{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:18:21Z","timestamp":1648559901107},"reference-count":130,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol. Int."],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:sec sec-type=\"aim\"><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the possible role of heat shock protein-70 (HSP70) induction by 17-allylaminodemethoxygeldanamycin (17-AAG) in collagen-induced arthritis in rats.<\/jats:p><\/jats:sec><jats:sec sec-type=\"material and methods\"><jats:title>Material and methods<\/jats:title><jats:p>Male Wistar rats were divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u200910\/group) and were treated intraperitoneally twice a week for 4 weeks, namely normal control (saline), arthritis control (AR; saline), AR\u2009+\u200917-AAG, AR\u2009+\u2009methotrexate (MTX), and AR\u2009+\u200917-AAG\u2009+\u2009MTX. At the end of the treatments, arthritic score was determined and then the animals were sacrificed. Erythrocyte sedimentation rate (ESR), serum levels of HSP70, interleukin-17 (IL-17), tumor necrosis factor-alpha (TNF-\u03b1), rheumatic factor (RF), C-reactive protein (CRP), malondialdehyde (MDA), glutathione peroxidase (GPx), and matrix metalloproteinase-9 (MMP-9) were determined.<\/jats:p><\/jats:sec><jats:sec sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In the AR group, all parameters increased significantly, except for GPx, which showed a pronounced decrease. The 17-AAG and\/or MTX treatments significantly reduced arthritic score, ESR, IL-17, TNF-\u03b1, RF, CRP, MDA, and MMP-9 with significant increase in GPx compared to the AR group. The HSP70 level was significantly higher in the AR\u2009+\u200917-AAG and the AR\u2009+\u200917-AAG\u2009+\u2009MTX groups but significantly lower in the AR\u2009+\u2009MTX group as compared to the AR group. Also, it was significantly lower in the AR\u2009+\u2009MTX group as compared to the AR\u2009+ 17-AAG group.<\/jats:p><\/jats:sec><jats:sec sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>We concluded that HSP70 induction by 17-AAG attenuated the inflammatory process in a rheumatoid arthritis (RA) model induced by collagen, which suggested that HSP70 inducers can be promising agents in the treatment of RA.<\/jats:p><\/jats:sec>","DOI":"10.1556\/2060.106.2019.17","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T07:51:17Z","timestamp":1562053877000},"page":"128-139","source":"Crossref","is-referenced-by-count":0,"title":["The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats"],"prefix":"10.1556","volume":"106","author":[{"given":"MH","family":"El-Saka","sequence":"first","affiliation":[{"name":"1 Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NM","family":"Madi","sequence":"additional","affiliation":[{"name":"1 Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Shahba","sequence":"additional","affiliation":[{"name":"2 Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref271","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13075-015-0563-z","article-title":"Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis","volume":"17","author":"Kim","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref371","doi-asserted-by":"crossref","first-page":"e000284","DOI":"10.1136\/rmdopen-2016-000284","article-title":"Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice","volume":"3","author":"Miossec","year":"2017","journal-title":"RMD Open"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1098\/rstb.2016.0531","article-title":"Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes","volume":"373","author":"van Eden","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref1291","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12083","article-title":"Basic biology and role of interleukin-17 in immunity and inflammation","volume":"69","author":"Zenobia","year":"2015","journal-title":"Periodontol. 2000"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"e1887","DOI":"10.1038\/cddis.2015.246","article-title":"The interplay between inflammation and metabolism in rheumatoid arthritis","volume":"6","author":"Chimenti","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref1021","doi-asserted-by":"crossref","first-page":"e000284","DOI":"10.1136\/rmdopen-2016-000284","article-title":"Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice","volume":"3","author":"Miossec","year":"2017","journal-title":"RMD Open"},{"key":"ref1161","doi-asserted-by":"crossref","first-page":"6097417","DOI":"10.1155\/2016\/6097417","article-title":"Oxidative stress relevance in the pathogenesis of the rheumatoid arthritis: a systematic review","volume":"2016","author":"Quinonez-Flores","year":"2016","journal-title":"Biomed Res. Int."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.steroids.2010.03.009","article-title":"Effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female Wistar rats","volume":"75","author":"Pantaleao","year":"2010","journal-title":"Steroids"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13578-018-0237-z","article-title":"Heat shock protein 70 protects mouse against post infection irritable bowel syndreome via up regulating intestinal \u03b3\u03b4 T cell\u2019s Th17 response","volume":"8","author":"He","year":"2018","journal-title":"Cell Biosci."