{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:41:17Z","timestamp":1648561277761},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p> Introduction: In idiopathic inflammatory myopathies, the presence of anti-Jo-1 antibody defines a distinct clinical phenotype (myositis, arthritis, interstitial lung disease, Raynaud\u2019s phenomenon fever, mechanic\u2019s hands), called antisynthetase syndrome. Aim: To determine the demographic data as well as clinical, laboratory and terapeutical features of anti-Jo1 positive patients, followed by the department of the authors. Method: The medical records of 49 consecutive anti-Jo1 patients were reviewed. Results: Demographic and clinical results were very similar to those published by other centers. Significant correlation was found between the anti-Jo-1 titer and the creatine kinase and C-reactive protein levels. Distinct laboratory results measured at the time of diagnosis of the disease (C-reactive protein, antigen A associated with Sjogren\u2019s syndrome, positive rheumatoid factor), and the presence of certain clinical symptoms (fever, vasculitic skin) may indicate a worse prognosis within the antisyntetase positive patient group. Conclusion: In the cases above more agressive immunosuppressive therapy may be required. Orv. Hetil., 2016, 157(15), 575\u2013583. <\/jats:p>","DOI":"10.1556\/650.2016.30400","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T07:55:24Z","timestamp":1459583724000},"page":"575-583","source":"Crossref","is-referenced-by-count":1,"title":["Az anti-Jo-1-pozit\u00edv antiszintet\u00e1z szindr\u00f3ma                     jellegzetess\u00e9gei gondozott betegeink alapj\u00e1n"],"prefix":"10.1556","volume":"157","author":[{"given":"Katalin","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Nagy-Vincze","sequence":"additional","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Bodoki","sequence":"additional","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Hodosi","sequence":"additional","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Dank\u00f3","sequence":"additional","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Griger","sequence":"additional","affiliation":[{"name":"Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Klinikai K\u00f6zpont Debrecen, M\u00f3ricz Zs. \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2016.30400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:53:05Z","timestamp":1550605985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2016.30400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1556\/650.2016.30400"],"URL":"https:\/\/doi.org\/10.1556\/650.2016.30400","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}