{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:56:46Z","timestamp":1792159006120,"version":"4.4.0"},"reference-count":75,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["PHYSINT"],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus and metabolic diseases are increasing worldwide and are closely linked to mitochondrial dysfunction. Mitochondrial-derived peptides (MDPs), such as humanin and MOTS-c, play a role in regulating energy balance and cellular stress responses. Exercise is known to improve metabolic function and stimulate MDP synthesis through mitochondria-dependent signaling pathways. Understanding these mechanisms has the potential to uncover new therapeutic targets for the treatment of metabolic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research objectives<\/jats:title>\n                    <jats:p>This study sought to ascertain how physical activity affected MDPs levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review searched four electronic databases, PubMed, Scopus, Web of Science, and ScienceDirect, for studies published between 2016 and 2025 that examined MDPs and exercise. A total of 435 records were identified. After screening according to predefined inclusion and exclusion criteria following PRISMA guidelines, nine studies were included in the final analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the nine studies included in this systematic review, most reported a trend toward increased MDP levels after exercise. However, these findings should be interpreted with caution due to the limited number of studies and variations in study design, subject characteristics, and exercise protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Available evidence suggests that physical exercise has the potential to increase MDP levels, which may be associated with improved metabolic function, increased insulin sensitivity, and the efficiency of cellular energy metabolism. However, current evidence is limited, particularly in human studies. Therefore, further research, particularly controlled clinical trials and longitudinal studies, is needed to confirm these findings and evaluate MDP's potential as a therapeutic target in the prevention and management of metabolic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/2060.2026.00863","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:39:43Z","timestamp":1787654383000},"page":"327-349","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for\u00a0metabolic disorders: A systematic review"],"prefix":"10.1556","volume":"113","author":[{"given":"Novadri","family":"Ayubi","sequence":"first","affiliation":[{"name":"Department of Physical Education Health and Recreation, Faculty of Sports and Health Sciences, Universitas Negeri Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junian Cahyanto","family":"Wibawa","sequence":"additional","affiliation":[{"name":"Department of Physical Education Health and Recreation, STKIP PGRI Trenggalek, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Kurnaz","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports Teaching, Faculty of Sport Science, Hali\u00e7 University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Komaini","sequence":"additional","affiliation":[{"name":"Department of Sports Science, Faculty of Sport Science, Universitas Negeri Padang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"September","key":"B1","series-title":"Front Nutr","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnut.2025.1661603","article-title":"Metabolic syndrome: epidemiology, mechanisms, and current therapeutic approaches","author":"Hamooya BM","year":"2025","unstructured":"Hamooya BM, Siame L, Muchaili L. Metabolic syndrome: epidemiology, mechanisms, and current therapeutic approaches. Front Nutr 2025; (September): 1\u201323. 10.3389\/fnut.2025.1661603https:\/\/doi.org\/10.3389\/fnut.2025.1661603"},{"key":"B2","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020786","article-title":"Metabolic syndrome: updates on pathophysiology and management in 2021","author":"Fahed G","year":"2022","unstructured":"Fahed G, Aoun L, Bou MZ, Allam S, Zerdan BM, Bouferraa Y, et al. Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci 2022. 10.3390\/ijms23020786https:\/\/doi.org\/10.3390\/ijms23020786"},{"key":"B3","series-title":"BMC Endocr Disord","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12902-021-00735-4","article-title":"Understanding the role of oxidative stress in the incidence of metabolic syndrome and obstructive sleep apnea","author":"Kargar B","year":"2021","unstructured":"Kargar B, Zamanian Z, Hosseinabadi MB, Gharibi V, Moradi MS, Cousins R. Understanding the role of oxidative stress in the incidence of metabolic syndrome and obstructive sleep apnea. BMC Endocr Disord 2021; 1\u20138. 10.1186\/s12902-021-00735-4https:\/\/doi.org\/10.1186\/s12902-021-00735-4"},{"key":"B4","series-title":"Nutr Metab","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-025-00978-1","article-title":"Nutrient deficiency and physical inactivity in middle-aged adults with dynapenia and metabolic syndrome: results from a nationwide survey","author":"Kim M","year":"2025","unstructured":"Kim M, Kobori T. Nutrient deficiency and physical inactivity in middle-aged adults with dynapenia and metabolic syndrome: results from a nationwide survey. Nutr Metab 2025; 1\u201315. 