{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:25:25Z","timestamp":1793381125787,"version":"4.5.0"},"reference-count":20,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["PhysInt"],"published-print":{"date-parts":[[2025,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our study evaluated the predictive value of Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI), as well as their combined assessment, for predicting the risk of postoperative complication in gastric cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively collected and analyzed data from elderly gastric cancer patients who underwent gastrectomy from 2013 to 2016. Preoperative measurements, GNRI and SII, were taken for each patient within seven days before surgery. The severity of postoperative\u00a0complications was evaluated. There were 280 patients who met the criteria, including 187 patients without postoperative complications and 93 patients with postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>It was observed that patients with postoperative complications had significantly higher preoperative SII indices and significantly lower GNRI indices. In addition, in terms of the severity of complications, as the severity of complications increases, there is a notable increase in the SII index and a marked decrease in the GNRI index. Combined assessment of SII and GNRI significantly improved the sensitivity and specificity compared with either index alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The concurrent assessment of preoperative SII and GNRI appears to be a valuable tool for predicting long-term prognosis in elderly gastric cancer patients undergoing curative resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/2060.2025.00690","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:18:48Z","timestamp":1764069528000},"page":"445-455","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Predictive values of preoperative geriatric nutritional risk index and systemic immune-inflammation index for postoperative complications and 5-year overall survival after curative resection in elderly gastric cancer patients"],"prefix":"10.1556","volume":"112","author":[{"given":"Zhijuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Jiangnan University Medical Center, Wuxi 214000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Jiangnan University Medical Center, Wuxi 214000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7865-6806","authenticated-orcid":true,"given":"Yingwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Jiangnan University Medical Center, Wuxi 214000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"18","key":"B1","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.3390\/ijms21186586","article-title":"The crosstalk between microbiome and immune response in gastric cancer","volume":"21","author":"Nasr R","year":"2020","unstructured":"Nasr R, Shamseddine A, Mukherji D, Nassar F, Temraz S. The crosstalk between microbiome and immune response in gastric cancer. Int J Mol Sci 2020; 21(18): 6586. 10.3390\/ijms21186586https:\/\/doi.org\/10.3390\/ijms21186586"},{"issue":"10-12","key":"B2","series-title":"Inflamm Res","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00011-021-01501-x","article-title":"Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer","volume":"70","author":"Yang H","year":"2021","unstructured":"Yang H, Wei B, Hu B. Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer. Inflamm Res 2021; 70(10-12): 1015\u201326. 10.1007\/s00011-021-01501-xhttps:\/\/doi.org\/10.1007\/s00011-021-01501-x"},{"issue":"11","key":"B3","series-title":"Yonsei Med J","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3349\/ymj.2022.0273","article-title":"Impact of cardiovascular diseases on mortality in gastric cancer patients with preexisting chronic disease","volume":"63","author":"Han KT","year":"2022","unstructured":"Han KT, Kim DW, Kim W. Impact of cardiovascular diseases on mortality in gastric cancer patients with preexisting chronic disease. Yonsei Med J 2022; 63(11): 1043\u20139. 10.3349\/ymj.2022.0273https:\/\/doi.org\/10.3349\/ymj.2022.0273"},{"issue":"3","key":"B4","series-title":"J Epidemiol","doi-asserted-by":"publisher","first-page":"110","DOI":"10.2188\/jea.JE20170241","article-title":"Impact of comorbidities on survival in gastric, colorectal, and lung cancer patients","volume":"29","author":"Morishima T","year":"2019","unstructured":"Morishima T, Matsumoto Y, Koeda N, Shimada H, Maruhama T, Matsuki D, et\u00a0al. Impact of comorbidities on survival in gastric, colorectal, and lung cancer patients. J Epidemiol 2019; 29(3): 110\u20135. 