{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:57:08Z","timestamp":1792133828522,"version":"4.4.0"},"reference-count":66,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>Prenatal hypoxia\u2013ischemia (HI) is a major cause of mortality and chronic neurological diseases in newborns. HI contributes to the emergence of several neurological disorders such as cognitive and behavioral deficits due to the atypical brain development. This study aimed at assessing the effects of prenatal HI on the spatial memory and aggression of rats during adolescence. Pregnant rats were divided into treatment and control groups. The rats of the treatment groups underwent unilateral ligation of the uterine artery on pregnancy day 7, 12, or 17. The offspring of these rats were tested for spatial memory and aggression when they reached 33 days of age. It has been found that the percentages of alternations in the Y-maze and the number of crossings in the Morris water maze tests of the HI groups were lower than those of the control groups<jats:sub>.<\/jats:sub> The total offense and defense aggression scores of the HI groups were higher than those of the control groups. In conclusion, the longer the duration of HI, the more deficits it causes in the spatial memory and aggression of rats during adolescence.<\/jats:p>","DOI":"10.1556\/2060.105.2018.3.21","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T12:18:39Z","timestamp":1538741919000},"page":"210-224","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal hypoxia\u2013ischemia decreases spatial memory and increases aggression during adolescence"],"prefix":"10.1556","volume":"105","author":[{"given":"R","family":"Indriawati","sequence":"first","affiliation":[{"name":"1 Faculty of Medicine, Public Health, and Nursing, Department of Physiology, Universitas Gadjah Mada, Yogyakarta, Indonesia"},{"name":"2 Faculty of Medicine and Health Sciences, Department of Physiology, Universitas Muhammadiyah, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aswin","sequence":"additional","affiliation":[{"name":"3 Faculty of Medicine, Public Health, and Nursing, Department of Anatomy, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Susilowati","sequence":"additional","affiliation":[{"name":"4 Faculty of Medicine, Public Health, and Nursing, Department of Histology and Cell Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Partadiredja","sequence":"additional","affiliation":[{"name":"1 Faculty of Medicine, Public Health, and Nursing, Department of Physiology, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref421","first-page":"718","article-title":"Specificity of ontogenic development of behavior of rats subjected to prenatal hypoxia on the 14-th or 18-th days of embryogenesis","volume":"58","author":"Dubrovskaia","year":"2008","journal-title":"Zh. 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