{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:35:27Z","timestamp":1648521327427},"reference-count":34,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2016,12,22]]},"abstract":"<jats:p>The effects of moderate hypothermia (28\u00a0\u00b0C) on the response of human varicose spermatic vein to \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration\u2013response curves for phenylephrine (10<jats:sup>\u22129<\/jats:sup> to 3\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup> M) were recorded in rings with and without endothelium at 37 and 28\u00a0\u00b0C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N<jats:sup>G<\/jats:sup>-nitro-<jats:sc>L<\/jats:sc>-arginine methyl ester (10<jats:sup>\u22124<\/jats:sup> M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28\u00a0\u00b0C than at 37\u00a0\u00b0C. There was no significant difference in phenylephrine response at 28 and 37\u00a0\u00b0C in vessels without endothelium but at 28\u00a0\u00b0C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10<jats:sup>\u22129<\/jats:sup> to 3\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.<\/jats:p>","DOI":"10.1556\/2060.103.2016.4.2","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T07:56:22Z","timestamp":1482911782000},"page":"481-486","source":"Crossref","is-referenced-by-count":1,"title":["Moderate hypothermia attenuates \u03b11-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)"],"prefix":"10.1556","volume":"103","author":[{"given":"KE","family":"Nurullahoglu-Atalik","sequence":"first","affiliation":[{"name":"1 Department of Pharmacology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cenker","sequence":"additional","affiliation":[{"name":"2 Department of Urology, Medline Hospital, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref261","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1476-5381.1991.tb12477.x","article-title":"Response of rabbit ear artery to endothelin-1 during cooling","volume":"104,","author":"Monge","year":"1991","journal-title":"Br. 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