{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:10:09Z","timestamp":1698768609085},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"52","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Stroke is the third most common cause of death worldwide following myocardial infaction and malignancies, furthermore, its functional outcome is the worst of all conditions. Cholesterol, especially LDL-cholesterol plays a key role in the formation of atherosclerotic plaques. It has been verified recently that escalating incidence and mortality of cerebrovascular diseases are proportional to increased levels of LDL-cholesterol. Statin therapy undeniably reduces the risk of stroke, however other methods for decreasing lipid levels have not been proved significantly effective. Preventive effect of high-dose statin treatment is without doubt, although administration of such high dosage might require special precautions for patients with prior intracerebral hemorrhage and it also risks development of incident diabetes. The recently published IMPROVE-IT study is the first to prove that the addition of ezetimibe as a non-statin type drug, to statin treatment contributes to further reduction of LDL-cholesterol. The combination treatment results in additional decrease in the incidence and mortality of cerebrovascular events, without any expansion in the number or adverse effects. These results confirm the importance of any further reduction of LDL-cholesterol levels. Achieving target values with statin-ezetimibe combination allows administration of low to moderate dose of statin, which decreases risks of adverse effects related to high-dose statin therapy. Orv. Hetil., 2016, 157(52), 2059\u20132065. <\/jats:p>","DOI":"10.1556\/650.2016.30643","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T06:22:17Z","timestamp":1482646937000},"page":"2059-2065","source":"Crossref","is-referenced-by-count":3,"title":["Lipidek \u00e9s az agy\u00e9rbetegs\u00e9g \u2013 \u00daj lehet\u0151s\u00e9gek az                     LDL-koleszterin-szint cs\u00f6kkent\u00e9s\u00e9re"],"prefix":"10.1556","volume":"157","author":[{"given":"Emese","family":"Lovadi","sequence":"first","affiliation":[{"name":"Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Cs\u00e9csei","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csenge","family":"Lovig","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Kar\u00e1di","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Szap\u00e1ry","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2016.30643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:50:31Z","timestamp":1550605831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2016.30643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":0,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1556\/650.2016.30643"],"URL":"https:\/\/doi.org\/10.1556\/650.2016.30643","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}