10.1186\/s12986-025-00978-1https:\/\/doi.org\/10.1186\/s12986-025-00978-1"},{"key":"B5","series-title":"Balneo PRM Res J","doi-asserted-by":"publisher","first-page":"6","DOI":"10.12680\/balneo.2025.892","article-title":"Physical exercise as A therapy to prevent insulin resistance","author":"Putro BN","year":"2025","unstructured":"Putro BN, Wibawa JC, Putra DP, Ayubi N. Physical exercise as A therapy to prevent insulin resistance. Balneo PRM Res J 2025; 6\u201313. 10.12680\/balneo.2025.892https:\/\/doi.org\/10.12680\/balneo.2025.892"},{"issue":"July","key":"B6","series-title":"Redox Rep","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2016.1205303","article-title":"Mechanisms involved in the development of diabetic retinopathy induced by oxidative stress mechanisms involved in the development of diabetic retinopathy induced by oxidative stress","volume":"0002","author":"Guzman DC","year":"2016","unstructured":"Guzman DC, Olgu\u00edn HJ, Garc\u00eda EH, Peraza AV, de la Cruz DZ, Soto MP. Mechanisms involved in the development of diabetic retinopathy induced by oxidative stress mechanisms involved in the development of diabetic retinopathy induced by oxidative stress. Redox Rep 2016; 0002(July). 10.1080\/13510002.2016.1205303https:\/\/doi.org\/10.1080\/13510002.2016.1205303"},{"key":"B7","series-title":"Diabetes Komplikationen","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1055\/a-1038-0102","article-title":"Diabeteskomplikationen \u2013 diabetes und Nervensystem","author":"Meyh\u00f6fer S","year":"2020","unstructured":"Meyh\u00f6fer S, Schmid SM. Diabeteskomplikationen \u2013 diabetes und Nervensystem. Diabetes Komplikationen 2020; 1599\u2013605. 10.1055\/a-1038-0102https:\/\/doi.org\/10.1055\/a-1038-0102"},{"key":"B8","series-title":"Nat Commun","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-20790-0","article-title":"MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis","author":"Reynolds JC","year":"2021","unstructured":"Reynolds JC, Rochelle WL, Jonathan STW, James HJ, Cameron JM, David CS, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 2021: 1\u201311. 10.1038\/s41467-020-20790-0https:\/\/doi.org\/10.1038\/s41467-020-20790-0"},{"issue":"9","key":"B9","series-title":"Kidney Int Rep","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1016\/j.ekir.2024.05.005","article-title":"The role of mitochondrial dysfunction","volume":"9","author":"Huang J","year":"2024","unstructured":"Huang J, Hao J, Wang P, Xu Y. The role of mitochondrial dysfunction. Kidney Int Rep 2024; 9(9): 2596\u2013607. 10.1016\/j.ekir.2024.05.005https:\/\/doi.org\/10.1016\/j.ekir.2024.05.005"},{"issue":"August","key":"B10","series-title":"Front Pharmacol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","author":"Pang B","year":"2024","unstructured":"Pang B, Dong G, Pang T, Sun X, Liu X, Nie Y, Chang X. Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality. Front Pharmacol 2024; (August): 1\u201310. 10.3389\/fphar.2024.1422686https:\/\/doi.org\/10.3389\/fphar.2024.1422686"},{"issue":"14","key":"B11","series-title":"Theranostics","doi-asserted-by":"publisher","DOI":"10.7150\/thno.60143","article-title":"Theranostics coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control","volume":"11","author":"Chang X","year":"2021","unstructured":"Chang X, Lochner A, Wang HH, Wang S, Zhu H, Ren J, et al. Theranostics coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control. Theranostics 2021; 11(14). 10.7150\/thno.60143https:\/\/doi.org\/10.7150\/thno.60143"},{"issue":"7","key":"B12","series-title":"Mol Cell Biochem","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s11010-023-04909-7","article-title":"The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy","volume":"479","author":"Zhang B","year":"2024","unstructured":"Zhang B, Wu H, Zhang J, Cong C, Zhang L. The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy. Mol Cell Biochem 2024; 479(7): 1673\u201396. 10.1007\/s11010-023-04909-7https:\/\/doi.org\/10.1007\/s11010-023-04909-7"},{"issue":"3","key":"B13","series-title":"Cell Metab","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","article-title":"The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance article the mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance","volume":"21","author":"Lee C","year":"2015","unstructured":"Lee C, Zeng J, De Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance article the mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015; 21(3): 443\u201354. 10.1016\/j.cmet.2015.02.009https:\/\/doi.org\/10.1016\/j.cmet.2015.02.009"},{"issue":"February","key":"B14","series-title":"Front Endocrinol (Lausanne)","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2021.808120","article-title":"Mitochondrial-derived peptides in diabetes and its complications","volume":"12","author":"Wu Y","year":"2022","unstructured":"Wu Y, Sun L, Zhuang Z, Hu X, Dong D. Mitochondrial-derived peptides in diabetes and its complications. Front Endocrinol (Lausanne) 2022; 12(February): 1\u20137. 10.3389\/fendo.2021.808120https:\/\/doi.org\/10.3389\/fendo.2021.808120"},{"key":"B15","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI158449","article-title":"Mitochondria-derived peptides in aging and healthspan","volume":"31","author":"Miller B","year":"2022","unstructured":"Miller B, Kim S, Kumagai H, Yen K, Cohen P. Mitochondria-derived peptides in aging and healthspan. J Clin Invest 2022; 31: 1\u20139. 