},{"key":"ref861","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bcp.2010.11.014","article-title":"Methotrexate induces apoptosis through p53\/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC\/EZH2","volume":"81","author":"Huang","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/09273949709116889","article-title":"Determinations of serum tumor necrosis factor alpha in corneal allografts","volume":"5","author":"Pleyer","year":"1997","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref781","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12192-009-0129-6","article-title":"LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB","volume":"15","author":"Dokladny","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13578-018-0237-z","article-title":"Heat shock protein 70 protects mouse against post infection irritable bowel syndreome via up regulating intestinal \u03b3\u03b4 T cell\u2019s Th17 response","volume":"8","author":"He","year":"2018","journal-title":"Cell Biosci."},{"key":"ref871","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.2174\/13816128113199990507","article-title":"Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases","volume":"19","author":"Ishibashi","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref931","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10787-011-0115-3","article-title":"Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury","volume":"20","author":"Kim","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"978396","DOI":"10.1155\/2012\/978396","article-title":"Markers of treatment response to methotrexate in rheumatoid arthritis: where do we stand?","volume":"2012","author":"Halilova","year":"2012","journal-title":"Int. J. Rheumatol."},{"key":"ref221","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.2174\/13816128113199990507","article-title":"Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases","volume":"19","author":"Ishibashi","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref511","doi-asserted-by":"crossref","first-page":"6097417","DOI":"10.1155\/2016\/6097417","article-title":"Oxidative stress relevance in the pathogenesis of the rheumatoid arthritis: a systematic review","volume":"2016","author":"Quinonez-Flores","year":"2016","journal-title":"Biomed Res. Int."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2047-9158-2-24","article-title":"Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"2","author":"Ho","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"ref481","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/09273949709116889","article-title":"Determinations of serum tumor necrosis factor alpha in corneal allografts","volume":"5","author":"Pleyer","year":"1997","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref301","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00726-010-0689-x","article-title":"Physiology and pathophysiology of matrix metalloproteases","volume":"41","author":"Klein","year":"2011","journal-title":"Amino Acids"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-9255-11-10","article-title":"Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations","volume":"11","author":"Tukaj","year":"2014","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"e0177706","DOI":"10.1371\/journal.pone.0177706","article-title":"The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells","volume":"12","author":"Schaefer","year":"2017","journal-title":"PLoS One"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"978396","DOI":"10.1155\/2012\/978396","article-title":"Markers of treatment response to methotrexate in rheumatoid arthritis: where do we stand?","volume":"2012","author":"Halilova","year":"2012","journal-title":"Int. J. Rheumatol."},{"key":"ref291","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neuroscience.2014.11.010","article-title":"Pharmacological induction of the 70-kDa heat shock protein protects against brain injury","volume":"284","author":"Kim","year":"2015","journal-title":"Neuroscience"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"7509653","DOI":"10.1155\/2016\/7509653","article-title":"Effect of N-feruloylserotonin and methotrexate on severity of experimental arthritis and on messenger RNA expression of key proinflammatory markers in liver","volume":"2016","author":"Paskova","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref1181","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3892\/mmr.2014.2804","article-title":"Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis","volume":"11","author":"Shen","year":"2015","journal-title":"Mol. Med. 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Med."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10753-014-0002-3","article-title":"Pemetrexed ameliorates experimental arthritis in rats","volume":"38","author":"Karatas","year":"2015","journal-title":"Inflammation"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"26239","DOI":"10.1038\/srep26239","article-title":"CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage","volume":"6","author":"Chang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref231","doi-asserted-by":"crossref","first-page":"870628","DOI":"10.1155\/2013\/870628","article-title":"Expression of glutathione peroxidase and glutathione reductase and level of free radical processes under toxic hepatitis in rats","volume":"2013","author":"Iskusnykh","year":"2013","journal-title":"J. Toxicol."