{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:08:59Z","timestamp":1698682139112},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"37","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p> Chronic myelogenous leukemia is a clonal myeloproliferative neoplasm caused by reciprocal translocation involving chromosomes 9 and 22 resulting in the expression of a constitutively activated BCR-ABL1 tyrosine kinase that leads to the malignant transformation of the hematopoietic stem cells. The condition was previously known as a relentlessly progressive disease, but the treatment was revolutionalized by the efficacy of tyrosine kinase inhibitors. Therapeutic success is thus currently determined by the depth of molecular response achieved on therapy. Multiple tyrosine kinase agents are available even for the first line treatment. This guideline summarizes current focal points of the treatment of chronic myelogenous leukemia specific to Hungary and provides definitions for optimal molecular responses in this condition. Orv. Hetil., 2016, 157(37), 1459\u20131468. <\/jats:p>","DOI":"10.1556\/650.2016.30521","type":"journal-article","created":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T06:58:03Z","timestamp":1473577083000},"page":"1459-1468","source":"Crossref","is-referenced-by-count":3,"title":["A kr\u00f3nikus myeloid leukaemia korszer\u0171 diagnosztik\u00e1ja \u00e9s                     kezel\u00e9se"],"prefix":"10.1556","volume":"157","author":[{"given":"Judit","family":"Demeter","sequence":"first","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Poros","sequence":"additional","affiliation":[{"name":"Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"B\u00f6d\u00f6r","sequence":"additional","affiliation":[{"name":"I. Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"III. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Masszi","sequence":"additional","affiliation":[{"name":"III. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2016.30521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:26:55Z","timestamp":1550608015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2016.30521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":0,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1556\/650.2016.30521"],"URL":"https:\/\/doi.org\/10.1556\/650.2016.30521","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}