10.2188\/jea.JE20170241https:\/\/doi.org\/10.2188\/jea.JE20170241"},{"issue":"8","key":"B5","series-title":"Eur J Surg Oncol","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.ejso.2010.05.023","article-title":"Gastric cancer in the elderly: an overview","volume":"36","author":"Saif MW","year":"2010","unstructured":"Saif MW, Makrilia N, Zalonis A, Merikas M, Syrigos K. Gastric cancer in the elderly: an overview. Eur J Surg Oncol 2010; 36(8): 709\u201317. 10.1016\/j.ejso.2010.05.023https:\/\/doi.org\/10.1016\/j.ejso.2010.05.023"},{"issue":"5","key":"B6","series-title":"Clin Nutr","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/s0261-5614(98)80022-8","article-title":"The impact of malnutrition on the quality of life in the elderly","volume":"18","author":"Vetta F","year":"1999","unstructured":"Vetta F, Ronzoni S, Taglieri G, Bollea MR. The impact of malnutrition on the quality of life in the elderly. Clin Nutr 1999; 18(5): 259\u201367. 10.1016\/s0261-5614(98)80022-8https:\/\/doi.org\/10.1016\/s0261-5614(98)80022-8"},{"key":"B7","series-title":"Clin Interv Aging","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2147\/CIA.S140859","article-title":"Assessing the nutritional status of hospitalized elderly","volume":"12","author":"Abd Aziz NAS","year":"2017","unstructured":"Abd Aziz NAS, Teng N, Abdul Hamid MR, Ismail NH. Assessing the nutritional status of hospitalized elderly. Clin Interv Aging 2017; 12: 1615\u201325. 10.2147\/CIA.S140859https:\/\/doi.org\/10.2147\/CIA.S140859"},{"issue":"7203","key":"B8","series-title":"Nature","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani A","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454(7203): 436\u201344. 10.1038\/nature07205https:\/\/doi.org\/10.1038\/nature07205"},{"issue":"4","key":"B9","series-title":"Am J Clin Nutr","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients","volume":"82","author":"Bouillanne O","year":"2005","unstructured":"Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, et\u00a0al. Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 2005; 82(4): 777\u201383. 10.1093\/ajcn\/82.4.777https:\/\/doi.org\/10.1093\/ajcn\/82.4.777"},{"issue":"34","key":"B10","series-title":"World J Gastroenterol","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.3748\/wjg.v23.i34.6261","article-title":"Systemic immune-inflammation index for predicting prognosis of colorectal cancer","volume":"23","author":"Chen JH","year":"2017","unstructured":"Chen JH, Zhai ET, Yuan YJ, Wu KM, Xu JB, Peng JJ, et\u00a0al. Systemic immune-inflammation index for predicting prognosis of colorectal cancer. World J Gastroenterol 2017; 23(34): 6261\u201372. 10.3748\/wjg.v23.i34.6261https:\/\/doi.org\/10.3748\/wjg.v23.i34.6261"},{"issue":"1","key":"B11","series-title":"Sci Rep","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1038\/s41598-019-39150-0","article-title":"Prognostic value of preoperative systemic immune-inflammation index in patients with cervical cancer","volume":"9","author":"Huang H","year":"2019","unstructured":"Huang H, Liu Q, Zhu L, Zhang Y, Lu X, Wu Y, et\u00a0al. Prognostic value of preoperative systemic immune-inflammation index in patients with cervical cancer. Sci Rep 2019; 9(1): 3284. 10.1038\/s41598-019-39150-0https:\/\/doi.org\/10.1038\/s41598-019-39150-0"},{"issue":"1","key":"B12","series-title":"Sci Rep","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67285-y","article-title":"The geriatric nutritional risk index predicts postoperative complications and prognosis in elderly patients with colorectal cancer after curative surgery","volume":"10","author":"Sasaki M","year":"2020","unstructured":"Sasaki M, Miyoshi N, Fujino S, Ogino T, Takahashi H, Uemura M, et\u00a0al. The geriatric nutritional risk index predicts postoperative complications and prognosis in elderly patients with colorectal cancer after curative surgery. Sci Rep 2020; 10(1): 10744. 10.1038\/s41598-020-67285-yhttps:\/\/doi.org\/10.1038\/s41598-020-67285-y"},{"issue":"2","key":"B13","series-title":"CA Cancer J Clin","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin MB","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et\u00a0al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin 2017; 67(2): 93\u20139. 