},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s00296-011-1867-1","article-title":"Methotrexate attenuates the Th17\/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients","volume":"32","author":"Li","year":"2012","journal-title":"Rheumatol. Int."},{"key":"ref691","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11064-007-9453-3","article-title":"Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias","volume":"33","author":"Casado","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref381","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12192-015-0578-z","article-title":"Analysis of serum heat shock protein 70 (HSPA1A) concentrations for diagnosis and disease activity monitoring in patients with rheumatoid arthritis","volume":"20","author":"Najafizadeh","year":"2015","journal-title":"Cell Stress Chaperones."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"e1887","DOI":"10.1038\/cddis.2015.246","article-title":"The interplay between inflammation and metabolism in rheumatoid arthritis","volume":"6","author":"Chimenti","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref891","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.rmed.2003.08.014","article-title":"Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment","volume":"98","author":"Jumper","year":"2004","journal-title":"Respir. Med."},{"key":"ref471","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1309\/QB1G-6FRR-DNWX-BKQ9","article-title":"Erythrocyte sedimentation rate: use of fresh blood for quality control","volume":"117","author":"Plebani","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunology"},{"key":"ref1121","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1309\/QB1G-6FRR-DNWX-BKQ9","article-title":"Erythrocyte sedimentation rate: use of fresh blood for quality control","volume":"117","author":"Plebani","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.4049\/jimmunol.1200593","article-title":"Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells","volume":"190","author":"Bae","year":"2013","journal-title":"J. Immunol."},{"key":"ref281","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10787-011-0115-3","article-title":"Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury","volume":"20","author":"Kim","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1349-7006.2008.00809.x","article-title":"Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70","volume":"99","author":"Chakraborty","year":"2008","journal-title":"Cancer Sci."},{"key":"ref791","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-3-319-11731-7_12","article-title":"The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease","volume":"78","author":"Duncan","year":"2015","journal-title":"Subcell. Biochem."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/OARRR.S131668","article-title":"Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis","volume":"9","author":"Bello","year":"2017","journal-title":"Open Access Rheumatol."},{"key":"ref751","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref941","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neuroscience.2014.11.010","article-title":"Pharmacological induction of the 70-kDa heat shock protein protects against brain injury","volume":"284","author":"Kim","year":"2015","journal-title":"Neuroscience"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.3892\/etm.2016.3821","article-title":"Hsp70 inducer, 17-allylamino-demethoxygeldanamycin, provides neuroprotection via anti-inflammatory effects in a rat model of traumatic brain injury","volume":"12","author":"Gu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref721","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200702-291OC","article-title":"Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis","volume":"176","author":"Chatterjee","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref801","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hcl.2010.09.006","article-title":"Historical perspective on the etiology of rheumatoid arthritis","volume":"27","author":"Entezami","year":"2011","journal-title":"Hand Clin."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunology"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2012.00095","article-title":"The anti-inflammatory mechanisms of Hsp70","volume":"3","author":"Borges","year":"2012","journal-title":"Front. Immunol."},{"key":"ref331","first-page":"390","article-title":"Systemic therapy of psoriasis: methotrexate","volume":"112","author":"Kozub","year":"2011","journal-title":"Bratisl. Lek. Listy."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-3-319-11731-7_12","article-title":"The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease","volume":"78","author":"Duncan","year":"2015","journal-title":"Subcell. Biochem."},{"key":"ref851","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2047-9158-2-24","article-title":"Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"2","author":"Ho","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"ref661","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.4049\/jimmunol.1200593","article-title":"Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells","volume":"190","author":"Bae","year":"2013","journal-title":"J. Immunol."