10.1172\/JCI158449https:\/\/doi.org\/10.1172\/JCI158449"},{"issue":"43","key":"B16","series-title":"Am J Physiol","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00249.2020","article-title":"Mitochondrial-derived peptides in energy metabolism","author":"Merry TL","year":"2026","unstructured":"Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ, et al. Mitochondrial-derived peptides in energy metabolism. Am J Physiol 2026; (43). 10.1152\/ajpendo.00249.2020https:\/\/doi.org\/10.1152\/ajpendo.00249.2020"},{"key":"B17","series-title":"Cell Metab","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2018.06.008","article-title":"Short article the mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress short article the mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear G","author":"Kim KH","year":"2018","unstructured":"Kim KH, Son JM, Benayoun A, Lee C. Short article the mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress short article the mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear G. Cell Metab 2018: 516\u201324. 10.1016\/j.cmet.2018.06.008https:\/\/doi.org\/10.1016\/j.cmet.2018.06.008"},{"issue":"4","key":"B18","series-title":"Aging (Albany. NY)","doi-asserted-by":"publisher","first-page":"796","DOI":"10.18632\/aging.100943","article-title":"Naturally occurring mitochondrial \u2010 derived peptides are age \u2010 dependent regulators of apoptosis , insulin sensitivity , and inflammatory markers","volume":"8","author":"Cobb J","year":"2016","unstructured":"Cobb J, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, et al. Naturally occurring mitochondrial \u2010 derived peptides are age \u2010 dependent regulators of apoptosis , insulin sensitivity , and inflammatory markers. Aging (Albany. NY) 2016; 8(4): 796\u2013808. 10.18632\/aging.100943https:\/\/doi.org\/10.18632\/aging.100943"},{"key":"B19","series-title":"Oxid Med Cell Longev","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4321714","article-title":"Review article cellular stresses and stress responses in the pathogenesis of insulin resistance","volume":"2018","author":"Onyango AN","year":"2018","unstructured":"Onyango AN. Review article cellular stresses and stress responses in the pathogenesis of insulin resistance. Oxid Med Cell Longev 2018; 2018. 10.1155\/2018\/4321714https:\/\/doi.org\/10.1155\/2018\/4321714"},{"issue":"5","key":"B20","series-title":"Cell Metab","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","article-title":"Review metabolic flexibility in health and disease","volume":"25","author":"Goodpaster BH","year":"2017","unstructured":"Goodpaster BH, Sparks LM. Review metabolic flexibility in health and disease. Cell Metab 2017; 25(5): 1027\u201336. 10.1016\/j.cmet.2017.04.015https:\/\/doi.org\/10.1016\/j.cmet.2017.04.015"},{"key":"B21","series-title":"Oxid Med Cell Longev","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7058350","article-title":"Review article stay fit, stay young: Mitochondria in movement: the role of exercise in the new mitochondrial paradigm","volume":"2019","author":"Huertas JR","year":"2019","unstructured":"Huertas JR, Casuso RA, Agust\u00edn PH, Cogliati S. Review article stay fit, stay young: Mitochondria in movement: the role of exercise in the new mitochondrial paradigm. Oxid Med Cell Longev 2019; 2019. 10.1155\/2019\/7058350https:\/\/doi.org\/10.1155\/2019\/7058350"},{"issue":"October 2019","key":"B22","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1152\/japplphysiol.00706.2019","article-title":"Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans","author":"Von Walden F","year":"2021","unstructured":"Von Walden F, Fernandez-Gonzalo R, Norrbom J, Emanuelsson EB, Figueiredo VC, Gidlund EK, et al. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. J Appl Physiol 2021; (October 2019): 1035\u201342. 10.1152\/japplphysiol.00706.2019https:\/\/doi.org\/10.1152\/japplphysiol.00706.2019"},{"key":"B23","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1152\/japplphysiol.00032.2020","article-title":"High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men","author":"Woodhead JST","year":"2020","unstructured":"Woodhead JST, et\u00a0al. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol 2020: 1346\u201354. 10.1152\/japplphysiol.00032.2020https:\/\/doi.org\/10.1152\/japplphysiol.00032.2020"},{"key":"B24","series-title":"Physiol Rep","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13063","article-title":"Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism","volume":"4","author":"Gidlund E","year":"2016","unstructured":"Gidlund E, Von Walden F, Venoj M, Sundberg CJ. Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism. Physiol Rep 2016; 4. 10.14814\/phy2.13063https:\/\/doi.org\/10.14814\/phy2.13063"},{"key":"B25","series-title":"Sci Rep","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-96419-z","article-title":"Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and non - hispanic white breast cancer survivors","author":"Conwright CMD","year":"2021","unstructured":"Conwright CMD, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, et al. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and non - hispanic white breast cancer survivors. Sci Rep 2021: 1\u20137. 