{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:05:45Z","timestamp":1789574745281,"version":"build-2803163510"},"reference-count":84,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Physiol. Int."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Betanin is a betacyanin with antioxidant and anti-inflammatory activities whose effects were investigated in a nonalcoholic steatohepatitis (NASH) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main methods<\/jats:title>\n                    <jats:p>\n                      Ninety-six male naval medical research institute (NMRI) mice were divided into eight groups (\n                      <jats:italic>n<\/jats:italic>\n                      = 12) including normal control, high fat diet (HFD), Sham, and positive control treated with\n                      <jats:italic>trans<\/jats:italic>\n                      -chalcone. Three experimental groups were treated with 5 mg\/kg, 10 mg\/kg or 20 mg\/kg betanin, and a betanin protective group was also defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four weeks of HFD treatment resulted in steatohepatitis with associated fibrosis. Significant increase was observed in serum levels of triglycerides (TG), total cholesterol (TC), glucose, insulin, leptin, liver enzymes, malondialdehyde (MDA), furthermore insulin resistance and (sterol regulatory element-binding protein-1c) SREBP-1c were detected. Levels of high-density lipoprotein cholesterol (HDL-C), adiponectin, superoxide dismutase (SOD), catalase (CAT), and PPAR-\u03b1 (peroxisome proliferator-activated receptor-\u03b1) considerably decreased. Treatment by betanin, particularly the 20 mg\/kg dosage, attenuated these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Betanin is a potential treating agent of steatohepatitis and works through up-regulation of PPAR-\u03b1, down-regulation of SREBP-1c, modification of adipokine levels and modulation of lipid profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/2060.2020.00001","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T09:22:37Z","timestamp":1586856157000},"page":"67-81","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":19,"title":["Betanin effect on PPAR-\u03b1 and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis"],"prefix":"10.1556","volume":"107","author":[{"given":"L.","family":"Yahaghi","sequence":"first","affiliation":[{"name":"1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehreh","family":"Yaghmaei","sequence":"additional","affiliation":[{"name":"1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hayati-Roodbari","sequence":"additional","affiliation":[{"name":"1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Irani","sequence":"additional","affiliation":[{"name":"1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ebrahim-Habibi","sequence":"additional","affiliation":[{"name":"2Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"3Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref281","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021041","article-title":"The definition of insulin resistance using HOMA-IR for Americans of Mexican descent using machine learning","volume":"6","author":"Qu","year":"2011","journal-title":"PLoS One"},{"key":"ref601","first-page":"351","article-title":"Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease","volume":"20","author":"Kohjima","year":"2007","journal-title":"Int J Mol 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