{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:48:19Z","timestamp":1792183699072,"version":"4.4.0"},"reference-count":35,"publisher":"Akademiai Kiado Zrt.","issue":"2","funder":[{"name":"Xilingol League Technology Plan project","award":["202217"],"award-info":[{"award-number":["202217"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["PhysInt"],"published-print":{"date-parts":[[2025,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adipose-derived stem cell (ADSC) derived exosomes have been widely studied in disease treatment. Exosomes are able to deliver bioactive molecules, including non-coding RNAs and proteins. Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides and are enriched in exosomes. This work aimed to explore the effects of lncRNA KLF3 antisense RNA 1 (KLF3-AS1) that delivered by ADSC-derived exosomes on ovarian aging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ADSCs were isolated and characterized with the surface biomarkers. Exosomes were isolated from ADSCs. The biomarkers of ADSC-derived exosomes were identified using western blotting. Exosomes were labeled with PKH26 and internalized by primary granulosa cells (pGCs), and relative images were taken under fluorescence microscope. ADSCs were transfected with KLF3-AS1, and exosomes were isolated for treatment of aging female mice. The ovary weight was recorded. The follicular development was measured by Hematoxylin and eosin (H&amp;E) staining and Masson's trichrome staining. Apoptosis of ovary tissues was detected by TUNEL assay. The senescence and apoptosis of pGCs were determined by S-\u03b2-gal staining kit and Annexin V\/PI detection kit. RNA pulldown and RNA Immunoprecipitation Chip (RIP) assay were performed to determine the interaction of Y box binding protein 1 (YBX1) with KLF3-AS1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ADSC-derived exosomes could deliver KLF3-AS1 to pGCs. Treatment with ADSC-derived exosomes notably elevated the ovary weight and enhanced follicular development in aged mice, whereas depletion of KLF3-AS1 reversed these effects and promoted cell apoptosis. ADSCs-derived exosomes alleviated senescence and apoptosis of pGCs, while KLF3-AS1 depletion blocked these phenotypes. KLF3-AS1 directly interacts with YBX1. KLF3-AS1 depletion inhibited phosphorylation of PI3K, Akt, and mTOR in pGC, and overexpression of YBX1 reversed these phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADSC-derived exosomal KLF3-AS1 could improve ovary aging and enhance pGC viability via targeting the YBX1 and PI3K\/AKT\/mTOR signaling.<\/jats:p><\/jats:sec>","DOI":"10.1556\/2060.2025.00357","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:21:17Z","timestamp":1744356077000},"page":"171-186","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Adipose-derived stem cells exosomal KLF3-AS1 attenuates ovarian function by YBX1\/PI3K\/Akt\/mTOR signaling"],"prefix":"10.1556","volume":"112","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Reproductive Center, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"},{"name":"The Obstetric and Gynecologic Ward 2, Grand Hospital of Shuozhou, Shanxi Shuozhou, 036000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department Elderly Medicine Hohhot First Hospital, Inner Mongolia Hohhot, 010000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Center, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhu","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Reproductive Center, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Science and Education Section, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9337-5989","authenticated-orcid":true,"given":"Hongwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0105-1857","authenticated-orcid":true,"given":"Caisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xilingol League Central Hospital, Inner Mongolia Xilingol League, 026000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"3","key":"B1","series-title":"Int J Mol Sci","article-title":"Importance of melatonin in assisted reproductive technology and ovarian aging","volume":"21","author":"Tamura","year":"2020","unstructured":"Tamura, Jozaki, Tanabe, Shirafuta, Mihara, Shinagawa, et\u00a0al. Importance of melatonin in assisted reproductive technology and ovarian aging. Int J Mol Sci 2020; 21(3)."},{"issue":"2","key":"B2","series-title":"Reproduction","first-page":"R19","article-title":"Berkowitz Mechanisms of ovarian aging","volume":"162","author":"Park","year":"2021","unstructured":"Park, Walsh. Berkowitz Mechanisms of ovarian aging. Reproduction 2021; 162(2): R19\u2013r33."},{"issue":"3","key":"B3","series-title":"Int J Mol Sci","article-title":"Mendoza-Tesarik ovarian aging: molecular mechanisms and medical management","volume":"22","author":"Tesarik","year":"2021","unstructured":"Tesarik, Gal\u00e1n-L\u00e1zaro. Mendoza-Tesarik ovarian aging: molecular mechanisms and medical management. Int J Mol Sci 2021; 22(3)."},{"key":"B4","series-title":"Ageing Res Rev","article-title":"Mitochondria in ovarian aging and reproductive longevity","volume":"63","author":"Chiang","year":"2020","unstructured":"Chiang, Shukla, Pagidas, Ahmed, Karri, Gunn, et\u00a0al. Mitochondria in ovarian aging and reproductive longevity. Ageing Res Rev 2020; 63: 101168."},{"issue":"12","key":"B5","series-title":"J Cell Physiol","first-page":"7966","article-title":"Oxidative stress in oocyte aging and female reproduction","volume":"236","author":"Wang","year":"2021","unstructured":"Wang, Tang, Wang, Tan, Song, Zhou, et\u00a0al. Oxidative stress in oocyte aging and female reproduction. J Cell Physiol 2021; 236(12): 7966\u20137983."},{"issue":"11","key":"B6","series-title":"Sci China Life Sci","first-page":"2301","article-title":"Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction","volume":"65","author":"Zhou","year":"2022","unstructured":"Zhou, Deng, Yang, Cao, Zhao, Liu, et\u00a0al. Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction. Sci China Life Sci 2022; 65(11): 2301\u20132315."},{"key":"B7","series-title":"Reprod Biol Endocrinol","first-page":"28","article-title":"Sharma Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","unstructured":"Agarwal, Gupta. Sharma Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28."},{"issue":"6","key":"B8","series-title":"Aging (Albany NY)","first-page":"4918","article-title":"Efficacy and safety of recombinant human follicle-stimulating hormone in patients undergoing in vitro fertilization-embryo transfer","volume":"12","author":"Hu","year":"2020","unstructured":"Hu, Zhang, Quan, Lv, Qian, Huang, et\u00a0al. Efficacy and safety of recombinant human follicle-stimulating hormone in patients undergoing in vitro fertilization-embryo transfer. Aging (Albany NY) 2020; 12(6): 4918\u20134930."},{"issue":"4","key":"B9","series-title":"Biotechnol Adv","first-page":"1111","article-title":"Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review","volume":"36","author":"Bacakova","year":"2018","unstructured":"Bacakova, Zarubova, Travnickova, Musilkova, Pajorova, Slepicka, et\u00a0al. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review. Biotechnol Adv 2018; 36(4): 1111\u20131126."},{"issue":"4","key":"B10","series-title":"Int J Mol Sci","article-title":"Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing","volume":"21","author":"Mazini","year":"2020","unstructured":"Mazini, Rochette, Admou, Amal, Malka. Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing. 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Oxidative Med Cell longevity 2019; 2019."},{"issue":"3","key":"B35","series-title":"Cell Cycle","first-page":"289","article-title":"Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis","volume":"21","author":"Wen","year":"2022","unstructured":"Wen, Lin, Zou, Lin, Liu. Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis. 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