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4103\/0378-6323.120723","article-title":"Estimation of serum level of interleukin-17 and interleukin-4 in leprosy, towards more understanding of leprosy immunopathogenesis","volume":"79","author":"Abdallah","year":"2013","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"26239","DOI":"10.1038\/srep26239","article-title":"CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage","volume":"6","author":"Chang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref671","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/OARRR.S131668","article-title":"Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis","volume":"9","author":"Bello","year":"2017","journal-title":"Open Access Rheumatol."},{"key":"ref1241","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-9255-11-10","article-title":"Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations","volume":"11","author":"Tukaj","year":"2014","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref901","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10753-014-0002-3","article-title":"Pemetrexed ameliorates experimental arthritis in rats","volume":"38","author":"Karatas","year":"2015","journal-title":"Inflammation"},{"key":"ref1201","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/rheumatology\/kew266","article-title":"Heat shock proteins and their immunomodulatory role in inflammatory arthritis","volume":"56","author":"Spierings","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00726-010-0689-x","article-title":"Physiology and pathophysiology of matrix metalloproteases","volume":"41","author":"Klein","year":"2011","journal-title":"Amino Acids"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"870628","DOI":"10.1155\/2013\/870628","article-title":"Expression of glutathione peroxidase and glutathione reductase and level of free radical processes under toxic hepatitis in rats","volume":"2013","author":"Iskusnykh","year":"2013","journal-title":"J. Toxicol."},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/jphp.12752","article-title":"Daily oral administration of low-dose methotrexate has greater antirheumatic effects in collagen-induced arthritis rats","volume":"69","author":"Koyama","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref391","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jim.2005.08.012","article-title":"Comparison of two ELISAs for the determination of Hsp70 in serum","volume":"306","author":"Njemini","year":"2005","journal-title":"J. Immunol. Methods."},{"key":"ref1141","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1096\/fj.06-7637com","article-title":"Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis","volume":"21","author":"Poulaki","year":"2007","journal-title":"FASEB J."},{"key":"ref731","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget."},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"E1911","DOI":"10.3390\/molecules22111911","article-title":"Ferulaldehyde improves the effect of methotrexate in experimental arthritis","volume":"22","author":"Slovak","year":"2017","journal-title":"Molecules"},{"key":"ref121","first-page":"959","article-title":"Oxidative stress and enzymatic antioxidant status in rheumatoid arthritis: a case control study","volume":"14","author":"Desai","year":"2010","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref961","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5114\/reum.2015.55825","article-title":"Correlation between erythrocyte sedimentation rate and C-reactive protein level in patients with rheumatic diseases","volume":"53","author":"Kotulska","year":"2015","journal-title":"Reumatologia"},{"key":"ref771","first-page":"959","article-title":"Oxidative stress and enzymatic antioxidant status in rheumatoid arthritis: a case control study","volume":"14","author":"Desai","year":"2010","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1349-7006.2008.00809.x","article-title":"Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70","volume":"99","author":"Chakraborty","year":"2008","journal-title":"Cancer Sci."},{"key":"ref171","first-page":"293","article-title":"Cancer chemotherapy: targeting folic acid synthesis","volume":"2","author":"Hagner","year":"2010","journal-title":"Cancer Manag. Res."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11064-007-9453-3","article-title":"Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias","volume":"33","author":"Casado","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref991","doi-asserted-by":"crossref","first-page":"3908061","DOI":"10.1155\/2017\/3908061","article-title":"The role of IL-17 and related cytokines in inflammatory autoimmune diseases","volume":"2017","author":"Kuwabara","year":"2017","journal-title":"Mediators Inflamm."