":"2002","journal-title":"Neurology"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.orthres.2004.03.005","article-title":"Vascular pathologic changes in the flexor tenosynovium (subsynovial connective tissue) in idiopathic carpal tunnel syndrome","volume":"22,","author":"Jinrok","year":"2004","journal-title":"J. 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J. Clin. Pract."},{"key":"ref61","first-page":"191","article-title":"Shoulder pain pathogenesis","volume-title":"Clinical Concepts in Regional Musculoskeletal Illness,","author":"Hagberg","year":"1987"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/1119-3077.175971","article-title":"The role of neoangiogenesis and vascular endothelial growth factor in the development of carpal tunnel syndrome in patients with diabetes","volume":"19,","author":"Deger","year":"2016","journal-title":"Niger. J. Clin. Pract."},{"key":"ref651","doi-asserted-by":"crossref","first-page":"e27715","DOI":"10.1371\/journal.pone.0027715","article-title":"Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object weight for whole-hand manipulation","volume":"6,","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000069824","article-title":"Bilateral carpal tunnel syndrome with type 1 diabetes mellitus in childhood","volume":"38,","author":"Kayali","year":"2003","journal-title":"Pediatr. Neurosurg."},{"key":"ref571","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/dme.12855","article-title":"Diabetes as a risk factor for carpal tunnel syndrome: systematic review and meta-analysis","volume":"33,","author":"Pourmemari","year":"2016","journal-title":"Diabet. 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Res."},{"key":"ref221","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/acm.2016.0083","article-title":"The effects of oscillatory biofield therapy on pain and functional limitations associated with carpal tunnel syndrome: randomized, placebo-controlled, double-blind study","volume":"22,","author":"Nourbakhsh","year":"2016","journal-title":"J. Altern. Complement. Med."},{"key":"ref591","first-page":"28","article-title":"Carpal tunnel syndrome: primary care and occupational factors","volume":"2,","author":"Saint-Lary","year":"2015","journal-title":"Front. Med. (Lausanne)"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.rbo.2013.08.007","article-title":"Carpal tunnel syndrome \u2013 part I (anatomy, physiology, etiology and diagnosis).","volume":"49,","author":"Chammas","year":"2014","journal-title":"Rev. Bras. Ortop."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/path.1673","article-title":"The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome","volume":"204,","author":"Hirata","year":"2004","journal-title":"J. Pathol."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00441-014-2034-2","article-title":"Differentiated mesenchymal stem cells ameliorate cardiovascular complications in diabetic rats","volume":"359,","author":"Haidara","year":"2015","journal-title":"Cell Tissue Res."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1515\/CCLM.2002.016","article-title":"Approved IFCC reference method for the measurement of HbA1c in human blood","volume":"40,","author":"Jeppsson","year":"2002","journal-title":"Clin. Chem. Lab. 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J. Biomed. Adv. Res."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.rbo.2013.08.007","article-title":"Carpal tunnel syndrome \u2013 part I (anatomy, physiology, etiology and diagnosis).","volume":"49,","author":"Chammas","year":"2014","journal-title":"Rev. Bras. Ortop."},{"key":"ref611","first-page":"1","article-title":"Exercise-induced muscle fatigue: the significance of potassium","volume":"593,","author":"Sj\u00f8gaard","year":"1990","journal-title":"Acta Physiol. Scand. 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