10.1038\/s41598-021-96419-zhttps:\/\/doi.org\/10.1038\/s41598-021-96419-z"},{"issue":"5","key":"B26","series-title":"Rev Cardiovasc Med","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2305181","article-title":"The effect of chronic endurance exercise on serum levels of MOTS-c and humanin in professional athletes","volume":"23","author":"Alser M","year":"2022","unstructured":"Alser M, Ramanjaneya M, Rizwana Anwardeen N, Donati F, Botr\u00e8 F, Jerobin J, et al. The effect of chronic endurance exercise on serum levels of MOTS-c and humanin in professional athletes. Rev Cardiovasc Med 2022; 23(5). 10.31083\/j.rcm2305181https:\/\/doi.org\/10.31083\/j.rcm2305181"},{"key":"B27","series-title":"J Cell Mol Med","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jcmm.70396","article-title":"Potential role of High-intensity interval Training-induced increase in humanin levels for the management of type 2 diabetes","author":"Soltany A","year":"2025","unstructured":"Soltany A. Potential role of High-intensity interval Training-induced increase in humanin levels for the management of type 2 diabetes. J Cell Mol Med 2025: 1\u20139. 10.1111\/jcmm.70396https:\/\/doi.org\/10.1111\/jcmm.70396"},{"issue":"May","key":"B28","series-title":"Physiol Rep","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14814\/phy2.15377","article-title":"C increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose","author":"Hyatt JPK","year":"2022","unstructured":"Hyatt JPK. C increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose. Physiol Rep 2022; (May): 1\u201314. 10.14814\/phy2.15377https:\/\/doi.org\/10.14814\/phy2.15377"},{"issue":"0123456789","key":"B29","series-title":"Sci Rep","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-99568-3","article-title":"The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats","author":"Yuan J","year":"2021","unstructured":"Yuan J, Wang M, Pan Y, Liang M, Fu Y, Duan Y, et al. The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats. Sci Rep 2021; (0123456789): 1\u201311. 10.1038\/s41598-021-99568-3https:\/\/doi.org\/10.1038\/s41598-021-99568-3"},{"issue":"7","key":"B30","series-title":"PLoS One","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006334","article-title":"Humanin: a novel central regulator of peripheral insulin action","volume":"4","author":"Muzumdar RH","year":"2009","unstructured":"Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One 2009; 4(7). 10.1371\/journal.pone.0006334https:\/\/doi.org\/10.1371\/journal.pone.0006334"},{"key":"B31","series-title":"Life Sci","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118679","article-title":"Humanin: a mitochondrial-derived peptide in the treatment of apoptosis-related diseases","author":"Abu Hazafaa UG","year":"2020","unstructured":"Abu Hazafaa UG, Batoola A, Ahmadb S, Amjadc M, Chaudhrya SN, Asadd J, et\u00a0al. Humanin: a mitochondrial-derived peptide in the treatment of apoptosis-related diseases. Life Sci 2020; 118679. 10.1016\/j.lfs.2020.118679https:\/\/doi.org\/10.1016\/j.lfs.2020.118679"},{"issue":"April","key":"B32","series-title":"Biomed Pharmacother","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109075","article-title":"The role of mitochondria-derived peptides in cardiovascular disease: recent updates","volume":"117","author":"Yang Y","year":"2019","unstructured":"Yang Y, Gao H, Zhou H, Liu Q, Qi Z, Zhang Y, et al. The role of mitochondria-derived peptides in cardiovascular disease: recent updates. Biomed Pharmacother 2019; 117(April): 109075. 10.1016\/j.biopha.2019.109075https:\/\/doi.org\/10.1016\/j.biopha.2019.109075"},{"issue":"December 2024","key":"B33","series-title":"Eur J Pharmacol","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177510","article-title":"The neuroprotective role of Humanin in Alzheimer's disease: the molecular effects","volume":"998","author":"Alqahtani SM","year":"2025","unstructured":"Alqahtani SM, Al-Kuraishy HM, Al-Gareeb AL, Alexiou A, Fawzy MN, Papadakis M, et al. The neuroprotective role of Humanin in Alzheimer's disease: the molecular effects. Eur J Pharmacol 2025; 998(December 2024): 177510. 10.1016\/j.ejphar.2025.177510https:\/\/doi.org\/10.1016\/j.ejphar.2025.177510"},{"key":"B34","series-title":"Int J Cardiol","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ijcard.2018.03.031","article-title":"MOTS-c attenuates endothelial dysfunction via suppressing the MAPK\/NF- \u03ba B pathway","volume":"268","author":"Li H","year":"2018","unstructured":"Li H, Ren K, Jiang T, Zhao G. MOTS-c attenuates endothelial dysfunction via suppressing the MAPK\/NF- \u03ba B pathway. Int J Cardiol 2018; 268: 40. 10.1016\/j.ijcard.2018.03.031https:\/\/doi.org\/10.1016\/j.ijcard.2018.03.031"},{"issue":"3","key":"B35","series-title":"Cell Metab","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.cmet.2018.08.017","article-title":"Previews A mitochondrial-derived peptide","volume":"28","author":"Mangalhara KC","year":"2018","unstructured":"Mangalhara KC, Shadel GS. Previews A mitochondrial-derived peptide. Cell Metab 2018; 28(3): 330\u201331. 10.1016\/j.cmet.2018.08.017https:\/\/doi.org\/10.1016\/j.cmet.2018.08.017"},{"key":"B36","series-title":"Nat Publ Gr","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","author":"Quir\u00f3s PM","year":"2016","unstructured":"Quir\u00f3s PM, Mottis A, Auwerx J. Mitonuclear communication in homeostasis and stress. Nat Publ Gr 2016. 