{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:52:17Z","timestamp":1789573937764,"version":"build-2803163510"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction and aim: Former studies suggest the frequent coexistence of Hashimoto\u2019s thyreoditis with papillary thyroid cancer, frequently featured by multifocal carcinogenesis but lower clinical stages compared to thyroid cancers lacking thyroiditis. We examined the clinico-pathological correlations between Hashimoto\u2019s thyroditis and papillary thyroid cancer in our region in the North-Eastern part of Hungary. Patients and method: We included a total of 230 patients with papillary thyroid cancer who underwent thyroid surgery at the Surgical Department of the University of Debrecen. Patients\u2019 sex, age, multifocality of thyroid cancer and clinical stage were evaluated. Results: Cases included 40 patients (17.4%) with (4 male, 36 female) and 190 (82.6%) patients without HT (44 male, 146 female). Hashimoto\u2019s thyroiditis related thyroid cancer was almost exclusively associated with the papillary histological type. Multifocality of papillary cancer was significantly more frequent with coexisting Hashimoto\u2019s thyroiditis (16\/40; 40.0%) compared to cases uninvolved (45\/190; 23.7%; p = 0.034). In contrast, lymph node metastasis was significantly less frequent among patients with Hashimoto\u2019s thyroiditis (4 pN1 [36.4%]; 7 pN0 [63.6%]) then without it (34 pN1 [82.9%]; 7 pN0 [17.1%]; p = 0.002). Conclusion: Higher frequency and multifocality of papillary thyroid cancer might be the consequence of preexisting Hashimoto\u2019s thyroiditis to be considered as a preneoplastic stimulus supporting carcinogenesis, though the exact pathomechanism of this correlation is not clear yet. Orv. Hetil., 2017, 158(5), 178\u2013182. <\/jats:p>","DOI":"10.1556\/650.2017.30647","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T09:33:14Z","timestamp":1485768794000},"page":"178-182","source":"Crossref","is-referenced-by-count":7,"title":["A Hashimoto-thyreoiditisben kialakul\u00f3 papillaris                     pajzsmirigy-carcinoma klinikopatol\u00f3giai jellegzetess\u00e9gei"],"prefix":"10.1556","volume":"158","author":[{"given":"Sarolta","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Gy\u0151ry","sequence":"additional","affiliation":[{"name":"Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Nagy","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:46:18Z","timestamp":1550605578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1556\/650.2017.30647"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30647","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}