{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:57:52Z","timestamp":1775087872128,"version":"3.50.1"},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["PhysInt"],"published-print":{"date-parts":[[2022,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:sec>\n               <jats:title>Background and Aims<\/jats:title>\n               <jats:p>Endogenous gaseous substances, such as NO and CO have been found to be effective vasodilators earlier. H<jats:sub>2<\/jats:sub>S has been identified as an additional one, however, for that substance both vasodilatory and vasoconstrictor responses have been described in different vascular territories. Our aim was to examine the effect of hydrogen sulfide on the tone of cerebral arterioles and some aspects of its mechanism.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>The work was performed on excised rat anterior cerebral artery segments in vitro (diameter range 150\u2013250\u2009\u00b5m), using a pressure myograph system. We used NaHS as exogenous H<jats:sub>2<\/jats:sub>S donor, propargylglycine (PAG) to abolish the endogenous synthesis of hydrogen sulfide and 4,4\u2032-Diisothiocyanatostilbene-2,2\u2032-disulfonic acid (DIDS) to examine the potential role of Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub>\n                  <jats:sup>-<\/jats:sup> exchanger in the effects of H<jats:sub>2<\/jats:sub>S. The time course of the events after application of exogenous H<jats:sub>2<\/jats:sub>S was also evaluated.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Our findings revealed that in these pathologically important vessels <jats:italic>(1)<\/jats:italic> endogenously produced H<jats:sub>2<\/jats:sub>S is not a vasodilator, but a moderate vasoconstrictor; <jats:italic>(2)<\/jats:italic> H<jats:sub>2<\/jats:sub>S has a biphasic effect: low concentrations are moderate vasoconstrictors, while at higher concentrations the initial contraction is followed by dilatation; <jats:italic>(3)<\/jats:italic> that vasodilation is prevented by DIDS (4,4\u2032-Diisothiocyanatostilbene-2,2\u2032-disulfonic acid disodium, an inhibitor of the Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub>\n                  <jats:sup>-<\/jats:sup> exchanger).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>These studies confirm that H<jats:sub>2<\/jats:sub>S should be taken into consideration as a modulator of cerebral arteriolar tone in mammals.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1556\/2060.2022.00190","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T18:36:22Z","timestamp":1646073382000},"page":"70-77","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["The effect of hydrogen sulfide on the contractility of cerebral arterioles. A pilot study"],"prefix":"10.1556","volume":"109","author":[{"given":"Eleni","family":"Dong\u00f3","sequence":"first","affiliation":[{"name":"Department of Physiology, Semmelweis University, Budapest, Hungary"},{"name":"Department of Neurology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Harasztos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-2391","authenticated-orcid":true,"given":"Gy\u00f6rgy L.","family":"N\u00e1dasy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Physiology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref101","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.lfs.2008.08.006","article-title":"Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition","volume":"83","author":"Kiss","year":"2008","journal-title":"Life Sci"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"C1261","DOI":"10.1152\/ajpcell.00195.2008","article-title":"Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells","volume":"295","author":"Lim","year":"2008","journal-title":"Am J Physiol Cell 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Pharmacol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuint.2019.01.027","article-title":"Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system","volume":"126","author":"Kimura","year":"2019","journal-title":"Neurochem Int"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2017.10.010","article-title":"The mechanism of action and role of hydrogen sulfide in the control of vascular tone","volume":"81","author":"Dongo","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuroscience.2012.12.057","article-title":"L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS\/H(2)S pathway","volume":"237","author":"Wang","year":"2013","journal-title":"Neuroscience"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuint.2019.01.027","article-title":"Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system","volume":"126","author":"Kimura","year":"2019","journal-title":"Neurochem Int"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1139\/y03-077","article-title":"Modulation of endogenous production of H2S in rat tissues","volume":"81","author":"Zhao","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol 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of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat Commun"}],"container-title":["Physiology 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