10.1038\/nrm.2016.23https:\/\/doi.org\/10.1038\/nrm.2016.23"},{"key":"B37","series-title":"Retos","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.47197\/retos.v68.115136","article-title":"Increased adenosine monophosphate\u2013activated protein kinase activity in mice with physical exercise intervention: a systematic review","volume":"2025","author":"Suryanto Agung Prabowo NA","year":"2025","unstructured":"Suryanto Agung Prabowo NA, Wibawa JC, Hamdani H, Indriarsa N, Ardha MAAl, Hidayat T, et\u00a0al. Increased adenosine monophosphate\u2013activated protein kinase activity in mice with physical exercise intervention: a systematic review. Retos 2025; 2025: 1054\u201363. 10.47197\/retos.v68.115136https:\/\/doi.org\/10.47197\/retos.v68.115136"},{"key":"B38","series-title":"Oxid Med Cell Longev","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3846122","article-title":"Effects of exercise-induced ROS on the pathophysiological functions of skeletal muscle","volume":"2021","author":"Wang F","year":"2021","unstructured":"Wang F, Wang X, Liu Y, Zhang Z. Effects of exercise-induced ROS on the pathophysiological functions of skeletal muscle. Oxid Med Cell Longev 2021; 2021. 10.1155\/2021\/3846122https:\/\/doi.org\/10.1155\/2021\/3846122"},{"issue":"1","key":"B39","series-title":"Nutrients","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010222","article-title":"Effects of high-intensity anaerobic exercise on the scavenging activity of various reactive oxygen species and free radicals in athletes","volume":"15","author":"Sawada Y","year":"2023","unstructured":"Sawada Y, Ichikawa H, Ebine N, Minamiyama Y, Alharbi AAD, Iwamoto N, et al. Effects of high-intensity anaerobic exercise on the scavenging activity of various reactive oxygen species and free radicals in athletes. Nutrients 2023; 15(1). 10.3390\/nu15010222https:\/\/doi.org\/10.3390\/nu15010222"},{"issue":"4","key":"B40","series-title":"Gene Cell Tissue","doi-asserted-by":"publisher","DOI":"10.5812\/gct-131964","article-title":"The effect of aerobic exercise on oxidative stress in skeletal muscle tissue: a narrative review","volume":"10","author":"Shamsnia E","year":"2023","unstructured":"Shamsnia E, Matinhomaee H, Azarbayjani MA, Peeri M. The effect of aerobic exercise on oxidative stress in skeletal muscle tissue: a narrative review. Gene Cell Tissue 2023; 10(4). 10.5812\/gct-131964https:\/\/doi.org\/10.5812\/gct-131964"},{"issue":"5","key":"B41","series-title":"J Sport Heal Sci","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jshs.2020.04.001","article-title":"Exercise-induced oxidative stress: friend or foe?","volume":"9","author":"Powers SK","year":"2020","unstructured":"Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: friend or foe? J Sport Heal Sci 2020; 9(5): 415\u201325. 10.1016\/j.jshs.2020.04.001https:\/\/doi.org\/10.1016\/j.jshs.2020.04.001"},{"issue":"3","key":"B42","series-title":"Indian J Forensic Med Toxicol","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.37506\/ijfmt.v15i3.15824","article-title":"Ascorbic acid drink after submaximal physical activity can maintain the superoxide dismutase levels in East Java student regiment","volume":"15","author":"Wibawa JC","year":"2021","unstructured":"Wibawa JC, Arifin MZ, Herawati L. Ascorbic acid drink after submaximal physical activity can maintain the superoxide dismutase levels in East Java student regiment. Indian J Forensic Med Toxicol 2021; 15(3): 3383\u201392. 10.37506\/ijfmt.v15i3.15824https:\/\/doi.org\/10.37506\/ijfmt.v15i3.15824"},{"issue":"8","key":"B43","series-title":"J Diabetes Investig","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/jdi.14043","article-title":"Diet and exercise are a fundamental part of comprehensive care for type 2 diabetes","volume":"14","author":"Yeh YK","year":"2023","unstructured":"Yeh YK, Yen FS, Hwu CM. Diet and exercise are a fundamental part of comprehensive care for type 2 diabetes. J Diabetes Investig 2023; 14(8): 936\u20139. 10.1111\/jdi.14043https:\/\/doi.org\/10.1111\/jdi.14043"},{"issue":"217","key":"B44","series-title":"Apunt Sport Med","doi-asserted-by":"publisher","DOI":"10.1016\/j.apunsm.2023.100404","article-title":"Effects of high-intensity intermittent training on some in fl ammatory and muscle damage indices in overweight middle-aged men","volume":"58","author":"Rohnejad B","year":"2023","unstructured":"Rohnejad B, Monazzami A. Effects of high-intensity intermittent training on some in fl ammatory and muscle damage indices in overweight middle-aged men. Apunt Sport Med 2023; 58(217): 100404. 10.1016\/j.apunsm.2023.100404https:\/\/doi.org\/10.1016\/j.apunsm.2023.100404"},{"issue":"2","key":"B45","series-title":"Al-Rafidain J Med Sci","doi-asserted-by":"publisher","first-page":"58","DOI":"10.54133\/ajms.v9i2.2148","article-title":"Molecular mechanism of physical exercise in increasing genetic expression of Sirtuin 1 (SIRT1): a systematic review","volume":"9","author":"Ayubi N","year":"2025","unstructured":"Ayubi N, Wibawa JC, Komaini A, Rizki AZ, Afandi A, Aljunaid M, et\u00a0al. Molecular mechanism of physical exercise in increasing genetic expression of Sirtuin 1 (SIRT1): a systematic review. Al-Rafidain J Med Sci 2025; 9(2): 58\u201364. 10.54133\/ajms.v9i2.2148https:\/\/doi.org\/10.54133\/ajms.v9i2.2148"},{"issue":"19","key":"B46","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911025","article-title":"Molecular mechanisms underlying Ca2+\/Calmodulin-Dependent protein kinase kinase Signal transduction","volume":"23","author":"Tokumitsu H","year":"2022","unstructured":"Tokumitsu H, Sakagami H. Molecular mechanisms underlying Ca2+\/Calmodulin-Dependent protein kinase kinase Signal transduction. Int J Mol Sci 2022; 23(19). 