{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T15:50:42Z","timestamp":1649087442024},"reference-count":1,"publisher":"Akademiai Kiado Zrt.","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of \u03b1-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson\u2019s disease (PD) and Parkinson\u2019s disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations. Due to the often atypical clinical presentation novel imaging techniques and biomarkers could help the early diagnosis. Although curative treatment is not available, therapies can improve quality of life. Clinicopathological studies are important in exploring pathomechanisms, ensuring accurate diagnosis and identifying therapeutic targets. Orv Hetil. 2017; 158(17): 643\u2013652. <\/jats:p>","DOI":"10.1556\/650.2017.30735","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T03:08:06Z","timestamp":1493003286000},"page":"643-652","source":"Crossref","is-referenced-by-count":1,"title":["A Lewy-testes demencia klinikai \u00e9s neuropatol\u00f3giai                     jellemz\u0151i"],"prefix":"10.1556","volume":"158","author":[{"given":"J\u00e1nos","family":"Bencze","sequence":"first","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Neuropatol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Simon","sequence":"additional","affiliation":[{"name":"Pszichi\u00e1triai \u00e9s Pszichoter\u00e1pi\u00e1s Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Bereczki","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society,                     Division of Neurogeriatrics, Karolinska Institute Stockholm, Sv\u00e9dorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Majer","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Neuropatol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"},{"name":"Pszichi\u00e1triai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9ta","family":"Varkoly","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Neuropatol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Murny\u00e1k","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Neuropatol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[{"name":"Pszichi\u00e1triai Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Neuropatol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"},{"name":"Institute of Psychiatry Psychology &amp; Neuroscience,                     Department of Old Age Psychiatry, King\u2019s College London London, Egyes\u00fclt Kir\u00e1lys\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0008-2"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:57:26Z","timestamp":1550588246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":1,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1556\/650.2017.30735"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30735","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}