{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T14:23:58Z","timestamp":1648563838925},"reference-count":54,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2018,9,28]]},"abstract":"<jats:sec sec-type=\"purpose\">\n          <jats:title>Purpose<\/jats:title>\n          <jats:p>This study was performed to investigate the influence of \u03b1-adrenoceptor subtypes upon ureteral smooth muscle contractile responses.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"methods\">\n          <jats:title>Methods<\/jats:title>\n          <jats:p>Rat ureters were challenged <jats:italic>in vitro<\/jats:italic> with noradrenaline (NA), the \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor agonist phenylephrine (PE), and the \u03b1<jats:sub>2<\/jats:sub>-adrenoceptor agonist clonidine (CLON). The influences of the agonists on the magnitude and frequency of acetylcholine (ACh)-stimulated phasic contractile responses were recorded.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"results\">\n          <jats:title>Results<\/jats:title>\n          <jats:p>The magnitude of the phasic contractile responses effected by ACh was not significantly influenced by the adrenoceptor agonists, but the frequency of the response was significantly enhanced by all three agonists (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Idazoxan and prazosin abolished the rise in frequency effected by CLON and PE, respectively, whereas both antagonists in combination were required to abolish the increase in frequency effected by NA.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec sec-type=\"conclusions\">\n          <jats:title>Conclusions<\/jats:title>\n          <jats:p>It has been demonstrated that \u03b1<jats:sub>1<\/jats:sub>- and \u03b1<jats:sub>2<\/jats:sub>-adrenoceptors modulate the contractile function of rat ureteral smooth muscle by increasing the frequency, but not the magnitude, of phasic contractile responses. The enhancement of contractile function by NA is mediated by mechanisms dependent upon both \u03b1<jats:sub>1<\/jats:sub>- and \u03b1<jats:sub>2<\/jats:sub>-adrenoceptors.<\/jats:p>\n        <\/jats:sec>","DOI":"10.1556\/2060.105.2018.3.19","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T12:18:39Z","timestamp":1538741919000},"page":"225-232","source":"Crossref","is-referenced-by-count":0,"title":["The modulation of ureteral smooth muscle contractile responses by \u03b11- and \u03b12-adrenoceptor activation"],"prefix":"10.1556","volume":"105","author":[{"given":"DR","family":"Monks","sequence":"first","affiliation":[{"name":"1 UCD School of Medicine, Health Sciences Centre, University College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Bund","sequence":"additional","affiliation":[{"name":"1 UCD School of Medicine, Health Sciences Centre, University College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref351","first-page":"312487","article-title":"The inhibition of ureteral motility by periureteral adipose tissue","volume":"2012","author":"Killian","year":"2012","journal-title":"ISRN Urol."},{"key":"ref291","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/apha.12392","article-title":"Electrical propagation in the renal pelvis, ureter and bladder","volume":"213","author":"Hammad","year":"2015","journal-title":"Acta Physiol. (Oxf)."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00383-002-0721-7","article-title":"Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract","volume":"18","author":"Rolle","year":"2002","journal-title":"Pediatr. Surg. Int."},{"key":"ref391","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1582-4934.2005.tb00487.x","article-title":"Interstitial cell of Cajal-like cells in the upper urinary tract","volume":"9","author":"Lang","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1097\/01.ju.0000133557.39515.b6","article-title":"Pharmacological characterization of beta-adrenoceptor subtypes mediating relaxation in porcine isolated ureteral smooth muscle","volume":"172","author":"Wanajo","year":"2004","journal-title":"J. Urol."},{"key":"ref531","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2015.02.031","article-title":"Functional effects of \u03b23-adrenoceptor on pacemaker activity in interstitial cells of Cajal from the mouse colon","volume":"754","author":"Wu","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00586738","article-title":"The effect of catecholamines on ureteral peristalsis in different species (dog, guinea-pigs and rat)","volume":"350","author":"Hannapel","year":"1974","journal-title":"Pflugers Arch."},{"key":"ref61","first-page":"38","article-title":"Ureteric vascular and muscle coat innervation in the rat. A quantitative ultrastructural study","volume":"14","author":"Hoyes","year":"1976","journal-title":"Invest. 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Pharmacol."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00441-013-1572-3","article-title":"Interstitial cells of Cajal mediate excitatory sympathetic neurotransmission in guinea pig prostate","volume":"352","author":"Wang","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1476-5381.1992.tb13387.x","article-title":"Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors","volume":"107","author":"Hern\u00e1ndez","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1113\/jphysiol.1972.sp009866","article-title":"Preliminary observations on the mechanical and electrical activity of the rat ureter","volume":"223","author":"Tindall","year":"1972","journal-title":"J. Physiol."},{"key":"ref111","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1540\/jsmr.45.187","article-title":"Effects of four different \u03b11-adrenoceptor antagonists on \u03b1-adrenoceptor agonist-induced contractions in isolated mouse and hamster ureters","volume":"45","author":"Kobayashi","year":"2009","journal-title":"J. Smooth Muscle Res."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/apha.12392","article-title":"Electrical propagation in the renal pelvis, ureter and bladder","volume":"213","author":"Hammad","year":"2015","journal-title":"Acta Physiol. (Oxf)."