{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T09:07:44Z","timestamp":1723194464580},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"Supplement 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p> Treatment of hepatitis C is based on a national consensus guideline updated six-monthly according to local availability and affordability of approved therapies through a transparent allocation system in Hungary. This updated guideline incorporates some special new aspects, including recommendations for screening, diagnostics, use and allocation of novel direct acting antiviral agents. Indication of therapy in patients with no contraindication is based on demonstration of viral replication with consequent inflammation and\/or fibrosis in the liver. Non-invasive methods (elastographies and biochemical methods) are preferred for liver fibrosis staging. The budget allocated for these patients is limited. Therefore, expensive novel direct acting antiviral combinations as first line treatment are reimbursed only, if the freely available, but less effective and more toxic pegylated interferon plus ribavirin dual therapy deemed to prone high chance of adverse events and\/or low chance of cure. Priority is given to those with urgent need based on a pre-defined scoring system reflecting mainly the stage of the liver disease, but considering also additional factors, i.e., hepatic decompensation, other complications, activity and progression of liver disease, risk of transmission and other special issues. Approved treatments are restricted to the most cost-effective combinations based on the cost per sustained virological response value in different patient categories with consensus amongst treating physicians, the National Health Insurance Fund and patient\u2019s organizations. Interferon-free treatments and shorter therapy durations are preferred. Orv. Hetil., 2017, 158(Suppl. 1), 3\u201322. <\/jats:p>","DOI":"10.1556\/650.2017.30688","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T09:20:43Z","timestamp":1487668843000},"page":"3-22","source":"Crossref","is-referenced-by-count":3,"title":["A hepatitis C-v\u00edrus-fert\u0151z\u00e9s sz\u0171r\u00e9se, diagnosztik\u00e1ja,                     antivir\u00e1lis ter\u00e1pi\u00e1ja, kezel\u00e9s ut\u00e1ni gondoz\u00e1sa. <i>Magyar                         konszenzusaj\u00e1nl\u00e1s. \u00c9rv\u00e9nyes: 2016. okt\u00f3ber 15-t\u0151l<\/i>"],"prefix":"10.1556","volume":"158","author":[{"given":"B\u00e9la","family":"Hunyady","sequence":"first","affiliation":[{"name":"Gasztroenterol\u00f3gia Oszt\u00e1ly, Somogy Megyei Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z Kaposv\u00e1r, Talli\u00e1n Gy. u. 20\u201332., 7400"},{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Gerlei","sequence":"additional","affiliation":[{"name":"Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Gervain","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szat \u00e9s Molekul\u00e1ris Diagnosztikai                     Laborat\u00f3rium, Szent Gy\u00f6rgy Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z Sz\u00e9kesfeh\u00e9rv\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Hepatol\u00f3giai Szakrendel\u00e9s, Budapest \u00e9s Budai                     Hepatol\u00f3giai Centrum, Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zak Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Lengyel","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alajos","family":"P\u00e1r","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"P\u00e9ter","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"R\u00f3kusz","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Oszt\u00e1ly, MH Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont Honv\u00e9dk\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Schneider","sequence":"additional","affiliation":[{"name":"Infektol\u00f3gia Oszt\u00e1ly, Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Szalay","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Tornai","sequence":"additional","affiliation":[{"name":"Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, Belgy\u00f3gy\u00e1szati                     Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Werling","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Makara","sequence":"additional","affiliation":[{"name":"Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T05:32:19Z","timestamp":1578547939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":0,"journal-issue":{"issue":"Supplement 1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1556\/650.2017.30688"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30688","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}