10.3390\/ijms231911025https:\/\/doi.org\/10.3390\/ijms231911025"},{"key":"B47","series-title":"Diabetes, Metab Syndr Obes","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.2147\/DMSO.S328694","article-title":"Combination of metformin and exercise in management of metabolic abnormalities observed in type 2 diabetes mellitus","volume":"14","author":"Jevtovic F","year":"2021","unstructured":"Jevtovic F. Combination of metformin and exercise in management of metabolic abnormalities observed in type 2 diabetes mellitus. Diabetes, Metab Syndr Obes 2021; 14: 4043\u201357. 10.2147\/DMSO.S328694https:\/\/doi.org\/10.2147\/DMSO.S328694"},{"issue":"10","key":"B48","series-title":"Front Biosci - Landmark","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2810250","article-title":"The role and application of the AMPK-Sirtuins network in cellular senescence","volume":"28","author":"Han Y","year":"2023","unstructured":"Han Y, Liu Y, Zhang Y, Wang W, Lv T, Huang J, et al. The role and application of the AMPK-Sirtuins network in cellular senescence. Front Biosci - Landmark 2023; 28(10). 10.31083\/j.fbl2810250https:\/\/doi.org\/10.31083\/j.fbl2810250"},{"issue":"5","key":"B49","series-title":"Cell","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cell.2020.02.008","article-title":"Caloric restriction reprograms the single-cell transcriptional landscape of Rattus Norvegicus aging","volume":"180","author":"Ma S","year":"2020","unstructured":"Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, et al. Caloric restriction reprograms the single-cell transcriptional landscape of Rattus Norvegicus aging. Cell 2020; 180(5): 984\u20131001.e22. 10.1016\/j.cell.2020.02.008https:\/\/doi.org\/10.1016\/j.cell.2020.02.008"},{"key":"B50","series-title":"Retos","doi-asserted-by":"publisher","first-page":"610","DOI":"10.47197\/retos.v63.108856","article-title":"El mecanismo del ejercicio f\u00edsico aumenta la glutati\u00f3n peroxidasa como antioxidante end\u00f3geno: una revisi\u00f3n sistem\u00e1tica Authors How to cite in APA Keywords Resumen Palabras clave","volume":"2025","author":"Wibawa JC","year":"2025","unstructured":"Wibawa JC, Febrianto N, Fudin MS, Ockta Y, Festiawan R. El mecanismo del ejercicio f\u00edsico aumenta la glutati\u00f3n peroxidasa como antioxidante end\u00f3geno: una revisi\u00f3n sistem\u00e1tica Authors How to cite in APA Keywords Resumen Palabras clave. Retos 2025; 2025: 610\u20139. 10.47197\/retos.v63.108856https:\/\/doi.org\/10.47197\/retos.v63.108856"},{"issue":"11","key":"B51","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms20112717","article-title":"Exercise and sirtuins: a way to mitochondrial health in skeletal muscle","volume":"20","author":"Vargas-Ortiz K","year":"2019","unstructured":"Vargas-Ortiz K, P\u00e9rez-V\u00e1zquez V, Mac\u00edas-Cervantes MH. Exercise and sirtuins: a way to mitochondrial health in skeletal muscle. Int J Mol Sci 2019; 20(11): 1\u201311. 10.3390\/ijms20112717https:\/\/doi.org\/10.3390\/ijms20112717"},{"key":"B52","series-title":"Antioxidants","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051075","article-title":"PGC-1 \u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response","author":"Shelbayeh OA","year":"2023","unstructured":"Shelbayeh OA, Arroum T, Morris S, Busch KB. PGC-1 \u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response. Antioxidants 2023. 10.3390\/antiox12051075https:\/\/doi.org\/10.3390\/antiox12051075"},{"key":"B53","series-title":"Antioxidants","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox11112155","article-title":"Novel therapeutic approaches enhance PGC1-alpha to reduce oxidant stress-inflammatory signaling and improve functional recovery in hibernating myocardium","author":"Aggarwal R","year":"2022","unstructured":"Aggarwal R, Potel KN, Mcfalls EO, Butterick TA, Kelly RF. Novel therapeutic approaches enhance PGC1-alpha to reduce oxidant stress-inflammatory signaling and improve functional recovery in hibernating myocardium. Antioxidants 2022; 1\u201313. 10.3390\/antiox11112155https:\/\/doi.org\/10.3390\/antiox11112155"},{"issue":"9","key":"B54","series-title":"BBA - Mol Cell Res","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119300","article-title":"BBA-Molecular cell research GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R\/AMPK pathway","volume":"1869","author":"Wu L","year":"2022","unstructured":"Wu L, Zhou M, Li T, Dong N, Yi L, Zhang Q, et al. BBA-Molecular cell research GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R\/AMPK pathway. BBA - Mol Cell Res 2022; 1869(9): 119300. 10.1016\/j.bbamcr.2022.119300https:\/\/doi.org\/10.1016\/j.bbamcr.2022.119300"},{"issue":"1","key":"B55","series-title":"Medicni Perspekt","doi-asserted-by":"publisher","first-page":"27","DOI":"10.26641\/2307-0404.2025.2.333361","article-title":"Physiological regulation of peroxisome proliferator-activated receptor-famma coactivator 1 alpha in mitochondrial metabolism during physical exercises: a systematic review","volume":"8","author":"Ayubi N","year":"2025","unstructured":"Ayubi N, Wibawa JC, Rizki AZ, Afandi A. Physiological regulation of peroxisome proliferator-activated receptor-famma coactivator 1 alpha in mitochondrial metabolism during physical exercises: a systematic review. Medicni Perspekt 2025; 8(1): 27\u201337. 