{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T17:24:28Z","timestamp":1649006668691},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Placental vascular endothelial growth factor A (VEGF-A) gene and endoglin gene are both overexpressed in placental samples obtained from pregnancies with intrauterine growth restriction compared to normal pregnancies. In the background of these changes a mechanism can be supposed, in which the increased endoglin activity in intrauterine growth restriction (IUGR) leads to impaired placental circulation through an antioangiogenetic effect. This results in the development of placental vascular dysfunction and chronic fetal hypoxia. It is chronic hypoxia that turns on VEGF-A as a compensatory mechanism to improve fetal vascular blood supply by promoting placental blood vessel formation. Although the maternal serum placental growth factor (PlGF) level is a potential predictor for both IUGR and praeeclampsia, placental PlGF gene activity may be less of an active in the regulation of placental circulation in IUGR pregnancies during the later stages of gestation. Orv. Hetil., 2017, 158(16), 612\u2013617. <\/jats:p>","DOI":"10.1556\/650.2017.30622","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T04:34:45Z","timestamp":1492490085000},"page":"612-617","source":"Crossref","is-referenced-by-count":0,"title":["A legjelent\u0151sebb angiogeneticus g\u00e9nek m\u00e9hlep\u00e9nyi                     expresszi\u00f3j\u00e1nak v\u00e1ltoz\u00e1sai a m\u00e9hen bel\u00fcli n\u00f6veked\u00e9si visszamarad\u00e1s                     h\u00e1tter\u00e9ben"],"prefix":"10.1556","volume":"158","author":[{"given":"P\u00e9ter","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Clinical Research Unit Hungary Sziksz\u00f3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Rab","sequence":"additional","affiliation":[{"name":"Landeskrankenhaus Feldkirch Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Szentp\u00e9teri","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Gyn\u00e4kologie und Geburtshilfe und allgemeine Medizin Wehingen, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef G\u00e1bor","family":"Jo\u00f3","sequence":"additional","affiliation":[{"name":"I. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, Baross u. 27., 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Kornya","sequence":"additional","affiliation":[{"name":"Sz\u00fcl\u00e9szet-N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly, Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:57:06Z","timestamp":1550588226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1556\/650.2017.30622"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30622","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}