},{"key":"ref111","first-page":"55","article-title":"Isolation and characterization of C-reactive protein and serum amyloid P component in the rat","volume":"45","author":"de Beer","year":"1982","journal-title":"Immunology"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref361","doi-asserted-by":"crossref","first-page":"e0152925","DOI":"10.1371\/journal.pone.0152925","article-title":"Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis","volume":"11","author":"Mateen","year":"2016","journal-title":"PLoS One"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13075-015-0563-z","article-title":"Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis","volume":"17","author":"Kim","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref1081","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.steroids.2010.03.009","article-title":"Effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female Wistar rats","volume":"75","author":"Pantaleao","year":"2010","journal-title":"Steroids"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/rheumatology\/kew266","article-title":"Heat shock proteins and their immunomodulatory role in inflammatory arthritis","volume":"56","author":"Spierings","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"ref1051","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"NF-\u03baB: roles and regulation in different CD4(+) T-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref531","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3892\/mmr.2014.2804","article-title":"Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis","volume":"11","author":"Shen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref811","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.3892\/etm.2016.3821","article-title":"Hsp70 inducer, 17-allylamino-demethoxygeldanamycin, provides neuroprotection via anti-inflammatory effects in a rat model of traumatic brain injury","volume":"12","author":"Gu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2012.00095","article-title":"The anti-inflammatory mechanisms of Hsp70","volume":"3","author":"Borges","year":"2012","journal-title":"Front. Immunol."},{"key":"ref631","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.1401810","article-title":"IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation","volume":"194","author":"Ye","year":"2015","journal-title":"J. Immunol."},{"key":"ref1111","first-page":"S-23","article-title":"An evidence-based approach to laboratory tests in usual care of patients with rheumatoid arthritis","volume":"32","author":"Pincus","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref461","first-page":"S-23","article-title":"An evidence-based approach to laboratory tests in usual care of patients with rheumatoid arthritis","volume":"32","author":"Pincus","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref501","first-page":"1826","article-title":"Heat shock protein 90 inhibition by 17-dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke","volume":"7","author":"Qi","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200702-291OC","article-title":"Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis","volume":"176","author":"Chatterjee","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref621","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/art.27344","article-title":"A novel heat-shock protein co-inducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis","volume":"62","author":"Wieten","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref761","first-page":"55","article-title":"Isolation and characterization of C-reactive protein and serum amyloid P component in the rat","volume":"45","author":"de Beer","year":"1982","journal-title":"Immunology"},{"key":"ref1151","first-page":"1826","article-title":"Heat shock protein 90 inhibition by 17-dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke","volume":"7","author":"Qi","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"ref641","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12083","article-title":"Basic biology and role of interleukin-17 in immunity and inflammation","volume":"69","author":"Zenobia","year":"2015","journal-title":"Periodontol. 2000"},{"key":"ref1061","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0009-8981(90)90159-P","article-title":"Quantitative determination of IgM-rheumatoid factor by enzyme immunoassay-standardization using a serum from a rheumatoid arthritis patient","volume":"188","author":"Oka","year":"1990","journal-title":"Clin. Chim. Acta."},{"key":"ref601","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1158\/1078-0432.CCR-10-0503","article-title":"Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin","volume":"16","author":"Vaishampayan","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12192-015-0578-z","article-title":"Analysis of serum heat shock protein 70 (HSPA1A) concentrations for diagnosis and disease activity monitoring in patients with rheumatoid arthritis","volume":"20","author":"Najafizadeh","year":"2015","journal-title":"Cell Stress Chaperones."},{"key":"ref351","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s00296-011-1867-1","article-title":"Methotrexate attenuates the Th17\/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients","volume":"32","author":"Li","year":"2012","journal-title":"Rheumatol. Int."},{"key":"ref981","first-page":"390","article-title":"Systemic therapy of psoriasis: methotrexate","volume":"112","author":"Kozub","year":"2011","journal-title":"Bratisl. Lek. Listy."},{"key":"ref151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hcl.2010.09.006","article-title":"Historical perspective on the etiology of rheumatoid arthritis","volume":"27","author":"Entezami","year":"2011","journal-title":"Hand Clin."