{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T14:15:20Z","timestamp":1648563320564},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p> Introduction: During 2011 and 2013, 155 Hungarian hepatitis C genotype 1 infected patients, mostly with advanced liver fibrosis, who did not respond to prior peginterferon + ribavirin dual therapy, started boceprevir based triple therapy in an early access program. Aim and method: Efficacy and safety of the therapy was retrospectively assessed based on sustained virologic responses, as well as on frequency and type of serious adverse events and of those leading to therapy discontinuation. Results: In an intent-to-treat analysis 39.4% patients (61\/155) reached sustained virologic response. Amongst pervious relapsers, partial responders and null-responders 59.5%, 41.4 % and 22.9% (p&lt;0.05 compared to the other two categories) reached sustained virologic response, respectively, while amongst non-cirrhotics and cirrhotics 52.5% and 31.3% (p&lt;0.05 compared to the non-cirrhotics) achieved sutained virologic response, respectively. Six out of the 33 most difficult to cure patients (previous null responder and cirrhotic) have reached sustained virologic response (18.2%). Frequency of early discontinuations due to insufficient virologic response was 31.1%, while due to adverse event 10.3%. Reported frequency of serious adverse event was 9.8%. These events represented anemia, diarrhoea, depression, agranulocytosis, elevated aminotransferases, generalized dermatitis and severe gingivitis with loss of teeth, prolonged QT interval on ECG, generalized oedema and severe dyspnoea, uroinfection, exacerbation of Crohn\u2019s disease, Campylobacter pylori infection and unacceptable weakness and fatigue. Eight patients received transfusion, 4 patients erythropoietin and 1 granulocyte colony stimulating factor during therapy. No death has been reported. Conclusions: With boceprevir based triple therapy, one of the bests available in 2011\u20132013 in Hungary, a relevant proportion of hepatitis C infected patients with advanced liver fibrosis achieved sustained viral response. In this cohort, side-effects resembled those reported in registration studies, and resulted in therapy discontinuation with consequent treatment failure in a relevant number of patients. Efficacy and tolerability of boceprevir-based triple therapy are suboptimal, particularly in the most difficult to cure patient population. Orv. Hetil., 2016, 157(34), 1366\u20131374. <\/jats:p>","DOI":"10.1556\/650.2016.30538","type":"journal-article","created":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T01:21:32Z","timestamp":1471742492000},"page":"1366-1374","source":"Crossref","is-referenced-by-count":1,"title":["Bocepreviralap\u00fa h\u00e1rmas kezel\u00e9s hat\u00e9konys\u00e1g\u00e1nak \u00e9s                     biztons\u00e1goss\u00e1g\u00e1nak retrospekt\u00edv elemz\u00e9se el\u0151rehaladott fibrosisst\u00e1dium\u00fa,                     hepatitis C-v\u00edrus 1-es genot\u00edpussal fert\u0151z\u00f6tt, kor\u00e1bban sikertelen\u00fcl kezelt                     magyar betegekn\u00e9l"],"prefix":"10.1556","volume":"157","author":[{"given":"B\u00e9la","family":"Hunyady","sequence":"first","affiliation":[{"name":"Gasztroenterol\u00f3gia Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r, Talli\u00e1n Gyula u. 20\u201332., 7400"},{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, Klinikai K\u00f6zpont P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"Abonyi","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Csefk\u00f3","sequence":"additional","affiliation":[{"name":"R\u00e9thy P\u00e1l K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet B\u00e9k\u00e9scsaba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Gervain","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szat \u00e9s Molekul\u00e1ris Diagnosztikai                     Laborat\u00f3rium, Fej\u00e9r Megyei Szent Gy\u00f6rgy Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z Sz\u00e9kesfeh\u00e9rv\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Haragh","sequence":"additional","affiliation":[{"name":"Gasztroenterol\u00f3gia Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r, Talli\u00e1n Gyula u. 20\u201332., 7400"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Hepatol\u00f3giai Szakrendel\u00e9s \u00e9s Budai Hepatol\u00f3giai Centrum,                         Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zak Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Jancsik","sequence":"additional","affiliation":[{"name":"Ken\u00e9zy Gyula K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Eg\u00e9szs\u00e9g\u00fcgyi Szolg\u00e1ltat\u00f3 Kft. 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Belgy\u00f3gy\u00e1szat, F\u0151v\u00e1rosi \u00d6nkorm\u00e1nyzat Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2016.30538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T15:20:27Z","timestamp":1550589627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2016.30538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":0,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1556\/650.2016.30538"],"URL":"https:\/\/doi.org\/10.1556\/650.2016.30538","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}