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/sj.bjp.0705665","article-title":"Noradrenaline inhibits pacemaker currents through stimulation of beta 1-adrenoceptors in cultured interstitial cells of Cajal from murine small intestine","volume":"141","author":"Jun","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1464-410X.2008.07630.x","article-title":"Changes to the contractile function of ureter smooth muscle after partial infravesical obstruction in fetal sheep","volume":"102","author":"Nyir\u00e1dy","year":"2008","journal-title":"BJU Int."},{"key":"ref121","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1582-4934.2005.tb00487.x","article-title":"Interstitial cell of Cajal-like cells in the upper urinary tract","volume":"9","author":"Lang","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1113\/jphysiol.2006.116657","article-title":"Organization and function of ICC in the urinary tract","volume":"576","author":"McHale","year":"2006","journal-title":"J. Physiol."},{"key":"ref301","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00586738","article-title":"The effect of catecholamines on ureteral peristalsis in different species (dog, guinea-pigs and rat)","volume":"350","author":"Hannapel","year":"1974","journal-title":"Pflugers Arch."},{"key":"ref481","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1113\/jphysiol.1972.sp009866","article-title":"Preliminary observations on the mechanical and electrical activity of the rat ureter","volume":"223","author":"Tindall","year":"1972","journal-title":"J. Physiol."},{"key":"ref491","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-2999(98)00360-4","article-title":"Beta-adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs","volume":"352","author":"Tomiyama","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/sj.bjp.0705665","article-title":"Noradrenaline inhibits pacemaker currents through stimulation of beta 1-adrenoceptors in cultured interstitial cells of Cajal from murine small intestine","volume":"141","author":"Jun","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref151","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-5347(17)43904-8","article-title":"Ureteral urine transport: changes in bolus volume, peristaltic frequency, intraluminal pressure and volume of flow resulting from autonomic drugs","volume":"137","author":"Morita","year":"1987","journal-title":"J. Urol."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00345-009-0396-y","article-title":"Gene expressions and mechanical functions of \u03b11-adrenoceptor subtypes in mouse ureter","volume":"27","author":"Kobayashi","year":"2009","journal-title":"World J. Urol."},{"key":"ref101","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.urology.2009.01.009","article-title":"Mechanical function and gene expression of alpha(1)-adrenoceptor subtypes in dog intravesical ureter","volume":"74","author":"Kobayashi","year":"2009","journal-title":"Urology"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"e12917","DOI":"10.1111\/ijcp.12917","article-title":"Alpha blockers in the management of ureteric lithiasis: a meta-analysis","volume":"71","author":"Raison","year":"2017","journal-title":"Int. J. Clin. Pract."},{"key":"ref411","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1113\/jphysiol.2006.116657","article-title":"Organization and function of ICC in the urinary tract","volume":"576","author":"McHale","year":"2006","journal-title":"J. Physiol."},{"key":"ref221","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-2999(98)00360-4","article-title":"Beta-adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs","volume":"352","author":"Tomiyama","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02549510","article-title":"The morphological basis of ureteral peristalsis. An ultrastructural study of the rat ureter","volume":"20","author":"Aragona","year":"1988","journal-title":"Int. Urol. Nephrol."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02549510","article-title":"The morphological basis of ureteral peristalsis. An ultrastructural study of the rat ureter","volume":"20","author":"Aragona","year":"1988","journal-title":"Int. Urol. Nephrol."},{"key":"ref181","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00383-002-0721-7","article-title":"Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract","volume":"18","author":"Rolle","year":"2002","journal-title":"Pediatr. Surg. Int."},{"key":"ref471","doi-asserted-by":"crossref","first-page":"e86207","DOI":"10.1371\/journal.pone.0086207","article-title":"Ureter smooth muscle cell orientation in rat is predominantly longitudinal","volume":"9","author":"Spronk","year":"2014","journal-title":"PLoS One"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1464-410X.2008.07630.x","article-title":"Changes to the contractile function of ureter smooth muscle after partial infravesical obstruction in fetal sheep","volume":"102","author":"Nyir\u00e1dy","year":"2008","journal-title":"BJU Int."},{"key":"ref281","first-page":"57","article-title":"Histochemical and electron microscopic observations on the innervation of the upper segment of the mammalian ureter","volume":"110","author":"Dixon","year":"1971","journal-title":"J. Anat."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1476-5381.1992.tb13387.x","article-title":"Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors","volume":"107","author":"Hern\u00e1ndez","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-5347(17)43904-8","article-title":"Ureteral urine transport: changes in bolus volume, peristaltic frequency, intraluminal pressure and volume of flow resulting from autonomic drugs","volume":"137","author":"Morita","year":"1987","journal-title":"J. Urol."},{"key":"ref81","first-page":"312487","article-title":"The inhibition of ureteral motility by periureteral adipose tissue","volume":"2012","author":"Killian","year":"2012","journal-title":"ISRN Urol."}],"container-title":["Physiology International"],"original-title":[],"link":[{"URL":"https:\/\/www.akademiai.com\/doi\/full-xml\/10.1556\/2060.105.2018.3.19","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/view\/journals\/2060\/105\/3\/article-p225.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akademiai.com\/doi\/full\/10.1556\/2060.105.2018.3.19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:20:23Z","timestamp":1644546023000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/2060.105.2018.3.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/2060.105.2018.3.19","relation":{},"ISSN":["2498-602X"],"issn-type":[{"value":"2498-602X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}