{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T13:57:33Z","timestamp":1721224653632},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"51","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> The technical developments leading to revolution in clinical genetic testing offer new approaches for patients with cancer. From one mutation or one gene approach the scale of genetic testing moved to whole exome or whole genome scale. It is well known that many tumours are genetically determined ans they are part of familial tumour syndromes. In addition, some mutations indicate specific molecular targeted therapies. Although sampling and sample preparation are different for testing germline and somatic mutations, the technical background of the analysis is the same. The aim of clinical genetic testing is to identify patients who are carriers of disease-causing mutations or to test tumour tissue for the presence of genetic alterations which may be targets for therapeutic approaches. In this review the authors summarize novel possibilities offered by next-generation sequencing in clinical genetic testing of patients with endocrine tumours. In addition, the authors review recent guidelines on technical and ethical issues related to these novel methods. Orv. Hetil., 2015, 156(51), 2063\u20132069. <\/jats:p>","DOI":"10.1556\/650.2015.30316","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T08:31:24Z","timestamp":1449909084000},"page":"2063-2069","source":"Crossref","is-referenced-by-count":1,"title":["\u00daj m\u00f3dszertani lehet\u0151s\u00e9gek \u00e9s ezek alkalmaz\u00e1sa a                     hormon\u00e1lis rendszer daganatainak genetikai kivizsg\u00e1l\u00e1s\u00e1ban"],"prefix":"10.1556","volume":"156","author":[{"given":"Attila","family":"Pat\u00f3cs","sequence":"first","affiliation":[{"name":"\u201eLend\u00fclet\u201d \u00d6r\u00f6kletes Endokrin Daganatok Kutat\u00f3csoport,                         Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"},{"name":"Bionikai Innov\u00e1ci\u00f3s K\u00f6zpont Nonprofit Kft. Budapest"},{"name":"Laborat\u00f3riumi Medicina Int\u00e9zet, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, Szentkir\u00e1lyi u. 46., 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Lik\u00f3","sequence":"additional","affiliation":[{"name":"\u201eLend\u00fclet\u201d \u00d6r\u00f6kletes Endokrin Daganatok Kutat\u00f3csoport,                         Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriett","family":"Butz","sequence":"additional","affiliation":[{"name":"Molekul\u00e1ris Medicina Kutat\u00f3csoport, Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9lia","family":"Baghy","sequence":"additional","affiliation":[{"name":"Bionikai Innov\u00e1ci\u00f3s K\u00f6zpont Nonprofit Kft. Budapest"},{"name":"I. Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Bionikai Innov\u00e1ci\u00f3s K\u00f6zpont Nonprofit Kft. Budapest"},{"name":"Molekul\u00e1ris Medicina Kutat\u00f3csoport, Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2015.30316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:15:29Z","timestamp":1550607329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2015.30316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":0,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1556\/650.2015.30316"],"URL":"https:\/\/doi.org\/10.1556\/650.2015.30316","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}