{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T23:38:34Z","timestamp":1648510714918},"reference-count":1,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: In order to establish and use a national registry, several Hungarian hematology centers collected data of myeloproliferative neoplasia patients. Aim: The recent publication is an analysis of the data of registered essential thrombocythaemic patients. Method: an online electronic registry has been established, using 2008 World Health Organization\u2019s diagnostic criteria and thrombotic risk was evaluated according to Landolfi stratification. Results: Data of 350 essential thrombocythaemic patients from 15 Hungarian hematology centers entered up to the date of June 30, 2015 were used for analysis. Patients were followed up to (median) 6 years. The epidemiologic data (age, gender) and thrombotic events prior and after the diagnosis, were similar to the literature. The thrombotic events of anagrelide treated patient (n = 139) and the hydroxyurea + aspirin treated patients (n = 141) have been compared. The major arterial and venous events were similar between the groups, but there were fivefold less minor arterial and venous events in the anagrelide group (p&lt;0.001). Thrombotic incidence after diagnosis were influenced only by medication and thrombotic events before the diagnosis. Conclusions: Anagrelide significantly decreased the number of patients experiencing minor arterial and minor venous thrombosis, vs hydroxyurea + aspirin. Despite of the treatment the risk of thrombotic events after diagnosis remained high, and was significantly increased in patients with thrombosis before diagnosis. Orv. Hetil., 2017, 158(3), 111\u2013116. <\/jats:p>","DOI":"10.1556\/650.2017.30638","type":"journal-article","created":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T09:38:43Z","timestamp":1485077923000},"page":"111-116","source":"Crossref","is-referenced-by-count":0,"title":["Philadelphia-negat\u00edv kr\u00f3nikus Myeloproliferativ                     Neoplasia Magyarorsz\u00e1gi Regiszter. <i>Essentialis thrombocythaemi\u00e1s                         betegeink adatainak elemz\u00e9se<\/i>"],"prefix":"10.1556","volume":"158","author":[{"given":"P\u00e9ter","family":"Dombi","sequence":"first","affiliation":[{"name":"Szent Borb\u00e1la K\u00f3rh\u00e1z Tatab\u00e1nya, D\u00f3zsa Gy. \u00fat 77., 2800"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Ill\u00e9s","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Demeter","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Homor","sequence":"additional","affiliation":[{"name":"B\u00f6lcs\u00e9szet- \u00e9s T\u00e1rsadalomtudom\u00e1nyi Kar,                         P\u00e1zm\u00e1ny P\u00e9ter Katolikus Egyetem Piliscsaba (Esztergom)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Simon","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Udvardy","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Kar\u00e1di","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m","family":"Kellner","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Egyed","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12806"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:56:16Z","timestamp":1550606176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":1,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1556\/650.2017.30638"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30638","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}