{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:00:14Z","timestamp":1697814014078},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p> Chronic hepatitis C virus infection associated with necroinflammation predisposes to liver fibrosis and cirrhosis, which lead to severe end-stage complications. Staging of fibrosis is of basic importance for the indication of antiviral treatment, for monitoring the response and predicting the prognosis of patients with hepatitis C virus related liver disease. Since liver biopsy, the \u201cgold standard\u201d diagnosis of fibrosis is invasive and it has some other limitations, non-invasive methods have been developed and widely used in the clinical practice. Serum biomarkers and physical approaches measuring liver stiffness by elastography as well as combination algorithms have been gradually been integrated into guidelines resulting in a reduction of the need for liver biopsy. The authors review these non-invasive fibrosis markers and discuss their role in the indication of treatment, follow-up, and assessment of prognosis of patients with chronic hepatitis C virus infection. Orv. Hetil., 2015, 156(21), 855\u2013861. <\/jats:p>","DOI":"10.1556\/650.2015.30173","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T16:56:52Z","timestamp":1432227412000},"page":"855-861","source":"Crossref","is-referenced-by-count":1,"title":["Nem invaz\u00edv fibrosisdiagnosztika hepatitis                     C-v\u00edrus-infekci\u00f3ban: szerepe a kezel\u00e9s indik\u00e1ci\u00f3j\u00e1ban, k\u00f6vet\u00e9s\u00e9ben \u00e9s a                     progn\u00f3zis meg\u00edt\u00e9l\u00e9s\u00e9ben"],"prefix":"10.1556","volume":"156","author":[{"given":"Alajos","family":"P\u00e1r","sequence":"first","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ron","family":"Vincze","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"P\u00e1r","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2015.30173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:59:11Z","timestamp":1550588351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2015.30173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":0,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1556\/650.2015.30173"],"URL":"https:\/\/doi.org\/10.1556\/650.2015.30173","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}