{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T10:00:16Z","timestamp":1648634416542},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> At present, the direct thrombin inhibitor dabigatran is the only one amongst the new direct anticoagulants which has an effective, specific reversal agent. The novel agent idarucizumab is a humanized, monoclonal antibody fragment binds to dabigatran within minutes thereby offers an opportunity to induce a safe, long-lasting reverse of the anticoagulant effects of dabigatran. The authors describe the first use of idarucizumab in Hungary (23. 05. 2016) in an old female patient with non-valvular paroxysmal atrial fibrillation of high stroke risk-score and renal dysfunction who was taking dabigatran (2 x 110 mg\/day) when an acute abdomen developed requiring emergency cholecystectomy. Patient received the antidote (idarucizumab 2 x 2.5 g\/50 ml iv.) two hours before the surgical intervention, and she did not have any uncontrollable, life-threatening bleeding during the surgery. The high activated partial thromboplastin time relating to anticoagulative influence before the surgery normalized completely after administration of the antidote. Antagonizing dabigatran with idarucizumab was feasible and safe without any side effects. The patient received dabigatran therapy again after her recovery. Orv. Hetil., 2017, 158(10), 387\u2013392. <\/jats:p>","DOI":"10.1556\/650.2017.30684","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T04:46:28Z","timestamp":1488948388000},"page":"387-392","source":"Crossref","is-referenced-by-count":1,"title":["A dabigatran-antid\u00f3tum, az intrav\u00e9n\u00e1s idarucizumab els\u0151                     hazai alkalmaz\u00e1sa"],"prefix":"10.1556","volume":"158","author":[{"given":"Lajos","family":"Driesz","sequence":"first","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Barab\u00e1s","sequence":"additional","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Bod\u00f3cs","sequence":"additional","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Sz\u00e1nt\u00f3","sequence":"additional","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Herr","sequence":"additional","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Bencsik","sequence":"additional","affiliation":[{"name":"J\u00e1sz-Nagykun-Szolnok Megyei Het\u00e9nyi G\u00e9za K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Szolnok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim RCV GmbH &amp; Co KG Magyarorsz\u00e1gi Fi\u00f3ktelepe Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Borbola","sequence":"additional","affiliation":[{"name":"Gottsegen Gy\u00f6rgy Orsz\u00e1gos Kardiol\u00f3giai Int\u00e9zet Budapest, Pf. 88, 1450"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:48:34Z","timestamp":1550605714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1556\/650.2017.30684"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30684","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}