{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:58:35Z","timestamp":1792159115641,"version":"4.4.0"},"reference-count":20,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["PHYSINT"],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether short-term dehydration and hyperhydration affect OCT-derived retinal thickness in healthy young adults in a randomized cross-over design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty volunteers aged 18\u201335 years completed two morning sessions \u22657 days apart: 12-h fluid restriction, representing relative dehydration, and water loading, defined as \u22652\u2009L within 4\u2009h. Spectral-domain OCT (Zeiss Cirrus HD-OCT 7000) was performed by a masked examiner. Primary outcomes were central subfield thickness (CST) and mean peripapillary retinal nerve fiber layer (RNFL) thickness; secondary outcomes were cube average thickness (CAT) and ganglion cell\u2013inner plexiform layer (GCL\u2013IPL) thickness. Hydration was documented using a self-reported thirst scale and recorded water intake. Within-subject comparisons used the Wilcoxon signed-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 28.5 years and 65% of participants were female. Thirst was higher during dehydration than hyperhydration (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). After review of OCT outputs and exclusion of outlying paired observations for GCL\u2013IPL and CAT, the direction and statistical interpretation of the findings remained unchanged. CAT was slightly lower during dehydration in both eyes. CST was lower during dehydration in the left eye, with a similar non-significant trend in the right eye. RNFL thickness did not differ between hydration states in either eye. GCL\u2013IPL thickness showed only a small right-eye difference and no significant difference in the left eye.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute fluid restriction was associated with small reductions in macular OCT thickness measures, whereas RNFL thickness remained stable. The\u00a0magnitude of these changes was modest and close to expected OCT test\u2013retest variability, suggesting limited clinical relevance for routine individual interpretation but potential relevance for highly standardized\u00a0research or longitudinal imaging settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/2060.2026.00843","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:42:18Z","timestamp":1786106538000},"page":"366-381","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dehydration and hyperhydration on\u00a0macular and peripapillary retinal thickness assessed by OCT"],"prefix":"10.1556","volume":"113","author":[{"given":"Jelena","family":"\u0106urkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dea","family":"Samard\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Barun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Okma\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Matijevi\u0107","sequence":"additional","affiliation":[{"name":"University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Kumri\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"},{"name":"Laboratory for Cardiometabolic Research, University of Split School of Medicine, Split, Croatia"},{"name":"Department of Cardiovascular Diseases, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0161ko","family":"Bo\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-9714","authenticated-orcid":true,"given":"Ante","family":"Kre\u0161o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Front Physiol","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fphys.2017.00036","article-title":"Intraocular pressure is a poor predictor of hydration status following intermittent exercise in the heat","volume":"8","author":"Stewart IB","year":"2017 Feb 1","unstructured":"Stewart IB, Dias B, Borg DN, Bach AJE, Feigl B, Costello JT. 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