10.3322\/caac.21388https:\/\/doi.org\/10.3322\/caac.21388"},{"issue":"2","key":"B14","series-title":"J Pediatr Surg","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jpedsurg.2019.10.032","article-title":"Application of the Clavien-Dindo classification to a pediatric surgical network","volume":"55","author":"Thompson H","year":"2020","unstructured":"Thompson H, Jones C, Pardy C, Kufeji D, Nichols E, Murphy F, et\u00a0al. Application of the Clavien-Dindo classification to a pediatric surgical network. J Pediatr Surg 2020; 55(2): 312\u20135. 10.1016\/j.jpedsurg.2019.10.032https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.10.032"},{"issue":"1","key":"B15","series-title":"Chaos","doi-asserted-by":"publisher","DOI":"10.1063\/1.4794793","article-title":"Short desynchronization episodes prevail in synchronous dynamics of human brain rhythms","volume":"23","author":"Ahn S","year":"2013","unstructured":"Ahn S, Rubchinsky LL. Short desynchronization episodes prevail in synchronous dynamics of human brain rhythms. Chaos 2013; 23(1): 013138. 10.1063\/1.4794793https:\/\/doi.org\/10.1063\/1.4794793"},{"issue":"6","key":"B16","series-title":"Vivo","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.21873\/invivo.11430","article-title":"The preoperative geriatric nutritional risk index predicts postoperative complications in elderly patients with gastric cancer undergoing gastrectomy","volume":"32","author":"Kushiyama S","year":"2018","unstructured":"Kushiyama S, Sakurai K, Kubo N, Tamamori Y, Nishii T, Tachimori A, et\u00a0al. The preoperative geriatric nutritional risk index predicts postoperative complications in elderly patients with gastric cancer undergoing gastrectomy. Vivo 2018; 32(6): 1667\u201372. 10.21873\/invivo.11430https:\/\/doi.org\/10.21873\/invivo.11430"},{"issue":"8","key":"B17","series-title":"Brain Behav","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2718","article-title":"Geriatric nutritional risk index is related to the risk of stroke-associated pneumonia","volume":"12","author":"Dai C","year":"2022","unstructured":"Dai C, Yan D, Xu M, Huang Q, Ren W. Geriatric nutritional risk index is related to the risk of stroke-associated pneumonia. Brain Behav 2022; 12(8): e2718. 10.1002\/brb3.2718https:\/\/doi.org\/10.1002\/brb3.2718"},{"issue":"22","key":"B18","series-title":"Cancers (Basel)","doi-asserted-by":"publisher","first-page":"5852","DOI":"10.3390\/cancers13225852","article-title":"The clinical utility of the geriatric nutritional risk index in predicting postoperative complications and long-term survival in elderly patients with colorectal cancer after curative surgery","volume":"13","author":"Liao CK","year":"2021","unstructured":"Liao CK, Chern YJ, Hsu YJ, Lin YC, Yu YL, Chiang JM, et\u00a0al. The clinical utility of the geriatric nutritional risk index in predicting postoperative complications and long-term survival in elderly patients with colorectal cancer after curative surgery. Cancers (Basel) 2021; 13(22): 5852. 10.3390\/cancers13225852https:\/\/doi.org\/10.3390\/cancers13225852"},{"issue":"5","key":"B19","series-title":"Eur J Clin Invest","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13230","article-title":"Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease","volume":"50","author":"Yang YL","year":"2020","unstructured":"Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL, et\u00a0al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest 2020; 50(5): e13230. 10.1111\/eci.13230https:\/\/doi.org\/10.1111\/eci.13230"},{"key":"B20","series-title":"Front Nutr","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.981533","article-title":"Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer","volume":"9","author":"Ding P","year":"2022","unstructured":"Ding P, Lv J, Sun C, Chen S, Yang P, Tian Y, et\u00a0al. Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer. Front Nutr 2022; 9: 981533. 10.3389\/fnut.2022.981533https:\/\/doi.org\/10.3389\/fnut.2022.981533"}],"container-title":["Physiology International"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/2060\/112\/4\/article-p445.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/2060\/112\/4\/article-p445.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/2060\/112\/4\/article-p445.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:32:24Z","timestamp":1765474344000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/2060\/112\/4\/article-p445.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":20,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1556\/2060.2025.00690","relation":{},"ISSN":["2498-602X","2677-0164"],"issn-type":[{"value":"2498-602X","type":"print"},{"value":"2677-0164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}