{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:42:42Z","timestamp":1761489762791},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Introduction: Myositis is an autoimmune disease characterised by proximal muscle weakness. Aim: The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies. Method: Antibodies were detected using immunoblot and immunoprecipitation. Results: Of the 330 patients with nyositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease. Conclusions: Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy. Orv. Hetil., 2015, 156(36), 1451\u20131459. <\/jats:p>","DOI":"10.1556\/650.2015.30221","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T10:12:29Z","timestamp":1441015949000},"page":"1451-1459","source":"Crossref","is-referenced-by-count":3,"title":["Dermatomyositis-specifikus autoantitesttel rendelkez\u0151                     \u00e9s autoantitest-negat\u00edv betegeink klinikai jellemz\u0151inek \u00e9s laborat\u00f3riumi                     param\u00e9tereinek \u00f6sszehasonl\u00edt\u00e1sa"],"prefix":"10.1556","volume":"156","author":[{"given":"Levente","family":"Bodoki","sequence":"first","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. k\u00f6r\u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Budai","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. k\u00f6r\u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Nagy-Vincze","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. k\u00f6r\u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Griger","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. k\u00f6r\u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Betteridge","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology,                         University of Bath Bath, Egyes\u00fclt Kir\u00e1lys\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Dank\u00f3","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. k\u00f6r\u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2015.30221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:08:49Z","timestamp":1550606929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2015.30221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":0,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1556\/650.2015.30221"],"URL":"https:\/\/doi.org\/10.1556\/650.2015.30221","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}