{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:03:58Z","timestamp":1648753438118},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p> In type 1 diabetic patients perfect normoglycaemia can only be achieved by successful transplantation of the pancreas or Langerhans\u2019 islets. Surgical transplantation of the whole pancreas is an invasive operation exerting great burden on the patients. Transplantation of the islets of Langerhans does not burden the patients but the survival of the islet grafts is limited. Both interventions are hampered by the lack of donor organs. However, much of these difficulties could be overcome by the use of \u201cartificial \u03b2-cells\u201d which ought to have an ultrastructure identical with that of natural \u03b2-cells and produce and secrete insulin in a glucose dependent manner. At present three such methods are at our disposal: transformation of the ductal cells of the exocrine pancreas into \u03b2-cells, development of \u03b2-cells from stem-cells, and neogenesis of Langerhans\u2019 islets induced by viral delivery of transcription factors. The author summarises the experience and experimental results obtained with the use of the three methods. Orv. Hetil., 2016, 157(19), 740\u2013745. <\/jats:p>","DOI":"10.1556\/650.2016.30440","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T06:12:18Z","timestamp":1462169538000},"page":"740-745","source":"Crossref","is-referenced-by-count":0,"title":["\u0150ssejtter\u00e1pia, \u03b2-sejt- \u00e9s Langerhans-sziget-neogenezis:                     a j\u00f6v\u0151 lehets\u00e9ges ter\u00e1pi\u00e1i 1-es t\u00edpus\u00fa diabetesben?"],"prefix":"10.1556","volume":"157","author":[{"given":"L\u00e1szl\u00f3","family":"Ger\u0151","sequence":"first","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, Kor\u00e1nyi S. u. 2\/A, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2016.30440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:46:54Z","timestamp":1550605614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2016.30440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":0,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1556\/650.2016.30440"],"URL":"https:\/\/doi.org\/10.1556\/650.2016.30440","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}