{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:58:52Z","timestamp":1751468332208},"reference-count":94,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2016,12,22]]},"abstract":"<jats:p>This study aimed to assess the role of H<jats:sub>2<\/jats:sub>S in homocysteine-induced cardiodynamic effects in the isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique. The maximum and minimum rates of pressure in the left ventricle (dp\/dt max, dp\/dt min), systolic and diastolic left ventricular pressures (SLVP, DLVP), heart rate (HR), and coronary flow (CF) were measured. A spectrophotometrical method was used to measure the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), nitrite level (NO<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>), superoxide anion radicals (O<jats:sub>2<\/jats:sub><jats:sup>\u2022\u2212<\/jats:sup>), and hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) concentrations. The administration of 10\u00a0\u00b5mol\/l DL-homocysteine (DL-Hcy) alone decreased dp\/dt max, SLVP, and CF but did not change any oxidative stress parameters. The administration of 10\u00a0\u00b5mol\/l DL-propargylglycine (DL-PAG) decreased all cardiodynamic parameters and increased the concentration of O<jats:sub>2<\/jats:sub><jats:sup>\u2022\u2212<\/jats:sup>. The co-administration of DL-Hcy and DL-PAG induced a significant decrease in all estimated cardiodynamic parameters and decreased the concentration of NO<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> and O<jats:sub>2<\/jats:sub><jats:sup>\u2022\u2212<\/jats:sup> but increased the levels of TBARS and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Homocysteine shows a lower pro-oxidative effect in the presence of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), which indicates a potential anti-oxidative capacity of H<jats:sub>2<\/jats:sub>S.<\/jats:p>","DOI":"10.1556\/2060.103.2016.4.3","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T07:56:22Z","timestamp":1482911782000},"page":"428-438","source":"Crossref","is-referenced-by-count":4,"title":["The role of hydrogen sulfide in homocysteine-induced cardiodynamic effects and oxidative stress markers in the isolated rat heart"],"prefix":"10.1556","volume":"103","author":[{"given":"M","family":"Stojanovic","sequence":"first","affiliation":[{"name":"1 Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"1 Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Srejovic","sequence":"additional","affiliation":[{"name":"1 Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"1 Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Jeremic","sequence":"additional","affiliation":[{"name":"2 Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Djuric","sequence":"additional","affiliation":[{"name":"3 Institute of Medical Physiology \u201cRichard Burian\u201d, School of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref291","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114,","author":"Polhemus","year":"2014","journal-title":"Circ. 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