{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:13:26Z","timestamp":1777648406320,"version":"3.51.4"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"47","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p> The reperfusion of acute ischaemic myocardium is essential for myocardial salvage, so called \u201cgold standard\u201d therapy, however it can results serious damage in the myocardium. Functional alterations occur, including depressed contractile function and decreased coronary flow as well as altered vascular reactivity. Over the several decades it has been demonstrated that oxygen radical formation is greatly increased in post-ischaemic heart and serves as a critical central mechanism of ischaemic-reperfusion injury. However it has been demonstrated that free radical play an important role in the endogenous adaptation phenomenon of the heart, too. Ischaemic preconditioning is a cellular adaptive response of the heart to stress, which provides the most potent endogenous protection against reperfusion arrhytmias, stunning and infarction. Postconditioning defined as brief periods of ischaemia and reperfusion during the very early minutes of reperfusion stimulates endogenous adaptation. Postconditioning may also attenuate the damage to endothelial cells and cardiomyocytes from oxidants, cytokines, proteases and inflammatory cells. Orv. Hetil., 2015, 156(47), 1908\u20131911. <\/jats:p>","DOI":"10.1556\/650.2015.30304","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T08:13:51Z","timestamp":1447488831000},"page":"1908-1911","source":"Crossref","is-referenced-by-count":1,"title":["A szabad gy\u00f6k\u00f6s reakci\u00f3k jelent\u0151s\u00e9ge a sz\u00edvizom                     ischaemi\u00e1s-reperf\u00fazi\u00f3s k\u00e1rosod\u00e1s\u00e1ban \u00e9s az endog\u00e9n adapt\u00e1ci\u00f3                     induk\u00e1l\u00e1s\u00e1ban"],"prefix":"10.1556","volume":"156","author":[{"given":"Erzs\u00e9bet","family":"R\u0151th","sequence":"first","affiliation":[{"name":"Szent\u00e1gothai J\u00e1nos Kutat\u00f3k\u00f6zpont, P\u00e9csi Tudom\u00e1nyegyetem P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 20., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2015.30304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:02:16Z","timestamp":1550606536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2015.30304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":0,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1556\/650.2015.30304"],"URL":"https:\/\/doi.org\/10.1556\/650.2015.30304","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}