10.26641\/2307-0404.2025.2.333361https:\/\/doi.org\/10.26641\/2307-0404.2025.2.333361"},{"issue":"June","key":"B56","series-title":"Pharmacol Res","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105725","article-title":"Resveratrol and endothelial function: a literature review","volume":"170","author":"Parsamanesh N","year":"2021","unstructured":"Parsamanesh N, Asghari A, Sardari S, Tasbandi A, Jamialahmadi T, Xu S, et al. Resveratrol and endothelial function: a literature review. Pharmacol Res 2021; 170(June): 105725. 10.1016\/j.phrs.2021.105725https:\/\/doi.org\/10.1016\/j.phrs.2021.105725"},{"issue":"9","key":"B57","series-title":"Neurochem Res","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1007\/s11064-019-02858-6","article-title":"Role of PGC-1\u03b1 in mitochondrial quality control in neurodegenerative diseases","volume":"44","author":"Zhang Q","year":"2019","unstructured":"Zhang Q, Hong YL, Zhou JP, Hou YY, Wan Z, Wang HL, et al. Role of PGC-1\u03b1 in mitochondrial quality control in neurodegenerative diseases. Neurochem Res 2019; 44(9): 2031\u201343. 10.1007\/s11064-019-02858-6https:\/\/doi.org\/10.1007\/s11064-019-02858-6"},{"issue":"October","key":"B58","series-title":"Front Endocrinol","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1452993","article-title":"Targeting AMP-activated protein kinase in sepsis","author":"Yumoto T","year":"2024","unstructured":"Yumoto T, Coopersmith CM. Targeting AMP-activated protein kinase in sepsis. Front Endocrinol 2024; (October). 10.3389\/fendo.2024.1452993https:\/\/doi.org\/10.3389\/fendo.2024.1452993"},{"issue":"1","key":"B59","series-title":"Cell Death Discov","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41420-024-01953-0","article-title":"PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration","volume":"10","author":"You W","year":"2024","unstructured":"You W, Knoops K, Berendschot TTJM, Benedikter BJ, Webers CAB, Reutelingsperger CPM, et al. PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration. Cell Death Discov 2024; 10(1): 1\u201315. 10.1038\/s41420-024-01953-0https:\/\/doi.org\/10.1038\/s41420-024-01953-0"},{"issue":"May","key":"B60","series-title":"Biochem J","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1042\/BCJ20253237","article-title":"High tide or low tide: the transport and metabolism of mitochondrial nucleotides","volume":"0","author":"Macvicar T","year":"2025","unstructured":"Macvicar T. High tide or low tide: the transport and metabolism of mitochondrial nucleotides. Biochem J 2025; 0(May): 1105\u201322. 10.1042\/BCJ20253237https:\/\/doi.org\/10.1042\/BCJ20253237"},{"key":"B61","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242317124","article-title":"Role of mitochondria in inflammatory bowel diseases: a systematic review","author":"Rodr C","year":"2023","unstructured":"Rodr C, Rodr FJ. Role of mitochondria in inflammatory bowel diseases: a systematic review. Int J Mol Sci 2023. 10.3390\/ijms242317124https:\/\/doi.org\/10.3390\/ijms242317124"},{"key":"B62","series-title":"Elife","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.108742","article-title":"Suppression of interferon signaling via molecule modulation of TFAM","author":"Sideris D","year":"2025","unstructured":"Sideris D, Lee H, Olson L, Nallaparaju K, Okuyama K, Ciavarri J, et al. Suppression of interferon signaling via molecule modulation of TFAM. Elife 2025: 1\u201315. 10.7554\/eLife.108742https:\/\/doi.org\/10.7554\/eLife.108742"},{"issue":"May","key":"B63","series-title":"Free Radic Biol Med","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2024.05.032","article-title":"Free radical biology and medicine disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome","volume":"222","author":"Li Y","year":"2024","unstructured":"Li Y, Tian L, Li S, Chen X, Lei F, Bao J, et al. Free radical biology and medicine disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome. Free Radic Biol Med 2024; 222(May): 106\u201321. 10.1016\/j.freeradbiomed.2024.05.032https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.05.032"},{"issue":"3","key":"B64","series-title":"Cell","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Review mitochondrial ROS signaling","volume":"163","author":"Gerald SS","year":"2015","unstructured":"Gerald SS, Horvath TL. Review mitochondrial ROS signaling. Cell 2015; 163(3): 560\u20139. 10.1016\/j.cell.2015.10.001https:\/\/doi.org\/10.1016\/j.cell.2015.10.001"},{"issue":"2","key":"B65","series-title":"Obes Res","first-page":"133","article-title":"Exercise and obesity","volume":"1","author":"Bouchard C","year":"1993","unstructured":"Bouchard C, Deprks J, Trernbluy A. Exercise and obesity. Obes Res 1993; 1(2): 133\u201347."},{"key":"B66","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1152\/japplphysiol.00032.2020","article-title":"High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men","author":"Woodhead JST","year":"2020","unstructured":"Woodhead JST, D\u2019Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, et al. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol 2020: 1346\u201354. 