{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:17:10Z","timestamp":1781540230504,"version":"3.54.5"},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol Hung"],"published-print":{"date-parts":[[2018,12,20]]},"abstract":"\n Purpose<\/jats:title>\n Gastritis is found to be one of the most common gastrointestinal diseases worldwide. However, current therapeutic agents cause side effects, interaction, and recurrence. Allantoin has anti-inflammatory and wound healing properties. In this study, the therapeutic effect of allantoin has been assessed on the histopathological indices and gastric mucosal barrier of male rats.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Male rats were equally divided into control, ethanol-induced gastritis, and allantoin groups. The therapeutic groups consisted of gastritis plus 12.5\u00a0mg\/kg allantoin, gastritis plus 25\u00a0mg\/kg allantoin, and gastritis plus 50\u00a0mg\/kg allantoin groups. After 5\u00a0days of allantoin administration, the rats were sacrificed and a part of their gastric tissue was maintained at \u221270\u00a0\u00b0C for prostaglandin E2 (PGE2) and non-protein sulfhydryl (NP-SH) measurements. Another part was stained with hematoxylin and eosin and Masson\u2019s trichrome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We found that Allantoin increased parietal and mucosal cell counts and mucosal thickness after gastritis induction. In addition, the number of leukocytes and vessels decreased in both of the mucosal and the submucosal layers. Allatoin improved gastric ulcer in all treatment groups. Gastric levels of PGE2 and NP-SH increased after allantoin treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study indicated that allantoin had a considerable effect on gastritis treatment, which seems to result from the reinforcement of gastric mucosal barrier.<\/jats:p>\n <\/jats:sec>","DOI":"10.1556\/2060.105.2018.4.30","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T06:49:32Z","timestamp":1545634172000},"page":"325-334","source":"Crossref","is-referenced-by-count":15,"title":["Allantoin improves histopathological evaluations in a rat model of gastritis"],"prefix":"10.1556","volume":"105","author":[{"given":"M","family":"Eslami-farsani","sequence":"first","affiliation":[{"name":"1 School of Medicine, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moslehi","sequence":"additional","affiliation":[{"name":"2 Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hatami-shahmir","sequence":"additional","affiliation":[{"name":"3 Student Research Committee, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.09.019","article-title":"Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats","volume":"278","author":"Liu","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2017.12.052","article-title":"Effect of allantoin on experimentally induced gastric ulcers: pathways of gastroprotection","volume":"821","author":"da Silva","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref281","article-title":"Chrysophyllumcainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models","author":"da Rosa","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4068\/cmj.2014.50.1.6","article-title":"Gastroprotective effects of glutinous rice extract against ethanol, indomethacin, and stress-induced ulcers in rats","volume":"50","author":"Song","year":"2014","journal-title":"Chonnam Med. J."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1248\/bpb.b15-00642","article-title":"Protective effects of Manassantin A against ethanol-induced gastric injury in rats","volume":"39","author":"Song","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1248\/bpb.b15-00642","article-title":"Protective effects of Manassantin A against ethanol-induced gastric injury in rats","volume":"39","author":"Song","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref231","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2013.11.033","article-title":"Effects of allantoin on cognitive function and hippocampal neurogenesis","volume":"64","author":"Ahn","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"589309","DOI":"10.1155\/2013\/589309","article-title":"Decrease of obesity by Allantoin via Imidazoline I1-receptor activation in high fat diet-fed mice","volume":"2013","author":"Chung","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref181","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.fct.2013.01.019","article-title":"Protective effect of silymarin against ethanol-induced gastritis in rats: role of sulfhydryls, nitric oxide and gastric sensory afferents","volume":"55","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12906-017-1992-9","article-title":"Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats","volume":"17","author":"Halim","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.09.016","article-title":"Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice","volume":"189","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"ref301","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jep.2016.04.010","article-title":"Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice","volume":"186","author":"Florentino","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref361","first-page":"696","article-title":"The effects of a topical gel containing chitosan, 0, 2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction","volume":"21","author":"Madrazo-Jim\u00e9nez","year":"2016","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1055\/s-0032-1312624","article-title":"Stimulatory effect of allantoin on imidazoline I1 receptors in animal and cell line","volume":"44","author":"Yang","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"ref381","first-page":"191","article-title":"Traffic noise exposure increases gastric pepsin secretion in rat","volume":"54","author":"Moslehi","year":"2016","journal-title":"Acta Med. Iran."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jep.2016.04.010","article-title":"Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice","volume":"186","author":"Florentino","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref51","article-title":"Chrysophyllumcainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models","author":"da Rosa","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref261","first-page":"690135","article-title":"Antihypertensive action of allantoin in animals","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref291","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2017.12.052","article-title":"Effect of allantoin on experimentally induced gastric ulcers: pathways of gastroprotection","volume":"821","author":"da Silva","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref221","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.09.016","article-title":"Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice","volume":"189","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"ref401","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10616-013-9594-y","article-title":"Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage","volume":"66","author":"Ozbayer","year":"2014","journal-title":"Cytotechnology"},{"key":"ref151","first-page":"191","article-title":"Traffic noise exposure increases gastric pepsin secretion in rat","volume":"54","author":"Moslehi","year":"2016","journal-title":"Acta Med. Iran."