{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:40:05Z","timestamp":1750434005449,"version":"3.41.0"},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["PhysInt"],"published-print":{"date-parts":[[2025,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gestational diabetes mellitus (GDM) is an endocrine\u2013metabolic disorder that develops during pregnancy. Glucose transporters (GLUTs), which facilitate the transport of glucose across the plasma membrane (facilitated diffusion) play a key role in the progression of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to analyze the general characteristics and expression of GLUTs in GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review was performed following the PRISMA guidelines. A literature search was performed without language restrictions using the PubMed, Web of Science, Redalyc, Google Scholar, Cochrane, and Scopus databases between 2010 and 2023 using the keywords GLUT, Gestational diabetes mellitus, GDM and GLUT, Glucose metabolism and GLUT, Glucose receptors to identify most human studies, as the majorityof studies use murine models, focusing on a positive diagnosis of GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 36 articles were included in this review. Of the 36 articles, 21 described the general characteristics of GLUTs, and 15 were scientific reports (12 in humans and 3\u00a0in animals). The studies showed that interleukin-2, tumor necrosis factor-\u03b1, and leptin correlated negatively with the expression of GLUT1 in patients with GDM. The three murine studies showed that hyperglycemia was associated with decreased GLUT2 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence of GLUT expression at the gestational\u00a0stage provides a better understanding of fetal life conditions and how they contribute to the\u00a0development of GDM. Therefore, analyzing GLUT expression serves as a preventive measure.<\/jats:p><\/jats:sec>","DOI":"10.1556\/2060.2025.00347","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T16:53:10Z","timestamp":1747241590000},"page":"101-117","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Overview and expression of GLUT in gestational diabetes mellitus: A literature review"],"prefix":"10.1556","volume":"112","author":[{"given":"Betsy Corina","family":"Sosa Garcia","sequence":"first","affiliation":[{"name":"Council of Science and Technology of the State of Mexico (COMECYT), 50120, Toluca, Mexico"},{"name":"Autonomous University of the State of Mexico, 50010, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Berenice","family":"Lucero Orozco","sequence":"additional","affiliation":[{"name":"Metropolitan Autonomous University, Iztapalapa Unit, 09310 Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Arriaga","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Autonomous University of the State of Mexico, 50010, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Yahir","family":"Vargas Zagal","sequence":"additional","affiliation":[{"name":"Autonomous University of the State of Mexico, 50010, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Guti\u00e9rrez","family":"Lezama","sequence":"additional","affiliation":[{"name":"Autonomous University of the State of Mexico, 50010, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-8950","authenticated-orcid":true,"given":"Hugo","family":"Mendieta Zer\u00f3n","sequence":"additional","affiliation":[{"name":"Autonomous University of the State of Mexico, 50010, Toluca, Mexico"},{"name":"Maternal Perinatal Hospital \u201cM\u00f3nica Pretelini Saenz\u201d, 50010, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"issue":"1","key":"B1","series-title":"Med Interna M\u00e9x","first-page":"91","article-title":"Gestational diabetes. 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