10.1152\/japplphysiol.00032.2020https:\/\/doi.org\/10.1152\/japplphysiol.00032.2020"},{"issue":"2","key":"B67","series-title":"J Cell Biol.","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1083\/jcb.201606095","article-title":"Humanin is an endogenous activator of chaperone- mediated autophagy","volume":"217","author":"Gong Z","year":"2018","unstructured":"Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, et al. Humanin is an endogenous activator of chaperone- mediated autophagy. J Cell Biol. 2018; 217(2): 635\u201347. 10.1083\/jcb.201606095https:\/\/doi.org\/10.1083\/jcb.201606095"},{"issue":"June","key":"B68","series-title":"Front Endocrinol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2021.683151","article-title":"Protective mechanism of humanin against oxidative stress in Aging- related cardiovascular diseases","volume":"12","author":"Cai H","year":"2021","unstructured":"Cai H, Liu Y, Men H, Zheng Y. Protective mechanism of humanin against oxidative stress in Aging- related cardiovascular diseases. Front Endocrinol 2021; 12(June): 1\u201313. 10.3389\/fendo.2021.683151https:\/\/doi.org\/10.3389\/fendo.2021.683151"},{"issue":"25","key":"B69","series-title":"Oncotarget","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4770","article-title":"Exercise for the heart: signaling pathways","volume":"6","author":"Tao L","year":"2015","unstructured":"Tao L, Bei Y, Zhang H, Xiao J, Li X. Exercise for the heart: signaling pathways. Oncotarget 2015; 6(25). 10.18632\/oncotarget.4770https:\/\/doi.org\/10.18632\/oncotarget.4770"},{"issue":"6","key":"B70","series-title":"BBA - Mol Basis Dis","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166126","article-title":"MOTS-c interacts synergistically with exercise intervention to regulate PGC-1\u03b1 expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway","volume":"1867","author":"Yang B","year":"2021","unstructured":"Yang B, Yu Q, Chang B, Guo Q, Xu S, Yi X, et al. MOTS-c interacts synergistically with exercise intervention to regulate PGC-1\u03b1 expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway. BBA - Mol Basis Dis 2021; 1867(6): 166126. 10.1016\/j.bbadis.2021.166126https:\/\/doi.org\/10.1016\/j.bbadis.2021.166126"},{"key":"B71","series-title":"Diabetologia","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1007\/s00125-020-05269-3","article-title":"Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1\u2013SIRT1\u2013PGC-1\u03b1","author":"Guo Q","year":"2020","unstructured":"Guo Q, Chang B, Yu Q, Xu S, Yi X, Cao S. Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1\u2013SIRT1\u2013PGC-1\u03b1. Diabetologia 2020: 2675\u201388. 10.1007\/s00125-020-05269-3https:\/\/doi.org\/10.1007\/s00125-020-05269-3"},{"issue":"2","key":"B72","series-title":"Cell Metab","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cmet.2021.01.003","article-title":"Article mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism ll article mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism","volume":"33","author":"Kang GM","year":"2021","unstructured":"Kang GM, Min SH, Lee CH, Lee C, Shong M, Kim M. Article mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism ll article mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism. Cell Metab 2021; 33(2): 334\u2013349.e6. 10.1016\/j.cmet.2021.01.003https:\/\/doi.org\/10.1016\/j.cmet.2021.01.003"},{"key":"B73","series-title":"Cardio Ren Med","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000503224","article-title":"Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway","volume":"710021","author":"Wei M","year":"2020","unstructured":"Wei M, Gan L, Liu Z, Liu L, Chang JR, Yin DC, et al. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway. Cardio Ren Med 2020; 710021: 42\u201350. 10.1159\/000503224https:\/\/doi.org\/10.1159\/000503224"},{"key":"B74","series-title":"Int J Cardiol","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.001","article-title":"Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction","author":"Qin Q","year":"2017","unstructured":"Qin Q, Delrio S, Wan J, Jay WR, Cohen P, Lerman LO, et al. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol 2017. 10.1016\/j.ijcard.2017.12.001https:\/\/doi.org\/10.1016\/j.ijcard.2017.12.001"},{"issue":"March","key":"B75","series-title":"Front Endocrinol (Lausanne)","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2022.812032","article-title":"MOTS-c and exercise restore cardiac function by activating of NRG1-ErbB signaling in diabetic rats","volume":"13","author":"Li S","year":"2022","unstructured":"Li S, Wang M, Ma J, Pang X, Yuan J. MOTS-c and exercise restore cardiac function by activating of NRG1-ErbB signaling in diabetic rats. Front Endocrinol (Lausanne) 2022; 13(March): 1\u201312. 10.3389\/fendo.2022.812032https:\/\/doi.org\/10.3389\/fendo.2022.812032"}],"container-title":["Physiology International"],"original-title":[],"link":[{"URL":"https:\/\/www.akjournals.com\/view\/journals\/2060\/113\/3\/article-p327.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/2060\/113\/3\/article-p327.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/2060\/113\/3\/article-p327.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:32:42Z","timestamp":1792157562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akjournals.com\/view\/journals\/2060\/113\/3\/article-p327.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":75,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/2060.2026.00863","relation":{},"ISSN":["2498-602X","2677-0164"],"issn-type":[{"value":"2498-602X","type":"print"},{"value":"2677-0164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]}}}