},{"key":"ref171","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10616-013-9594-y","article-title":"Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage","volume":"66","author":"Ozbayer","year":"2014","journal-title":"Cytotechnology"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/08923973.2017.1379088","article-title":"The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation","volume":"39","author":"Li","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref241","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.intimp.2016.03.006","article-title":"Gastroprotective effect of 2-mercaptoethanesulfonate against acute gastric mucosal damage induced by ethanol","volume":"34","author":"Amirshahrokhi","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref311","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12906-017-1992-9","article-title":"Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats","volume":"17","author":"Halim","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"ref31","first-page":"690135","article-title":"Antihypertensive action of allantoin in animals","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref131","first-page":"696","article-title":"The effects of a topical gel containing chitosan, 0, 2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction","volume":"21","author":"Madrazo-Jim\u00e9nez","year":"2016","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1590\/S0102-86502010000500014","article-title":"Profile of wound healing process induced by allantoin","volume":"25","author":"Ara\u00fajo","year":"2010","journal-title":"Acta Cir. Bras."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1590\/S0102-86502010000500014","article-title":"Profile of wound healing process induced by allantoin","volume":"25","author":"Ara\u00fajo","year":"2010","journal-title":"Acta Cir. Bras."},{"key":"ref161","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1556\/APhysiol.101.2014.4.5","article-title":"Protective effect of ghrelin in a rat model of celiac disease","volume":"101","author":"Nikoukar","year":"2014","journal-title":"Acta Physiol. Hung."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"589309","DOI":"10.1155\/2013\/589309","article-title":"Decrease of obesity by Allantoin via Imidazoline I1-receptor activation in high fat diet-fed mice","volume":"2013","author":"Chung","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.intimp.2010.01.008","article-title":"Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma","volume":"10","author":"Lee","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref411","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.fct.2013.01.019","article-title":"Protective effect of silymarin against ethanol-induced gastritis in rats: role of sulfhydryls, nitric oxide and gastric sensory afferents","volume":"55","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/08923973.2017.1379088","article-title":"The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation","volume":"39","author":"Li","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12275-017-7089-9","article-title":"N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection","volume":"55","author":"Jang","year":"2017","journal-title":"J. Microbiol."},{"key":"ref371","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cbi.2009.04.006","article-title":"Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion","volume":"180","author":"Moraes","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.intimp.2016.03.006","article-title":"Gastroprotective effect of 2-mercaptoethanesulfonate against acute gastric mucosal damage induced by ethanol","volume":"34","author":"Amirshahrokhi","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref331","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.intimp.2010.01.008","article-title":"Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma","volume":"10","author":"Lee","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref441","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1055\/s-0032-1312624","article-title":"Stimulatory effect of allantoin on imidazoline I1 receptors in animal and cell line","volume":"44","author":"Yang","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"ref351","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.09.019","article-title":"Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats","volume":"278","author":"Liu","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref191","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4068\/cmj.2014.50.1.6","article-title":"Gastroprotective effects of glutinous rice extract against ethanol, indomethacin, and stress-induced ulcers in rats","volume":"50","author":"Song","year":"2014","journal-title":"Chonnam Med. J."},{"key":"ref391","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1556\/APhysiol.101.2014.4.5","article-title":"Protective effect of ghrelin in a rat model of celiac disease","volume":"101","author":"Nikoukar","year":"2014","journal-title":"Acta Physiol. Hung."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cbi.2009.04.006","article-title":"Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion","volume":"180","author":"Moraes","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2013.11.033","article-title":"Effects of allantoin on cognitive function and hippocampal neurogenesis","volume":"64","author":"Ahn","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12275-017-7089-9","article-title":"N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection","volume":"55","author":"Jang","year":"2017","journal-title":"J. Microbiol."}],"container-title":["Physiology International"],"original-title":[],"link":[{"URL":"https:\/\/www.akademiai.com\/doi\/full-xml\/10.1556\/2060.105.2018.4.30","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/view\/journals\/2060\/105\/4\/article-p325.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/2060.105.2018.4.30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T03:20:31Z","timestamp":1644549631000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/2060.105.2018.4.30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":46,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1556\/2060.105.2018.4.30","relation":{},"ISSN":["2498-602X"],"issn-type":[{"value":"2498-602X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}