},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.1401810","article-title":"IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation","volume":"194","author":"Ye","year":"2015","journal-title":"J. Immunol."},{"key":"ref261","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yjmcc.2014.03.008","article-title":"The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis","volume":"72","author":"Kim","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/rheumatology\/keu279","article-title":"Methotrexate-mediated inhibition of nuclear factor \u03baB activation by distinct pathways in T cells and fibroblast-like synoviocytes","volume":"54","author":"Spurlock","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"e0177706","DOI":"10.1371\/journal.pone.0177706","article-title":"The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells","volume":"12","author":"Schaefer","year":"2017","journal-title":"PLoS One"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"3908061","DOI":"10.1155\/2017\/3908061","article-title":"The role of IL-17 and related cytokines in inflammatory autoimmune diseases","volume":"2017","author":"Kuwabara","year":"2017","journal-title":"Mediators Inflamm."},{"key":"ref441","doi-asserted-by":"crossref","first-page":"7509653","DOI":"10.1155\/2016\/7509653","article-title":"Effect of N-feruloylserotonin and methotrexate on severity of experimental arthritis and on messenger RNA expression of key proinflammatory markers in liver","volume":"2016","author":"Paskova","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref541","doi-asserted-by":"crossref","first-page":"E1911","DOI":"10.3390\/molecules22111911","article-title":"Ferulaldehyde improves the effect of methotrexate in experimental arthritis","volume":"22","author":"Slovak","year":"2017","journal-title":"Molecules"},{"key":"ref1271","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/art.27344","article-title":"A novel heat-shock protein co-inducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis","volume":"62","author":"Wieten","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref411","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0009-8981(90)90159-P","article-title":"Quantitative determination of IgM-rheumatoid factor by enzyme immunoassay-standardization using a serum from a rheumatoid arthritis patient","volume":"188","author":"Oka","year":"1990","journal-title":"Clin. Chim. Acta."},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"e0152925","DOI":"10.1371\/journal.pone.0152925","article-title":"Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis","volume":"11","author":"Mateen","year":"2016","journal-title":"PLoS One"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"NF-\u03baB: roles and regulation in different CD4(+) T-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1038\/sj.onc.1210978","article-title":"Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1","volume":"27","author":"Sugimoto","year":"2008","journal-title":"Oncogene"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1098\/rstb.2016.0531","article-title":"Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes","volume":"373","author":"van Eden","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref1251","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1158\/1078-0432.CCR-10-0503","article-title":"Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin","volume":"16","author":"Vaishampayan","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref491","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1096\/fj.06-7637com","article-title":"Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis","volume":"21","author":"Poulaki","year":"2007","journal-title":"FASEB J."},{"key":"ref571","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/rheumatology\/keu279","article-title":"Methotrexate-mediated inhibition of nuclear factor \u03baB activation by distinct pathways in T cells and fibroblast-like synoviocytes","volume":"54","author":"Spurlock","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4103\/0378-6323.120723","article-title":"Estimation of serum level of interleukin-17 and interleukin-4 in leprosy, towards more understanding of leprosy immunopathogenesis","volume":"79","author":"Abdallah","year":"2013","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref101","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref821","first-page":"293","article-title":"Cancer chemotherapy: targeting folic acid synthesis","volume":"2","author":"Hagner","year":"2010","journal-title":"Cancer Manag. Res."},{"key":"ref911","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yjmcc.2014.03.008","article-title":"The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis","volume":"72","author":"Kim","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref1041","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jim.2005.08.012","article-title":"Comparison of two ELISAs for the determination of Hsp70 in serum","volume":"306","author":"Njemini","year":"2005","journal-title":"J. Immunol. Methods."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bcp.2010.11.014","article-title":"Methotrexate induces apoptosis through p53\/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC\/EZH2","volume":"81","author":"Huang","year":"2011","journal-title":"Biochem. 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